DegronMD

Uniprot ID: Q9C0J1

Source protein: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 4

Source gene: B3GNT4

Class: DEG_SCF_FBW7_1

Location: 68:74

E3 ligase: FBXW7

DEGRON score: 0.7358

ASA_SCORE: 98.6429

COIL: 0.963

CONS_SCORE: 0.4654

DSS_SCORE: 0.5352

HELIX: 0.0166

FCONS_SCORE: 0.9975

RIG_SCORE: 0.6072

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R72C	TCGA-56-7223	LUSC	TCGA	PPTPRHS	DEG_SCF_FBW7_1	0.719
p.R72C	SIDM01314	Colorectal Carcinoma	GDSC	PPTPRHS	DEG_SCF_FBW7_1	0.719
p.S74N	TCGA-AA-3947	COAD	TCGA	PPTPRHS	DEG_SCF_FBW7_1	0.7069
p.P69T	TCGA-AP-A0LT	UCEC	TCGA	PPTPRHS	DEG_SCF_FBW7_1	0.5919
p.R72S	TCGA-BG-A0VZ	UCEC	TCGA	PPTPRHS	DEG_SCF_FBW7_1	0.6316
p.R75Q	TCGA-CD-A4MI	STAD	TCGA	PPTPRHS	DEG_SCF_FBW7_1	0.3056
p.R72H	TCGA-EO-A22T	UCEC	TCGA	PPTPRHS	DEG_SCF_FBW7_1	0.7133
p.V82M	TCGA-EY-A1GU	UCEC	TCGA	PPTPRHS	DEG_SCF_FBW7_1	0.1111
p.R67H	DO44055	BLCA	ICGC	PPTPRHS	DEG_SCF_FBW7_1	0.3056
p.R67H	DO41584	UCEC	ICGC	PPTPRHS	DEG_SCF_FBW7_1	0.3056
p.F71L	DO2995	BRCA	ICGC	PPTPRHS	DEG_SCF_FBW7_1	0.6981
p.A60T	DO8463	COAD	ICGC	PPTPRHS	DEG_SCF_FBW7_1	0.1111
p.R78Q	DO10880	GBM	ICGC	PPTPRHS	DEG_SCF_FBW7_1	0.2222
p.R78Q	DO50078	UCEC	ICGC	PPTPRHS	DEG_SCF_FBW7_1	0.2222
p.R78Q	DO43907	UCEC	ICGC	PPTPRHS	DEG_SCF_FBW7_1	0.2222
p.A60S	DO229036	LICA	ICGC	PPTPRHS	DEG_SCF_FBW7_1	0.1111
p.S58T	DO229047	LICA	ICGC	PPTPRHS	DEG_SCF_FBW7_1	0.0556
p.S58T	DO230542	LUSC	ICGC	PPTPRHS	DEG_SCF_FBW7_1	0.0556
p.L62V	DO50119	STAD	ICGC	PPTPRHS	DEG_SCF_FBW7_1	0.1667
p.R75H	DO51761	STAD	ICGC	PPTPRHS	DEG_SCF_FBW7_1	0.3056
p.R75H	DO41871	UCEC	ICGC	PPTPRHS	DEG_SCF_FBW7_1	0.3056
p.R69C	DO38683	STAD	ICGC	PPTPRHS	DEG_SCF_FBW7_1	0.8301
p.R69C	ACH-001703	Lymphoma	CCLE	PPTPRHS	DEG_SCF_FBW7_1	0.8301
p.R69C	VAL	haematopoietic_and_lymphoid_tissue	COSMIC	PPTPRHS	DEG_SCF_FBW7_1	0.8301
p.L62M	DO41518	UCEC	ICGC	PPTPRHS	DEG_SCF_FBW7_1	0.1667
p.L72F	ACH-000942	Leukemia	CCLE	PPTPRHS	DEG_SCF_FBW7_1	0.6981
p.Y74C	ACH-000970	Colon/Colorectal Cancer	CCLE	PPTPRHS	DEG_SCF_FBW7_1	0.7087
p.Y74C	SNU-C5	large_intestine	COSMIC	PPTPRHS	DEG_SCF_FBW7_1	0.7087

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9C0J1	N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 4	DEG_SCF_FBW7_1	68:74	PPTPRHS	FBXW7	0.7358	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PPTPRHS

Degron related mutations and impact score

Drug responses associated with B3GNT4 mutations

All proteins holding degron of PPTPRHS