DegronMD - Q8N157(AHI1)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Data table is loading....

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E448V	TCGA-55-8514	LUAD	TCGA	VILFFE	LIG_APCC_ABBA_1	443:448	Mutation altering degron motif	0.7693
p.E448V	TCGA-55-8514	LUAD	TCGA	KVILFFE	LIG_APCC_ABBAyCdc20_2	442:448	Mutation altering degron motif	0.7693
p.E448V	DO23616	LUAD	ICGC	VILFFE	LIG_APCC_ABBA_1	443:448	Mutation altering degron motif	0.7693
p.E448V	DO23616	LUAD	ICGC	KVILFFE	LIG_APCC_ABBAyCdc20_2	442:448	Mutation altering degron motif	0.7693
p.E439K	TCGA-95-8494	LUAD	TCGA	VILFFE	LIG_APCC_ABBA_1	443:448	Mutation rewiring degron network	0.2222
p.E439K	TCGA-95-8494	LUAD	TCGA	KVILFFE	LIG_APCC_ABBAyCdc20_2	442:448	Mutation rewiring degron network	0.25
p.E439K	DO51198	LUAD	ICGC	VILFFE	LIG_APCC_ABBA_1	443:448	Mutation rewiring degron network	0.2222
p.E439K	DO51198	LUAD	ICGC	KVILFFE	LIG_APCC_ABBAyCdc20_2	442:448	Mutation rewiring degron network	0.25
p.T251A	TCGA-AA-3492	COAD	TCGA	AETST	DEG_SPOP_SBC_1	247:251	Mutation altering degron motif	0.7139
p.T251A	DO8224	COAD	ICGC	AETST	DEG_SPOP_SBC_1	247:251	Mutation altering degron motif	0.7139
p.T48I	TCGA-AX-A1CE	UCEC	TCGA	IRSNLHYMK	DEG_APCC_DBOX_1	49:57	Mutation rewiring degron network	0.3056
p.T48I	DO42280	UCEC	ICGC	IRSNLHYMK	DEG_APCC_DBOX_1	49:57	Mutation rewiring degron network	0.3056
p.K57R	TCGA-CN-4727	HNSC	TCGA	IRSNLHYMK	DEG_APCC_DBOX_1	49:57	Mutation altering degron motif	0.6126
p.K57R	DO14258	HNSC	ICGC	IRSNLHYMK	DEG_APCC_DBOX_1	49:57	Mutation altering degron motif	0.6126
p.F446L	TCGA-D1-A17Q	UCEC	TCGA	VILFFE	LIG_APCC_ABBA_1	443:448	Mutation altering degron motif	0.6981
p.F446L	TCGA-D1-A17Q	UCEC	TCGA	KVILFFE	LIG_APCC_ABBAyCdc20_2	442:448	Mutation altering degron motif	0.6981
p.F446L	DO41903	UCEC	ICGC	VILFFE	LIG_APCC_ABBA_1	443:448	Mutation altering degron motif	0.6981
p.F446L	DO41903	UCEC	ICGC	KVILFFE	LIG_APCC_ABBAyCdc20_2	442:448	Mutation altering degron motif	0.6981
p.S45L	TCGA-D6-6516	HNSC	TCGA	IRSNLHYMK	DEG_APCC_DBOX_1	49:57	Mutation blocking phosphorylation signal	0.6667
p.S45L	DO15623	HNSC	ICGC	IRSNLHYMK	DEG_APCC_DBOX_1	49:57	Mutation blocking phosphorylation signal	0.6667
p.L53I	TCGA-DU-6392	LGG	TCGA	IRSNLHYMK	DEG_APCC_DBOX_1	49:57	Mutation altering degron motif	0.7174
p.L53I	DO22237	LGG	ICGC	IRSNLHYMK	DEG_APCC_DBOX_1	49:57	Mutation altering degron motif	0.7174
p.Y432C	TCGA-EY-A1GV	UCEC	TCGA	KVILFFE	LIG_APCC_ABBAyCdc20_2	442:448	Mutation rewiring degron network	0.0556
p.Y432C	DO42785	UCEC	ICGC	KVILFFE	LIG_APCC_ABBAyCdc20_2	442:448	Mutation rewiring degron network	0.0556
p.L445M	TCGA-EY-A215	UCEC	TCGA	VILFFE	LIG_APCC_ABBA_1	443:448	Mutation altering degron motif	0.5999
p.L445M	TCGA-EY-A215	UCEC	TCGA	KVILFFE	LIG_APCC_ABBAyCdc20_2	442:448	Mutation altering degron motif	0.5999
p.L445M	DO42665	UCEC	ICGC	VILFFE	LIG_APCC_ABBA_1	443:448	Mutation altering degron motif	0.5999
p.L445M	DO42665	UCEC	ICGC	KVILFFE	LIG_APCC_ABBAyCdc20_2	442:448	Mutation altering degron motif	0.5999
p.S250I	TCGA-GN-A267	SKCM	TCGA	AETST	DEG_SPOP_SBC_1	247:251	Mutation altering degron motif	0.7341
p.S250I	DO38147	SKCM	ICGC	AETST	DEG_SPOP_SBC_1	247:251	Mutation altering degron motif	0.7341
p.E440G	DO228483	BRCA	ICGC	VILFFE	LIG_APCC_ABBA_1	443:448	Mutation rewiring degron network	0.25
p.E440G	DO228483	BRCA	ICGC	KVILFFE	LIG_APCC_ABBAyCdc20_2	442:448	Mutation rewiring degron network	0.2778
p.E440G	DO229005	COCA	ICGC	VILFFE	LIG_APCC_ABBA_1	443:448	Mutation rewiring degron network	0.25
