DegronMD

Uniprot ID: Q8WXI7

Source protein: Mucin-16

Source gene: MUC16

Class: DEG_SPOP_SBC_1

Location: 1658:1662

E3 ligase: SPOP

DEGRON score: 0.7962

ASA_SCORE: 94.58

COIL: 0.823

CONS_SCORE: 0

DSS_SCORE: 0.6159

HELIX: 0.0358

FCONS_SCORE: 0

RIG_SCORE: 0.7066

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S1671Y	TCGA-43-2581	LUSC	TCGA	AETST	DEG_SPOP_SBC_1	0.0833
p.S1671Y	TCGA-B5-A1MR	UCEC	TCGA	AETST	DEG_SPOP_SBC_1	0.0833
p.S1671Y	DO26602	LUSC	ICGC	AETST	DEG_SPOP_SBC_1	0.0833
p.S1671Y	DO41758	UCEC	ICGC	AETST	DEG_SPOP_SBC_1	0.0833
p.E1659K	TCGA-4Z-AA80	BLCA	TCGA	AETST	DEG_SPOP_SBC_1	0.591
p.E1659K	DO218986	BLCA	ICGC	AETST	DEG_SPOP_SBC_1	0.591
p.M1664V	TCGA-B5-A3FC	UCEC	TCGA	AETST	DEG_SPOP_SBC_1	0.2778
p.M1664V	DO41871	UCEC	ICGC	AETST	DEG_SPOP_SBC_1	0.2778
p.A1648T	TCGA-BF-AAOU	SKCM	TCGA	AETST	DEG_SPOP_SBC_1	0.0556
p.A1648T	DO219460	SKCM	ICGC	AETST	DEG_SPOP_SBC_1	0.0556
p.A1648T	SIDM01608	Endometrial Carcinoma	GDSC	AETST	DEG_SPOP_SBC_1	0.0556
p.A1648T	ACH-000990	Endometrial/Uterine Cancer	CCLE	AETST	DEG_SPOP_SBC_1	0.0556
p.R1668K	TCGA-D3-A2JA	SKCM	TCGA	AETST	DEG_SPOP_SBC_1	0.1667
p.R1668K	DO47652	SKCM	ICGC	AETST	DEG_SPOP_SBC_1	0.1667
p.S1655F	TCGA-DA-A1HY	SKCM	TCGA	AETST	DEG_SPOP_SBC_1	0.25
p.S1655F	DO37409	SKCM	ICGC	AETST	DEG_SPOP_SBC_1	0.25
p.G1653E	TCGA-DK-A6AW	BLCA	TCGA	AETST	DEG_SPOP_SBC_1	0.1944
p.G1653E	TCGA-RP-A693	SKCM	TCGA	AETST	DEG_SPOP_SBC_1	0.1944
p.G1653E	DO48566	BLCA	ICGC	AETST	DEG_SPOP_SBC_1	0.1944
p.G1653E	DO220872	MELA	ICGC	AETST	DEG_SPOP_SBC_1	0.1944
p.G1653E	DO51268	SKCM	ICGC	AETST	DEG_SPOP_SBC_1	0.1944
p.E1667K	TCGA-EE-A2GH	SKCM	TCGA	AETST	DEG_SPOP_SBC_1	0.1944
p.E1667K	DO37643	SKCM	ICGC	AETST	DEG_SPOP_SBC_1	0.1944
p.A1665T	DO233239	GACA	ICGC	AETST	DEG_SPOP_SBC_1	0.25
p.A1658S	DO233273	GACA	ICGC	AETST	DEG_SPOP_SBC_1	0.7588
p.H1649N	DO229008	LICA	ICGC	AETST	DEG_SPOP_SBC_1	0.0833
p.S1656P	DO229479	SKCA	ICGC	AETST	DEG_SPOP_SBC_1	0.2778
p.P1651H	SIDM01197	Colorectal Carcinoma	GDSC	AETST	DEG_SPOP_SBC_1	0.1389
p.P1651H	ACH-000722	Colon/Colorectal Cancer	CCLE	AETST	DEG_SPOP_SBC_1	0.1389
p.P1651H	SNU-C1	large_intestine	COSMIC	AETST	DEG_SPOP_SBC_1	0.1389
p.A1648S	SIDM01140	Ovarian Carcinoma	GDSC	AETST	DEG_SPOP_SBC_1	0.0556
p.A1648S	ACH-001374	Ovarian Cancer	CCLE	AETST	DEG_SPOP_SBC_1	0.0556
p.A1648S	PA-1	ovary	COSMIC	AETST	DEG_SPOP_SBC_1	0.0556
p.T1672R	SIDM01491	Colorectal Carcinoma	GDSC	AETST	DEG_SPOP_SBC_1	0.0556
p.T1672R	ACH-000342	Colon/Colorectal Cancer	CCLE	AETST	DEG_SPOP_SBC_1	0.0556

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: AETST

Degron related mutations and impact score

Drug responses associated with MUC16 mutations

All proteins holding degron of AETST

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8N157	Jouberin	DEG_SPOP_SBC_1	247:251	AETST	SPOP	0.7259	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	1658:1662	AETST	SPOP	0.7962	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	10547:10551	AETST	SPOP	0.8453	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	11582:11586	AETST	SPOP	0.734	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	11808:11812	AETST	SPOP	0.8397	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	11884:11888	AETST	SPOP	0.9518	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	1758:1762	AETST	SPOP	0.8715	More...
Q9P0J7	E3 ubiquitin-protein ligase KCMF1	DEG_SPOP_SBC_1	102:106	AETST	SPOP	0.5697	More...