DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
VILFFE
Uniprot ID:
Q8N157
Source protein:
Jouberin
Source gene:
AHI1
Class:
LIG_APCC_ABBA_1
Location:
443:448
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.6537
ASA_SCORE:
15.5667
COIL:
0.0973
CONS_SCORE:
0.5035
DSS_SCORE:
0.0354
HELIX:
0.0218
FCONS_SCORE:
1.3597
RIG_SCORE:
0.9692
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.E448V
TCGA-55-8514
LUAD
TCGA
VILFFE
LIG_APCC_ABBA_1
0.7693
p.E448V
DO23616
LUAD
ICGC
VILFFE
LIG_APCC_ABBA_1
0.7693
p.E439K
TCGA-95-8494
LUAD
TCGA
VILFFE
LIG_APCC_ABBA_1
0.2222
p.E439K
DO51198
LUAD
ICGC
VILFFE
LIG_APCC_ABBA_1
0.2222
p.F446L
TCGA-D1-A17Q
UCEC
TCGA
VILFFE
LIG_APCC_ABBA_1
0.6981
p.F446L
DO41903
UCEC
ICGC
VILFFE
LIG_APCC_ABBA_1
0.6981
p.L445M
TCGA-EY-A215
UCEC
TCGA
VILFFE
LIG_APCC_ABBA_1
0.5999
p.L445M
DO42665
UCEC
ICGC
VILFFE
LIG_APCC_ABBA_1
0.5999
p.E440G
DO228483
BRCA
ICGC
VILFFE
LIG_APCC_ABBA_1
0.25
p.E440G
DO229005
COCA
ICGC
VILFFE
LIG_APCC_ABBA_1
0.25
p.I458V
DO234186
ESAD
ICGC
VILFFE
LIG_APCC_ABBA_1
0.0556
p.Q451L
DO52193
LIHC
ICGC
VILFFE
LIG_APCC_ABBA_1
0.25
p.S437F
SIDM00907
Burkitt's Lymphoma
GDSC
VILFFE
LIG_APCC_ABBA_1
0.1667
p.S437F
ACH-000440
Lymphoma
CCLE
VILFFE
LIG_APCC_ABBA_1
0.1667
p.S437F
CA46
haematopoietic_and_lymphoid_tissue
COSMIC
VILFFE
LIG_APCC_ABBA_1
0.1667
Drug responses associated with AHI1 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of VILFFE
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q8N157
Jouberin
LIG_APCC_ABBA_1
443:448
VILFFE
APC,CDC20,FZR1
0.6537
More...