DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
AETST
Uniprot ID:
Q9P0J7
Source protein:
E3 ubiquitin-protein ligase KCMF1
Source gene:
KCMF1
Class:
DEG_SPOP_SBC_1
Location:
102:106
E3 ligase:
SPOP
DEGRON score:
0.5697
ASA_SCORE:
81.9
COIL:
0.856
CONS_SCORE:
0.6465
DSS_SCORE:
0.3079
HELIX:
0.0902
FCONS_SCORE:
0.9548
RIG_SCORE:
0.7684
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.S99C
TCGA-G2-A2EO
BLCA
TCGA
AETST
DEG_SPOP_SBC_1
0.25
p.S99C
DO456
BLCA
ICGC
AETST
DEG_SPOP_SBC_1
0.25
Drug responses associated with KCMF1 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of AETST
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q8N157
Jouberin
DEG_SPOP_SBC_1
247:251
AETST
SPOP
0.7259
More...
Q8WXI7
Mucin-16
DEG_SPOP_SBC_1
1658:1662
AETST
SPOP
0.7962
More...
Q8WXI7
Mucin-16
DEG_SPOP_SBC_1
10547:10551
AETST
SPOP
0.8453
More...
Q8WXI7
Mucin-16
DEG_SPOP_SBC_1
11582:11586
AETST
SPOP
0.734
More...
Q8WXI7
Mucin-16
DEG_SPOP_SBC_1
11808:11812
AETST
SPOP
0.8397
More...
Q8WXI7
Mucin-16
DEG_SPOP_SBC_1
11884:11888
AETST
SPOP
0.9518
More...
Q9HC84
Mucin-5B
DEG_SPOP_SBC_1
1758:1762
AETST
SPOP
0.8715
More...
Q9P0J7
E3 ubiquitin-protein ligase KCMF1
DEG_SPOP_SBC_1
102:106
AETST
SPOP
0.5697
More...