DegronMD

Uniprot ID: Q8N157

Source protein: Jouberin

Source gene: AHI1

Class: LIG_APCC_ABBAyCdc20_2

Location: 442:448

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6537

ASA_SCORE: 23.1

COIL: 0.191

CONS_SCORE: 0.4875

DSS_SCORE: 0.0335

HELIX: 0.0336

FCONS_SCORE: 1.3137

RIG_SCORE: 0.9528

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E448V	TCGA-55-8514	LUAD	TCGA	KVILFFE	LIG_APCC_ABBAyCdc20_2	0.7693
p.E448V	DO23616	LUAD	ICGC	KVILFFE	LIG_APCC_ABBAyCdc20_2	0.7693
p.E439K	TCGA-95-8494	LUAD	TCGA	KVILFFE	LIG_APCC_ABBAyCdc20_2	0.25
p.E439K	DO51198	LUAD	ICGC	KVILFFE	LIG_APCC_ABBAyCdc20_2	0.25
p.F446L	TCGA-D1-A17Q	UCEC	TCGA	KVILFFE	LIG_APCC_ABBAyCdc20_2	0.6981
p.F446L	DO41903	UCEC	ICGC	KVILFFE	LIG_APCC_ABBAyCdc20_2	0.6981
p.Y432C	TCGA-EY-A1GV	UCEC	TCGA	KVILFFE	LIG_APCC_ABBAyCdc20_2	0.0556
p.Y432C	DO42785	UCEC	ICGC	KVILFFE	LIG_APCC_ABBAyCdc20_2	0.0556
p.L445M	TCGA-EY-A215	UCEC	TCGA	KVILFFE	LIG_APCC_ABBAyCdc20_2	0.5999
p.L445M	DO42665	UCEC	ICGC	KVILFFE	LIG_APCC_ABBAyCdc20_2	0.5999
p.E440G	DO228483	BRCA	ICGC	KVILFFE	LIG_APCC_ABBAyCdc20_2	0.2778
p.E440G	DO229005	COCA	ICGC	KVILFFE	LIG_APCC_ABBAyCdc20_2	0.2778
p.K442E	DO222506	BTCA	ICGC	KVILFFE	LIG_APCC_ABBAyCdc20_2	0.7022
p.I458V	DO234186	ESAD	ICGC	KVILFFE	LIG_APCC_ABBAyCdc20_2	0.0556
p.Q451L	DO52193	LIHC	ICGC	KVILFFE	LIG_APCC_ABBAyCdc20_2	0.25
p.S437F	SIDM00907	Burkitt's Lymphoma	GDSC	KVILFFE	LIG_APCC_ABBAyCdc20_2	0.1944
p.S437F	ACH-000440	Lymphoma	CCLE	KVILFFE	LIG_APCC_ABBAyCdc20_2	0.1944
p.S437F	CA46	haematopoietic_and_lymphoid_tissue	COSMIC	KVILFFE	LIG_APCC_ABBAyCdc20_2	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8N157	Jouberin	LIG_APCC_ABBAyCdc20_2	442:448	KVILFFE	APC,CDC20,FZR1	0.6537	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons