DegronMD

Uniprot ID: Q8N157

Source protein: Jouberin

Source gene: AHI1

Class: DEG_APCC_DBOX_1

Location: 49:57

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5543

ASA_SCORE: 93.9

COIL: 0.5529

CONS_SCORE: 0.3077

DSS_SCORE: 0.5809

HELIX: 0.3861

FCONS_SCORE: 1.0033

RIG_SCORE: 0.7118

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T48I	TCGA-AX-A1CE	UCEC	TCGA	IRSNLHYMK	DEG_APCC_DBOX_1	0.3056
p.T48I	DO42280	UCEC	ICGC	IRSNLHYMK	DEG_APCC_DBOX_1	0.3056
p.K57R	TCGA-CN-4727	HNSC	TCGA	IRSNLHYMK	DEG_APCC_DBOX_1	0.6126
p.K57R	DO14258	HNSC	ICGC	IRSNLHYMK	DEG_APCC_DBOX_1	0.6126
p.S45L	TCGA-D6-6516	HNSC	TCGA	IRSNLHYMK	DEG_APCC_DBOX_1	0.6667
p.S45L	DO15623	HNSC	ICGC	IRSNLHYMK	DEG_APCC_DBOX_1	0.6667
p.L53I	TCGA-DU-6392	LGG	TCGA	IRSNLHYMK	DEG_APCC_DBOX_1	0.7174
p.L53I	DO22237	LGG	ICGC	IRSNLHYMK	DEG_APCC_DBOX_1	0.7174
p.M51I	DO233270	GACA	ICGC	IRSNLHYMK	DEG_APCC_DBOX_1	0.7618
p.V53I	DO10880	GBM	ICGC	IRSNLHYMK	DEG_APCC_DBOX_1	0.7076
p.V53I	DO228971	LICA	ICGC	IRSNLHYMK	DEG_APCC_DBOX_1	0.7076
p.Q47K	DO228976	LICA	ICGC	IRSNLHYMK	DEG_APCC_DBOX_1	0.2778
p.N46K	DO229037	LICA	ICGC	IRSNLHYMK	DEG_APCC_DBOX_1	0.25
p.E48D	DO50075	UCEC	ICGC	IRSNLHYMK	DEG_APCC_DBOX_1	0.3056
p.D65N	SIDM00683	Prostate Carcinoma	GDSC	IRSNLHYMK	DEG_APCC_DBOX_1	0.1111
p.D65N	SIDM01588	Endometrial Carcinoma	GDSC	IRSNLHYMK	DEG_APCC_DBOX_1	0.1111
p.D65N	ACH-000977	lymph_node	CCLE	IRSNLHYMK	DEG_APCC_DBOX_1	0.1111
p.D65N	ACH-000993	Endometrial/Uterine Cancer	CCLE	IRSNLHYMK	DEG_APCC_DBOX_1	0.1111
p.D65N	LNCaP-Clone-FGC	prostate	COSMIC	IRSNLHYMK	DEG_APCC_DBOX_1	0.1111
p.I67V	SIDM00720	Mesothelioma	GDSC	IRSNLHYMK	DEG_APCC_DBOX_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8N157	Jouberin	DEG_APCC_DBOX_1	49:57	IRSNLHYMK	APC,CDC20,FZR1	0.5543	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons