DegronMD

Uniprot ID: Q8WXI7

Source protein: Mucin-16

Source gene: MUC16

Class: DEG_SPOP_SBC_1

Location: 11884:11888

E3 ligase: SPOP

DEGRON score: 0.9518

ASA_SCORE: 92.56

COIL: 0.7958

CONS_SCORE: 0

DSS_SCORE: 0.3683

HELIX: 0.0288

FCONS_SCORE: 0

RIG_SCORE: 0.7055

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S11896F	TCGA-D3-A3C7	SKCM	TCGA	AETST	DEG_SPOP_SBC_1	0.5556
p.S11896F	TCGA-EE-A2GP	SKCM	TCGA	AETST	DEG_SPOP_SBC_1	0.5556
p.S11896F	DO37422	SKCM	ICGC	AETST	DEG_SPOP_SBC_1	0.5556
p.S11896F	DO47569	SKCM	ICGC	AETST	DEG_SPOP_SBC_1	0.5556
p.T11892I	TCGA-D3-A3ML	SKCM	TCGA	AETST	DEG_SPOP_SBC_1	0.2222
p.T11892I	DO47413	SKCM	ICGC	AETST	DEG_SPOP_SBC_1	0.2222
p.G11876S	TCGA-EE-A29D	SKCM	TCGA	AETST	DEG_SPOP_SBC_1	0.1111
p.G11876S	DO38123	SKCM	ICGC	AETST	DEG_SPOP_SBC_1	0.1111
p.S11889I	TCGA-EO-A3AY	UCEC	TCGA	AETST	DEG_SPOP_SBC_1	0.75
p.S11889I	DO43202	UCEC	ICGC	AETST	DEG_SPOP_SBC_1	0.75
p.L11877V	TCGA-VQ-A8P2	STAD	TCGA	AETST	DEG_SPOP_SBC_1	0.1389
p.L11877V	DO51761	STAD	ICGC	AETST	DEG_SPOP_SBC_1	0.1389
p.A11898S	DO23272	LINC	ICGC	AETST	DEG_SPOP_SBC_1	0.0556
p.T11886S	DO50793	LIRI	ICGC	AETST	DEG_SPOP_SBC_1	0.7116
p.T11888R	SIDM01116	Non-Small Cell Lung Carcinoma	GDSC	AETST	DEG_SPOP_SBC_1	0.8987
p.T11888R	SIDM00454	Rhabdomyosarcoma	GDSC	AETST	DEG_SPOP_SBC_1	0.8987
p.T11894A	SIDM00537	Colorectal Carcinoma	GDSC	AETST	DEG_SPOP_SBC_1	0.1667
p.T11894A	GP5d	large_intestine	COSMIC	AETST	DEG_SPOP_SBC_1	0.1667
p.T11888A	ACH-001061	Colon/Colorectal Cancer	CCLE	AETST	DEG_SPOP_SBC_1	0.825

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8N157	Jouberin	DEG_SPOP_SBC_1	247:251	AETST	SPOP	0.7259	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	1658:1662	AETST	SPOP	0.7962	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	10547:10551	AETST	SPOP	0.8453	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	11582:11586	AETST	SPOP	0.734	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	11808:11812	AETST	SPOP	0.8397	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	11884:11888	AETST	SPOP	0.9518	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	1758:1762	AETST	SPOP	0.8715	More...
Q9P0J7	E3 ubiquitin-protein ligase KCMF1	DEG_SPOP_SBC_1	102:106	AETST	SPOP	0.5697	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons