DegronMD

Uniprot ID: Q8WXI7

Source protein: Mucin-16

Source gene: MUC16

Class: DEG_SPOP_SBC_1

Location: 11582:11586

E3 ligase: SPOP

DEGRON score: 0.734

ASA_SCORE: 94.72

COIL: 0.8738

CONS_SCORE: 0

DSS_SCORE: 0.5649

HELIX: 0.0184

FCONS_SCORE: 0

RIG_SCORE: 0.7226

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T11587M	TCGA-02-2485	GBM	TCGA	AETST	DEG_SPOP_SBC_1	0.3056
p.T11587M	TCGA-DU-A5TW	LGG	TCGA	AETST	DEG_SPOP_SBC_1	0.3056
p.T11587M	DO12742	GBM	ICGC	AETST	DEG_SPOP_SBC_1	0.3056
p.T11587M	DO44572	LGG	ICGC	AETST	DEG_SPOP_SBC_1	0.3056
p.N11594K	TCGA-34-5239	LUSC	TCGA	AETST	DEG_SPOP_SBC_1	0.1111
p.N11594K	TCGA-66-2742	LUSC	TCGA	AETST	DEG_SPOP_SBC_1	0.1111
p.N11594K	DO26439	LUSC	ICGC	AETST	DEG_SPOP_SBC_1	0.1111
p.N11594K	DO27660	LUSC	ICGC	AETST	DEG_SPOP_SBC_1	0.1111
p.T11591A	TCGA-AA-A010	COAD	TCGA	AETST	DEG_SPOP_SBC_1	0.1944
p.E11583D	TCGA-B5-A3FA	UCEC	TCGA	AETST	DEG_SPOP_SBC_1	0.5647
p.E11583D	DO52402	UCEC	ICGC	AETST	DEG_SPOP_SBC_1	0.5647
p.G11590W	TCGA-BF-A1PZ	SKCM	TCGA	AETST	DEG_SPOP_SBC_1	0.2222
p.G11590W	DO50279	SKCM	ICGC	AETST	DEG_SPOP_SBC_1	0.2222
p.N11594H	TCGA-D5-6932	COAD	TCGA	AETST	DEG_SPOP_SBC_1	0.1111
p.N11594H	DO9378	COAD	ICGC	AETST	DEG_SPOP_SBC_1	0.1111
p.P11593L	TCGA-EE-A2GC	SKCM	TCGA	AETST	DEG_SPOP_SBC_1	0.1389
p.P11593L	DO37839	SKCM	ICGC	AETST	DEG_SPOP_SBC_1	0.1389
p.A11575V	TCGA-FW-A3R5	SKCM	TCGA	AETST	DEG_SPOP_SBC_1	0.1389
p.A11575V	DO37406	SKCM	ICGC	AETST	DEG_SPOP_SBC_1	0.1389
p.T11586R	TCGA-GC-A4ZW	BLCA	TCGA	AETST	DEG_SPOP_SBC_1	0.7876
p.T11586R	DO219024	BLCA	ICGC	AETST	DEG_SPOP_SBC_1	0.7876
p.T11584N	TCGA-VS-A9U5	CESC	TCGA	AETST	DEG_SPOP_SBC_1	0.7055
p.T11584N	DO51641	CESC	ICGC	AETST	DEG_SPOP_SBC_1	0.7055
p.S11585R	DO229010	COCA	ICGC	AETST	DEG_SPOP_SBC_1	0.7427
p.S11585R	DO229016	COCA	ICGC	AETST	DEG_SPOP_SBC_1	0.7427
p.S11585R	DO229005	COCA	ICGC	AETST	DEG_SPOP_SBC_1	0.7427
p.S11585R	DO234205	ESAD	ICGC	AETST	DEG_SPOP_SBC_1	0.7427
p.S11585R	DO234285	ESAD	ICGC	AETST	DEG_SPOP_SBC_1	0.7427
p.S11585R	DO52365	LUSC	ICGC	AETST	DEG_SPOP_SBC_1	0.7427
p.E11583K	DO233746	GACA	ICGC	AETST	DEG_SPOP_SBC_1	0.591
p.T11576M	DO228947	LICA	ICGC	AETST	DEG_SPOP_SBC_1	0.1667
p.T11576M	SIDM00057	Neuroblastoma	GDSC	AETST	DEG_SPOP_SBC_1	0.1667
p.T11576M	SIDM00552	Rhabdomyosarcoma	GDSC	AETST	DEG_SPOP_SBC_1	0.1667
p.T11576M	KYM-1	soft_tissue	COSMIC	AETST	DEG_SPOP_SBC_1	0.1667
p.T11579N	DO229025	LICA	ICGC	AETST	DEG_SPOP_SBC_1	0.25
p.P11581S	DO220893	MELA	ICGC	AETST	DEG_SPOP_SBC_1	0.3056
p.S11596F	SIDM00545	Melanoma	GDSC	AETST	DEG_SPOP_SBC_1	0.0556
p.S11596F	ACH-000987	Skin Cancer	CCLE	AETST	DEG_SPOP_SBC_1	0.0556
p.S11596F	Mewo	skin	COSMIC	AETST	DEG_SPOP_SBC_1	0.0556
p.S11589F	SIDM01175	Other Sarcomas	GDSC	AETST	DEG_SPOP_SBC_1	0.25
p.S11589F	ACH-002309	Sarcoma	CCLE	AETST	DEG_SPOP_SBC_1	0.25
p.S11589F	SW684	soft_tissue	COSMIC	AETST	DEG_SPOP_SBC_1	0.25
p.A11575T	SIDM01007	T-Lymphoblastic Leukemia	GDSC	AETST	DEG_SPOP_SBC_1	0.1389
p.A11575T	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	AETST	DEG_SPOP_SBC_1	0.1389
p.L11578F	SIDM00516	Melanoma	GDSC	AETST	DEG_SPOP_SBC_1	0.2222
p.L11578F	ACH-002166	Skin Cancer	CCLE	AETST	DEG_SPOP_SBC_1	0.2222
p.L11578F	MZ7-mel	skin	COSMIC	AETST	DEG_SPOP_SBC_1	0.2222
p.H11580N	ACH-000975	Lung Cancer	CCLE	AETST	DEG_SPOP_SBC_1	0.2778

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: AETST

Degron related mutations and impact score

Drug responses associated with MUC16 mutations

All proteins holding degron of AETST

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8N157	Jouberin	DEG_SPOP_SBC_1	247:251	AETST	SPOP	0.7259	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	1658:1662	AETST	SPOP	0.7962	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	10547:10551	AETST	SPOP	0.8453	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	11582:11586	AETST	SPOP	0.734	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	11808:11812	AETST	SPOP	0.8397	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	11884:11888	AETST	SPOP	0.9518	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	1758:1762	AETST	SPOP	0.8715	More...
Q9P0J7	E3 ubiquitin-protein ligase KCMF1	DEG_SPOP_SBC_1	102:106	AETST	SPOP	0.5697	More...