DegronMD

Uniprot ID: Q9HC84

Source protein: Mucin-5B

Source gene: MUC5B

Class: DEG_SPOP_SBC_1

Location: 1758:1762

E3 ligase: SPOP

DEGRON score: 0.8715

ASA_SCORE: 94.44

COIL: 0.9006

CONS_SCORE: 0.4594

DSS_SCORE: 0.7206

HELIX: 0.0172

FCONS_SCORE: 1.268

RIG_SCORE: 0.6294

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A1758T	TCGA-2W-A8YY	CESC	TCGA	AETST	DEG_SPOP_SBC_1	0.7139
p.T1767M	TCGA-BB-4228	HNSC	TCGA	AETST	DEG_SPOP_SBC_1	0.1944
p.T1767M	SIDM01951	Colorectal Carcinoma	GDSC	AETST	DEG_SPOP_SBC_1	0.1944
p.E1752K	TCGA-RP-A693	SKCM	TCGA	AETST	DEG_SPOP_SBC_1	0.1667
p.A1761T	DO223732	CESC	ICGC	AETST	DEG_SPOP_SBC_1	0.7139
p.T1765M	DO230343	COCA	ICGC	AETST	DEG_SPOP_SBC_1	0.25
p.T1770M	DO15262	HNSC	ICGC	AETST	DEG_SPOP_SBC_1	0.1111
p.T1770M	DO49143	PACA	ICGC	AETST	DEG_SPOP_SBC_1	0.1111
p.E1762K	DO220860	MELA	ICGC	AETST	DEG_SPOP_SBC_1	0.7022
p.E1755K	DO51268	SKCM	ICGC	AETST	DEG_SPOP_SBC_1	0.25
p.T1748K	SIDM02010	Esophageal Carcinoma	GDSC	AETST	DEG_SPOP_SBC_1	0.0556
p.L1772F	SIDM00748	Non-Small Cell Lung Carcinoma	GDSC	AETST	DEG_SPOP_SBC_1	0.0556
p.L1772F	ACH-000015	Lung Cancer	CCLE	AETST	DEG_SPOP_SBC_1	0.0556
p.L1772F	NCI-H1581	lung	COSMIC	AETST	DEG_SPOP_SBC_1	0.0556
p.T1762M	SIDM00257	Neuroblastoma	GDSC	AETST	DEG_SPOP_SBC_1	0.7423
p.T1762M	SIDM00720	Mesothelioma	GDSC	AETST	DEG_SPOP_SBC_1	0.7423
p.T1762M	SIDM01387	Small Cell Lung Carcinoma	GDSC	AETST	DEG_SPOP_SBC_1	0.7423

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8N157	Jouberin	DEG_SPOP_SBC_1	247:251	AETST	SPOP	0.7259	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	1658:1662	AETST	SPOP	0.7962	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	10547:10551	AETST	SPOP	0.8453	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	11582:11586	AETST	SPOP	0.734	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	11808:11812	AETST	SPOP	0.8397	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	11884:11888	AETST	SPOP	0.9518	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	1758:1762	AETST	SPOP	0.8715	More...
Q9P0J7	E3 ubiquitin-protein ligase KCMF1	DEG_SPOP_SBC_1	102:106	AETST	SPOP	0.5697	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons