DegronMD

Uniprot ID: Q8WXI7

Source protein: Mucin-16

Source gene: MUC16

Class: DEG_SPOP_SBC_1

Location: 11808:11812

E3 ligase: SPOP

DEGRON score: 0.8397

ASA_SCORE: 94.74

COIL: 0.8304

CONS_SCORE: 0

DSS_SCORE: 0.5416

HELIX: 0.0208

FCONS_SCORE: 0

RIG_SCORE: 0.7241

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E11809Q	TCGA-AP-A0LF	UCEC	TCGA	AETST	DEG_SPOP_SBC_1	0.5633
p.E11809Q	DO43610	UCEC	ICGC	AETST	DEG_SPOP_SBC_1	0.5633
p.T11816A	TCGA-AX-A06F	UCEC	TCGA	AETST	DEG_SPOP_SBC_1	0.2222
p.T11816A	DO41752	UCEC	ICGC	AETST	DEG_SPOP_SBC_1	0.2222
p.G11807D	TCGA-EE-A2MK	SKCM	TCGA	AETST	DEG_SPOP_SBC_1	0.3056
p.G11807D	DO222615	MELA	ICGC	AETST	DEG_SPOP_SBC_1	0.3056
p.G11807D	DO38177	SKCM	ICGC	AETST	DEG_SPOP_SBC_1	0.3056
p.G11807A	DO233804	GACA	ICGC	AETST	DEG_SPOP_SBC_1	0.3056
p.A11808S	DO227648	PACA	ICGC	AETST	DEG_SPOP_SBC_1	0.7588
p.S11820P	DO35442	PACA	ICGC	AETST	DEG_SPOP_SBC_1	0.1111
p.A11800T	SIDM01030	Esophageal Squamous Cell Carcinoma	GDSC	AETST	DEG_SPOP_SBC_1	0.1111
p.A11800T	ACH-000693	Esophageal Cancer	CCLE	AETST	DEG_SPOP_SBC_1	0.1111
p.A11800T	KYSE-180	oesophagus	COSMIC	AETST	DEG_SPOP_SBC_1	0.1111
p.T11819S	SIDM00487	Colorectal Carcinoma	GDSC	AETST	DEG_SPOP_SBC_1	0.1389
p.T11819S	ACH-000963	Colon/Colorectal Cancer	CCLE	AETST	DEG_SPOP_SBC_1	0.1389
p.T11819S	CCK-81	large_intestine	COSMIC	AETST	DEG_SPOP_SBC_1	0.1389
p.Q11817H	SIDM00138	Non-Small Cell Lung Carcinoma	GDSC	AETST	DEG_SPOP_SBC_1	0.1944
p.Q11817H	ACH-000900	Lung Cancer	CCLE	AETST	DEG_SPOP_SBC_1	0.1944
p.Q11817H	NCI-H23	lung	COSMIC	AETST	DEG_SPOP_SBC_1	0.1944
p.T11803N	SIDM00220	Ovarian Carcinoma	GDSC	AETST	DEG_SPOP_SBC_1	0.1944
p.T11803N	ACH-000962	Ovarian Cancer	CCLE	AETST	DEG_SPOP_SBC_1	0.1944
p.T11803N	ACH-001145	Ovarian Cancer	CCLE	AETST	DEG_SPOP_SBC_1	0.1944
p.T11803N	OC-314	ovary	COSMIC	AETST	DEG_SPOP_SBC_1	0.1944
p.L11802V	ACH-000208	Brain Cancer	CCLE	AETST	DEG_SPOP_SBC_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8N157	Jouberin	DEG_SPOP_SBC_1	247:251	AETST	SPOP	0.7259	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	1658:1662	AETST	SPOP	0.7962	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	10547:10551	AETST	SPOP	0.8453	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	11582:11586	AETST	SPOP	0.734	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	11808:11812	AETST	SPOP	0.8397	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	11884:11888	AETST	SPOP	0.9518	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	1758:1762	AETST	SPOP	0.8715	More...
Q9P0J7	E3 ubiquitin-protein ligase KCMF1	DEG_SPOP_SBC_1	102:106	AETST	SPOP	0.5697	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons