DegronMD - Q9C0J1(B3GNT4)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A323V	TCGA-55-7573	LUAD	TCGA	IRRPLDPLD	DEG_APCC_DBOX_1	330:338	Mutation rewiring degron network	0.1389
p.R72C	TCGA-56-7223	LUSC	TCGA	PPTPRHS	DEG_SCF_FBW7_1	68:74	Mutation altering degron motif	0.719
p.R72C	SIDM01314	Colorectal Carcinoma	GDSC	PPTPRHS	DEG_SCF_FBW7_1	68:74	Mutation altering degron motif	0.719
p.S74N	TCGA-AA-3947	COAD	TCGA	PPTPRHS	DEG_SCF_FBW7_1	68:74	Mutation altering degron motif	0.7069
p.P69T	TCGA-AP-A0LT	UCEC	TCGA	PPTPRHS	DEG_SCF_FBW7_1	68:74	Mutation altering degron motif	0.5919
p.R72S	TCGA-BG-A0VZ	UCEC	TCGA	PPTPRHS	DEG_SCF_FBW7_1	68:74	Mutation altering degron motif	0.6316
p.R75Q	TCGA-CD-A4MI	STAD	TCGA	PPTPRHS	DEG_SCF_FBW7_1	68:74	Mutation rewiring degron network	0.3056
p.R72H	TCGA-EO-A22T	UCEC	TCGA	PPTPRHS	DEG_SCF_FBW7_1	68:74	Mutation altering degron motif	0.7133
p.V82M	TCGA-EY-A1GU	UCEC	TCGA	PPTPRHS	DEG_SCF_FBW7_1	68:74	Mutation rewiring degron network	0.1111
p.R67H	DO44055	BLCA	ICGC	PPTPRHS	DEG_SCF_FBW7_1	68:74	Mutation rewiring degron network	0.3056
p.R67H	DO41584	UCEC	ICGC	PPTPRHS	DEG_SCF_FBW7_1	68:74	Mutation rewiring degron network	0.3056
p.W335L	DO1071	BRCA	ICGC	IRRPLDPLD	DEG_APCC_DBOX_1	330:338	Mutation altering degron motif	0.7015
p.F71L	DO2995	BRCA	ICGC	PPTPRHS	DEG_SCF_FBW7_1	68:74	Mutation altering degron motif	0.6981
p.H324Y	DO5507	BRCA	ICGC	IRRPLDPLD	DEG_APCC_DBOX_1	330:338	Mutation rewiring degron network	0.1667
p.R325H	DO7776	COAD	ICGC	IRRPLDPLD	DEG_APCC_DBOX_1	330:338	Mutation rewiring degron network	0.1944
p.A60T	DO8463	COAD	ICGC	PPTPRHS	DEG_SCF_FBW7_1	68:74	Mutation rewiring degron network	0.1111
p.R78Q	DO10880	GBM	ICGC	PPTPRHS	DEG_SCF_FBW7_1	68:74	Mutation rewiring degron network	0.2222
p.R78Q	DO50078	UCEC	ICGC	PPTPRHS	DEG_SCF_FBW7_1	68:74	Mutation rewiring degron network	0.2222
p.R78Q	DO43907	UCEC	ICGC	PPTPRHS	DEG_SCF_FBW7_1	68:74	Mutation rewiring degron network	0.2222
p.A60S	DO229036	LICA	ICGC	PPTPRHS	DEG_SCF_FBW7_1	68:74	Mutation rewiring degron network	0.1111
p.S58T	DO229047	LICA	ICGC	PPTPRHS	DEG_SCF_FBW7_1	68:74	Mutation rewiring degron network	0.0556
p.S58T	DO230542	LUSC	ICGC	PPTPRHS	DEG_SCF_FBW7_1	68:74	Mutation rewiring degron network	0.0556
p.R325C	DO48682	LIRI	ICGC	IRRPLDPLD	DEG_APCC_DBOX_1	330:338	Mutation rewiring degron network	0.1944
p.L329I	DO37695	SKCM	ICGC	IRRPLDPLD	DEG_APCC_DBOX_1	330:338	Mutation rewiring degron network	0.3056
p.E330K	DO37567	SKCM	ICGC	IRRPLDPLD	DEG_APCC_DBOX_1	330:338	Mutation altering degron motif	0.7022
p.E330K	DO47459	SKCM	ICGC	IRRPLDPLD	DEG_APCC_DBOX_1	330:338	Mutation altering degron motif	0.7022