p.E440G	DO229005	COCA	ICGC	KVILFFE	LIG_APCC_ABBAyCdc20_2	442:448	Mutation rewiring degron network	0.2778
p.K442E	DO222506	BTCA	ICGC	KVILFFE	LIG_APCC_ABBAyCdc20_2	442:448	Mutation altering degron motif	0.7022
p.I458V	DO234186	ESAD	ICGC	VILFFE	LIG_APCC_ABBA_1	443:448	Mutation rewiring degron network	0.0556
p.I458V	DO234186	ESAD	ICGC	KVILFFE	LIG_APCC_ABBAyCdc20_2	442:448	Mutation rewiring degron network	0.0556
p.M51I	DO233270	GACA	ICGC	IRSNLHYMK	DEG_APCC_DBOX_1	49:57	Mutation altering degron motif	0.7618
p.V53I	DO10880	GBM	ICGC	IRSNLHYMK	DEG_APCC_DBOX_1	49:57	Mutation altering degron motif	0.7076
p.V53I	DO228971	LICA	ICGC	IRSNLHYMK	DEG_APCC_DBOX_1	49:57	Mutation altering degron motif	0.7076
p.Q47K	DO228976	LICA	ICGC	IRSNLHYMK	DEG_APCC_DBOX_1	49:57	Mutation rewiring degron network	0.2778
p.N46K	DO229037	LICA	ICGC	IRSNLHYMK	DEG_APCC_DBOX_1	49:57	Mutation rewiring degron network	0.25
p.Q451L	DO52193	LIHC	ICGC	VILFFE	LIG_APCC_ABBA_1	443:448	Mutation rewiring degron network	0.25
p.Q451L	DO52193	LIHC	ICGC	KVILFFE	LIG_APCC_ABBAyCdc20_2	442:448	Mutation rewiring degron network	0.25
p.E48D	DO50075	UCEC	ICGC	IRSNLHYMK	DEG_APCC_DBOX_1	49:57	Mutation rewiring degron network	0.3056
p.T253A	SIDM01016	T-Lymphoblastic Leukemia	GDSC	AETST	DEG_SPOP_SBC_1	247:251	Mutation rewiring degron network	0.2778
p.T253A	ACH-000995	Leukemia	CCLE	AETST	DEG_SPOP_SBC_1	247:251	Mutation rewiring degron network	0.2778
p.T253A	Jurkat	haematopoietic and lymphoid tissue	COSMIC	AETST	DEG_SPOP_SBC_1	247:251	Mutation rewiring degron network	0.2778
p.D65N	SIDM00683	Prostate Carcinoma	GDSC	IRSNLHYMK	DEG_APCC_DBOX_1	49:57	Mutation rewiring degron network	0.1111
p.D65N	SIDM01588	Endometrial Carcinoma	GDSC	IRSNLHYMK	DEG_APCC_DBOX_1	49:57	Mutation rewiring degron network	0.1111
p.D65N	ACH-000977	lymph node	CCLE	IRSNLHYMK	DEG_APCC_DBOX_1	49:57	Mutation rewiring degron network	0.1111
p.D65N	ACH-000993	Endometrial/Uterine Cancer	CCLE	IRSNLHYMK	DEG_APCC_DBOX_1	49:57	Mutation rewiring degron network	0.1111
p.D65N	LNCaP-Clone-FGC	prostate	COSMIC	IRSNLHYMK	DEG_APCC_DBOX_1	49:57	Mutation rewiring degron network	0.1111
p.S437F	SIDM00907	Burkitt's Lymphoma	GDSC	VILFFE	LIG_APCC_ABBA_1	443:448	Mutation rewiring degron network	0.1667
p.S437F	SIDM00907	Burkitt's Lymphoma	GDSC	KVILFFE	LIG_APCC_ABBAyCdc20_2	442:448	Mutation rewiring degron network	0.1944
p.S437F	ACH-000440	Lymphoma	CCLE	VILFFE	LIG_APCC_ABBA_1	443:448	Mutation rewiring degron network	0.1667
p.S437F	ACH-000440	Lymphoma	CCLE	KVILFFE	LIG_APCC_ABBAyCdc20_2	442:448	Mutation rewiring degron network	0.1944
p.S437F	CA46	haematopoietic and lymphoid tissue	COSMIC	VILFFE	LIG_APCC_ABBA_1	443:448	Mutation rewiring degron network	0.1667
p.S437F	CA46	haematopoietic and lymphoid tissue	COSMIC	KVILFFE	LIG_APCC_ABBAyCdc20_2	442:448	Mutation rewiring degron network	0.1944
p.P242S	SIDM00863	Burkitt's Lymphoma	GDSC	AETST	DEG_SPOP_SBC_1	247:251	Mutation rewiring degron network	0.1944
p.P242S	SIDM00673	Breast Carcinoma	GDSC	AETST	DEG_SPOP_SBC_1	247:251	Mutation rewiring degron network	0.1944
p.P242S	SIDM00628	Breast Carcinoma	GDSC	AETST	DEG_SPOP_SBC_1	247:251	Mutation rewiring degron network	0.1944
p.I67V	SIDM00720	Mesothelioma	GDSC	IRSNLHYMK	DEG_APCC_DBOX_1	49:57	Mutation rewiring degron network	0.0556

Kaplan plot for AHI1 in

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

AHI1

UniProt ID: Q8N157

Entrez ID: 54806

Protein name: Jouberin (Abelson helper integration site 1 protein homolog) (AHI-1)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for AHI1 in