DegronMD

Uniprot ID: Q8WXI7

Source protein: Mucin-16

Source gene: MUC16

Class: DEG_SPOP_SBC_1

Location: 10547:10551

E3 ligase: SPOP

DEGRON score: 0.8453

ASA_SCORE: 96.86

COIL: 0.8544

CONS_SCORE: 0

DSS_SCORE: 0.5478

HELIX: 0.0256

FCONS_SCORE: 0

RIG_SCORE: 0.7175

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T10549S	TCGA-49-AARN	LUAD	TCGA	AETST	DEG_SPOP_SBC_1	0.6005
p.T10549S	DO218923	LUAD	ICGC	AETST	DEG_SPOP_SBC_1	0.6005
p.R10555M	TCGA-CG-5728	STAD	TCGA	AETST	DEG_SPOP_SBC_1	0.2222
p.R10555M	TCGA-DD-AACK	LIHC	TCGA	AETST	DEG_SPOP_SBC_1	0.2222
p.R10555M	DO52207	LIHC	ICGC	AETST	DEG_SPOP_SBC_1	0.2222
p.R10555M	DO38619	STAD	ICGC	AETST	DEG_SPOP_SBC_1	0.2222
p.T10557S	TCGA-DD-AACK	LIHC	TCGA	AETST	DEG_SPOP_SBC_1	0.1667
p.T10557S	DO52207	LIHC	ICGC	AETST	DEG_SPOP_SBC_1	0.1667
p.P10554S	TCGA-FS-A1ZW	SKCM	TCGA	AETST	DEG_SPOP_SBC_1	0.25
p.P10554S	TCGA-GF-A6C9	SKCM	TCGA	AETST	DEG_SPOP_SBC_1	0.25
p.P10554S	DO37519	SKCM	ICGC	AETST	DEG_SPOP_SBC_1	0.25
p.P10554S	DO51254	SKCM	ICGC	AETST	DEG_SPOP_SBC_1	0.25
p.A10547E	DO50342	ESAD	ICGC	AETST	DEG_SPOP_SBC_1	0.7701
p.G10546K	DO222731	MELA	ICGC	AETST	DEG_SPOP_SBC_1	0.3056
p.G10546R	DO222868	MELA	ICGC	AETST	DEG_SPOP_SBC_1	0.3056
p.A10547V	SIDM00377	Other Sarcomas	GDSC	AETST	DEG_SPOP_SBC_1	0.5825
p.A10547V	SIDM00411	Pancreatic Carcinoma	GDSC	AETST	DEG_SPOP_SBC_1	0.5825
p.A10547V	SIDM00247	Gastric Carcinoma	GDSC	AETST	DEG_SPOP_SBC_1	0.5825
p.A10547V	SIDM00023	Esophageal Squamous Cell Carcinoma	GDSC	AETST	DEG_SPOP_SBC_1	0.5825
p.A10547V	SIDM00271	Gastric Carcinoma	GDSC	AETST	DEG_SPOP_SBC_1	0.5825
p.A10547V	SIDM00986	Head and Neck Carcinoma	GDSC	AETST	DEG_SPOP_SBC_1	0.5825
p.A10547V	SIDM01033	Bladder Carcinoma	GDSC	AETST	DEG_SPOP_SBC_1	0.5825
p.L10553R	SIDM00190	Melanoma	GDSC	AETST	DEG_SPOP_SBC_1	0.2778
p.L10553R	ACH-002097	Skin Cancer	CCLE	AETST	DEG_SPOP_SBC_1	0.2778
p.L10553R	CP66-MEL	skin	COSMIC	AETST	DEG_SPOP_SBC_1	0.2778
p.S10540L	SIDM00871	Non-Cancerous	GDSC	AETST	DEG_SPOP_SBC_1	0.1389
p.S10540L	SIDM00872	Breast Carcinoma	GDSC	AETST	DEG_SPOP_SBC_1	0.1389
p.S10540L	ACH-000859	Breast Cancer	CCLE	AETST	DEG_SPOP_SBC_1	0.1389
p.S10540L	ACH-002384	Non-Cancerous	CCLE	AETST	DEG_SPOP_SBC_1	0.1389
p.T10556K	SIDM00579	Neuroblastoma	GDSC	AETST	DEG_SPOP_SBC_1	0.1944
p.T10556K	ACH-002277	Neuroblastoma	CCLE	AETST	DEG_SPOP_SBC_1	0.1944
p.T10556K	NB(TU)1-10	autonomic_ganglia	COSMIC	AETST	DEG_SPOP_SBC_1	0.1944
p.A10542S	SIDM00743	Non-Small Cell Lung Carcinoma	GDSC	AETST	DEG_SPOP_SBC_1	0.1944
p.A10542S	ACH-000448	Lung Cancer	CCLE	AETST	DEG_SPOP_SBC_1	0.1944
p.A10542S	NCI-H1666	lung	COSMIC	AETST	DEG_SPOP_SBC_1	0.1944

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: AETST

Degron related mutations and impact score

Drug responses associated with MUC16 mutations

All proteins holding degron of AETST

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8N157	Jouberin	DEG_SPOP_SBC_1	247:251	AETST	SPOP	0.7259	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	1658:1662	AETST	SPOP	0.7962	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	10547:10551	AETST	SPOP	0.8453	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	11582:11586	AETST	SPOP	0.734	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	11808:11812	AETST	SPOP	0.8397	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	11884:11888	AETST	SPOP	0.9518	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	1758:1762	AETST	SPOP	0.8715	More...
Q9P0J7	E3 ubiquitin-protein ligase KCMF1	DEG_SPOP_SBC_1	102:106	AETST	SPOP	0.5697	More...