p.E330K	DO47777	STAD	ICGC	IRRPLDPLD	DEG_APCC_DBOX_1	330:338	Mutation altering degron motif	0.7022
p.L62V	DO50119	STAD	ICGC	PPTPRHS	DEG_SCF_FBW7_1	68:74	Mutation rewiring degron network	0.1667
p.R75H	DO51761	STAD	ICGC	PPTPRHS	DEG_SCF_FBW7_1	68:74	Mutation rewiring degron network	0.3056
p.R75H	DO41871	UCEC	ICGC	PPTPRHS	DEG_SCF_FBW7_1	68:74	Mutation rewiring degron network	0.3056
p.R69C	DO38683	STAD	ICGC	PPTPRHS	DEG_SCF_FBW7_1	68:74	Mutation altering degron motif	0.8301
p.R69C	ACH-001703	Lymphoma	CCLE	PPTPRHS	DEG_SCF_FBW7_1	68:74	Mutation altering degron motif	0.8301
p.R69C	VAL	haematopoietic and lymphoid tissue	COSMIC	PPTPRHS	DEG_SCF_FBW7_1	68:74	Mutation altering degron motif	0.8301
p.A336T	DO219773	UCEC	ICGC	IRRPLDPLD	DEG_APCC_DBOX_1	330:338	Mutation altering degron motif	0.7139
p.L62M	DO41518	UCEC	ICGC	PPTPRHS	DEG_SCF_FBW7_1	68:74	Mutation rewiring degron network	0.1667
p.R331Q	SIDM00535	Chondrosarcoma	GDSC	IRRPLDPLD	DEG_APCC_DBOX_1	330:338	Mutation altering degron motif	0.7329
p.R331Q	SIDM00493	Other Solid Cancers	GDSC	IRRPLDPLD	DEG_APCC_DBOX_1	330:338	Mutation altering degron motif	0.7329
p.A323S	SIDM00255	Neuroblastoma	GDSC	IRRPLDPLD	DEG_APCC_DBOX_1	330:338	Mutation rewiring degron network	0.1389
p.A323S	NB17	autonomic ganglia	COSMIC	IRRPLDPLD	DEG_APCC_DBOX_1	330:338	Mutation rewiring degron network	0.1389
p.F325L	SIDM00965	Small Cell Lung Carcinoma	GDSC	IRRPLDPLD	DEG_APCC_DBOX_1	330:338	Mutation rewiring degron network	0.1944
p.R332W	SIDM00881	Breast Carcinoma	GDSC	IRRPLDPLD	DEG_APCC_DBOX_1	330:338	Mutation altering degron motif	0.7523
p.R332W	HCC1428	breast	COSMIC	IRRPLDPLD	DEG_APCC_DBOX_1	330:338	Mutation altering degron motif	0.7523
p.L72F	ACH-000942	Leukemia	CCLE	PPTPRHS	DEG_SCF_FBW7_1	68:74	Mutation altering degron motif	0.6981
p.Y74C	ACH-000970	Colon/Colorectal Cancer	CCLE	PPTPRHS	DEG_SCF_FBW7_1	68:74	Mutation altering degron motif	0.7087
p.Y74C	SNU-C5	large intestine	COSMIC	PPTPRHS	DEG_SCF_FBW7_1	68:74	Mutation altering degron motif	0.7087
p.H324Q	ACH-001618	Leukemia	CCLE	IRRPLDPLD	DEG_APCC_DBOX_1	330:338	Mutation rewiring degron network	0.1667
p.C340R	CAL-62	thyroid	COSMIC	IRRPLDPLD	DEG_APCC_DBOX_1	330:338	Mutation rewiring degron network	0.2778

Kaplan plot for B3GNT4 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

B3GNT4

UniProt ID: Q9C0J1

Entrez ID: 79369

Protein name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 4 (EC 2.4.1.149) (UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 4) (BGnT-4) (Beta-1,3-Gn-T4) (Beta-1,3-N-acetylglucosaminyltransferase 4) (Beta3Gn-T4)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for B3GNT4 in