DegronMD

Uniprot ID: Q8N157

Source protein: Jouberin

Source gene: AHI1

Class: DEG_SPOP_SBC_1

Location: 247:251

E3 ligase: SPOP

DEGRON score: 0.7259

ASA_SCORE: 89.4

COIL: 0.9036

CONS_SCORE: 0.3647

DSS_SCORE: 0.4458

HELIX: 0.0428

FCONS_SCORE: 1.0138

RIG_SCORE: 0.7336

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T251A	TCGA-AA-3492	COAD	TCGA	AETST	DEG_SPOP_SBC_1	0.7139
p.T251A	DO8224	COAD	ICGC	AETST	DEG_SPOP_SBC_1	0.7139
p.S250I	TCGA-GN-A267	SKCM	TCGA	AETST	DEG_SPOP_SBC_1	0.7341
p.S250I	DO38147	SKCM	ICGC	AETST	DEG_SPOP_SBC_1	0.7341
p.T253A	SIDM01016	T-Lymphoblastic Leukemia	GDSC	AETST	DEG_SPOP_SBC_1	0.2778
p.T253A	ACH-000995	Leukemia	CCLE	AETST	DEG_SPOP_SBC_1	0.2778
p.T253A	Jurkat	haematopoietic_and_lymphoid_tissue	COSMIC	AETST	DEG_SPOP_SBC_1	0.2778
p.P242S	SIDM00863	Burkitt's Lymphoma	GDSC	AETST	DEG_SPOP_SBC_1	0.1944
p.P242S	SIDM00673	Breast Carcinoma	GDSC	AETST	DEG_SPOP_SBC_1	0.1944
p.P242S	SIDM00628	Breast Carcinoma	GDSC	AETST	DEG_SPOP_SBC_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8N157	Jouberin	DEG_SPOP_SBC_1	247:251	AETST	SPOP	0.7259	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	1658:1662	AETST	SPOP	0.7962	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	10547:10551	AETST	SPOP	0.8453	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	11582:11586	AETST	SPOP	0.734	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	11808:11812	AETST	SPOP	0.8397	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	11884:11888	AETST	SPOP	0.9518	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	1758:1762	AETST	SPOP	0.8715	More...
Q9P0J7	E3 ubiquitin-protein ligase KCMF1	DEG_SPOP_SBC_1	102:106	AETST	SPOP	0.5697	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons