DegronMD

Uniprot ID: Q6UB99

Source protein: Ankyrin repeat domain-containing protein 11

Source gene: ANKRD11

Class: DEG_SCF_FBW7_2

Location: 1795:1802

E3 ligase: FBXW7

DEGRON score: 0.9979

ASA_SCORE: 109.4875

COIL: 0.751

CONS_SCORE: 0.4029

DSS_SCORE: 0.399

HELIX: 0.2315

FCONS_SCORE: 1.0354

RIG_SCORE: 0.7415

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R1797S	TCGA-66-2766	LUSC	TCGA	IRRTPEEE	DEG_SCF_FBW7_2	0.6316
p.R1797S	DO27747	LUSC	ICGC	IRRTPEEE	DEG_SCF_FBW7_2	0.6316
p.E1800K	TCGA-AP-A1E0	UCEC	TCGA	IRRTPEEE	DEG_SCF_FBW7_2	0.591
p.E1800K	DO43154	UCEC	ICGC	IRRTPEEE	DEG_SCF_FBW7_2	0.591
p.E1800K	SIDM00791	Chronic Myelogenous Leukemia	GDSC	IRRTPEEE	DEG_SCF_FBW7_2	0.591
p.E1800K	ACH-000551	Leukemia	CCLE	IRRTPEEE	DEG_SCF_FBW7_2	0.591
p.E1800K	ACH-002061	Leukemia	CCLE	IRRTPEEE	DEG_SCF_FBW7_2	0.591
p.E1800K	K-562	haematopoietic_and_lymphoid_tissue	COSMIC	IRRTPEEE	DEG_SCF_FBW7_2	0.591
p.D1794Y	TCGA-BA-A6DA	HNSC	TCGA	IRRTPEEE	DEG_SCF_FBW7_2	0.3056
p.D1794Y	DO44448	HNSC	ICGC	IRRTPEEE	DEG_SCF_FBW7_2	0.3056
p.S1790L	TCGA-E6-A1LX	UCEC	TCGA	IRRTPEEE	DEG_SCF_FBW7_2	0.6389
p.S1790L	DO34120	PACA	ICGC	IRRTPEEE	DEG_SCF_FBW7_2	0.6389
p.S1790L	DO41020	UCEC	ICGC	IRRTPEEE	DEG_SCF_FBW7_2	0.6389
p.P1799L	DO228253	MALY	ICGC	IRRTPEEE	DEG_SCF_FBW7_2	0.7582
p.F1803L	SIDM00328	Esophageal Squamous Cell Carcinoma	GDSC	IRRTPEEE	DEG_SCF_FBW7_2	0.3056
p.F1803L	ACH-000605	Esophageal Cancer	CCLE	IRRTPEEE	DEG_SCF_FBW7_2	0.3056
p.F1803L	TE-6	oesophagus	COSMIC	IRRTPEEE	DEG_SCF_FBW7_2	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6UB99	Ankyrin repeat domain-containing protein 11	DEG_SCF_FBW7_2	1795:1802	IRRTPEEE	FBXW7	0.9979	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons