DegronMD

Uniprot ID: Q8N157

Source protein: Jouberin

Source gene: AHI1

Class: LIG_APCC_ABBA_1

Location: 443:448

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6537

ASA_SCORE: 15.5667

COIL: 0.0973

CONS_SCORE: 0.5035

DSS_SCORE: 0.0354

HELIX: 0.0218

FCONS_SCORE: 1.3597

RIG_SCORE: 0.9692

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E448V	TCGA-55-8514	LUAD	TCGA	VILFFE	LIG_APCC_ABBA_1	0.7693
p.E448V	DO23616	LUAD	ICGC	VILFFE	LIG_APCC_ABBA_1	0.7693
p.F446L	TCGA-D1-A17Q	UCEC	TCGA	VILFFE	LIG_APCC_ABBA_1	0.6981
p.F446L	DO41903	UCEC	ICGC	VILFFE	LIG_APCC_ABBA_1	0.6981
p.L445M	TCGA-EY-A215	UCEC	TCGA	VILFFE	LIG_APCC_ABBA_1	0.5999
p.L445M	DO42665	UCEC	ICGC	VILFFE	LIG_APCC_ABBA_1	0.5999
p.E440G	DO228483	BRCA	ICGC	VILFFE	LIG_APCC_ABBA_1	0.25
p.E440G	DO229005	COCA	ICGC	VILFFE	LIG_APCC_ABBA_1	0.25
p.Q451L	DO52193	LIHC	ICGC	VILFFE	LIG_APCC_ABBA_1	0.25
p.E439K	TCGA-95-8494	LUAD	TCGA	VILFFE	LIG_APCC_ABBA_1	0.2222
p.E439K	DO51198	LUAD	ICGC	VILFFE	LIG_APCC_ABBA_1	0.2222
p.S437F	SIDM00907	Burkitt's Lymphoma	GDSC	VILFFE	LIG_APCC_ABBA_1	0.1667
p.S437F	ACH-000440	Lymphoma	CCLE	VILFFE	LIG_APCC_ABBA_1	0.1667
p.S437F	CA46	haematopoietic_and_lymphoid_tissue	COSMIC	VILFFE	LIG_APCC_ABBA_1	0.1667
p.I458V	DO234186	ESAD	ICGC	VILFFE	LIG_APCC_ABBA_1	0.0556

Showing 1 to 15 of 15 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8N157	Jouberin	LIG_APCC_ABBA_1	443:448	VILFFE	APC,CDC20,FZR1	0.6537	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons