DegronMD

Uniprot ID: Q86YS7

Source protein: C2 domain-containing protein 5

Source gene: C2CD5

Class: DEG_SCF_FBW7_1

Location: 182:188

E3 ligase: FBXW7

DEGRON score: 0.9307

ASA_SCORE: 78.4429

COIL: 0.75

CONS_SCORE: 0.7219

DSS_SCORE: 0.2746

HELIX: 0.209

FCONS_SCORE: 1.0686

RIG_SCORE: 0.7983

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R183C	TCGA-06-5416	GBM	TCGA	IRTPRAS	DEG_SCF_FBW7_1	0.719
p.R183C	TCGA-19-5956	GBM	TCGA	IRTPRAS	DEG_SCF_FBW7_1	0.719
p.R183C	TCGA-AA-3510	COAD	TCGA	IRTPRAS	DEG_SCF_FBW7_1	0.719
p.R183C	TCGA-AZ-4315	COAD	TCGA	IRTPRAS	DEG_SCF_FBW7_1	0.719
p.R183C	TCGA-D8-A1Y1	BRCA	TCGA	IRTPRAS	DEG_SCF_FBW7_1	0.719
p.R183C	TCGA-EY-A1G8	UCEC	TCGA	IRTPRAS	DEG_SCF_FBW7_1	0.719
p.R183C	TCGA-J2-A4AD	LUAD	TCGA	IRTPRAS	DEG_SCF_FBW7_1	0.719
p.R183C	DO1398	BRCA	ICGC	IRTPRAS	DEG_SCF_FBW7_1	0.719
p.R183C	DO7783	COAD	ICGC	IRTPRAS	DEG_SCF_FBW7_1	0.719
p.R183C	DO8842	COAD	ICGC	IRTPRAS	DEG_SCF_FBW7_1	0.719
p.R183C	DO13863	GBM	ICGC	IRTPRAS	DEG_SCF_FBW7_1	0.719
p.R183C	DO10880	GBM	ICGC	IRTPRAS	DEG_SCF_FBW7_1	0.719
p.R183C	DO23915	LUAD	ICGC	IRTPRAS	DEG_SCF_FBW7_1	0.719
p.R183C	DO43578	UCEC	ICGC	IRTPRAS	DEG_SCF_FBW7_1	0.719
p.R183C	ACH-000398	Lymphoma	CCLE	IRTPRAS	DEG_SCF_FBW7_1	0.719
p.R181Q	TCGA-A5-A2K5	UCEC	TCGA	IRTPRAS	DEG_SCF_FBW7_1	0.3056
p.R181Q	TCGA-AA-3510	COAD	TCGA	IRTPRAS	DEG_SCF_FBW7_1	0.3056
p.R181Q	TCGA-AA-3977	COAD	TCGA	IRTPRAS	DEG_SCF_FBW7_1	0.3056
p.R181Q	TCGA-AG-A002	READ	TCGA	IRTPRAS	DEG_SCF_FBW7_1	0.3056
p.R181Q	TCGA-AJ-A3EK	UCEC	TCGA	IRTPRAS	DEG_SCF_FBW7_1	0.3056
p.R181Q	TCGA-AJ-A5DW	UCEC	TCGA	IRTPRAS	DEG_SCF_FBW7_1	0.3056
p.R181Q	TCGA-AN-A046	BRCA	TCGA	IRTPRAS	DEG_SCF_FBW7_1	0.3056
p.R181Q	TCGA-D1-A16X	UCEC	TCGA	IRTPRAS	DEG_SCF_FBW7_1	0.3056
p.R181Q	TCGA-E2-A155	BRCA	TCGA	IRTPRAS	DEG_SCF_FBW7_1	0.3056
p.R181Q	TCGA-EI-6917	READ	TCGA	IRTPRAS	DEG_SCF_FBW7_1	0.3056
p.R181Q	TCGA-FU-A3HZ	CESC	TCGA	IRTPRAS	DEG_SCF_FBW7_1	0.3056
p.R181Q	TCGA-QF-A5YS	UCEC	TCGA	IRTPRAS	DEG_SCF_FBW7_1	0.3056
p.R181Q	DO1707	BRCA	ICGC	IRTPRAS	DEG_SCF_FBW7_1	0.3056
p.R181Q	DO1285	BRCA	ICGC	IRTPRAS	DEG_SCF_FBW7_1	0.3056
p.R181Q	DO6308	CESC	ICGC	IRTPRAS	DEG_SCF_FBW7_1	0.3056
p.R181Q	DO7783	COAD	ICGC	IRTPRAS	DEG_SCF_FBW7_1	0.3056
p.R181Q	DO8730	COAD	ICGC	IRTPRAS	DEG_SCF_FBW7_1	0.3056
p.R181Q	DO222798	COCA	ICGC	IRTPRAS	DEG_SCF_FBW7_1	0.3056
p.R181Q	DO229054	LICA	ICGC	IRTPRAS	DEG_SCF_FBW7_1	0.3056
p.R181Q	DO36881	READ	ICGC	IRTPRAS	DEG_SCF_FBW7_1	0.3056
p.R181Q	DO50075	UCEC	ICGC	IRTPRAS	DEG_SCF_FBW7_1	0.3056
p.R181Q	DO41584	UCEC	ICGC	IRTPRAS	DEG_SCF_FBW7_1	0.3056
p.R181Q	DO41799	UCEC	ICGC	IRTPRAS	DEG_SCF_FBW7_1	0.3056
p.R181Q	DO52426	UCEC	ICGC	IRTPRAS	DEG_SCF_FBW7_1	0.3056
p.R181Q	DO41379	UCEC	ICGC	IRTPRAS	DEG_SCF_FBW7_1	0.3056
p.R181Q	SIDM01611	Endometrial Carcinoma	GDSC	IRTPRAS	DEG_SCF_FBW7_1	0.3056
p.R181Q	SIDM01588	Endometrial Carcinoma	GDSC	IRTPRAS	DEG_SCF_FBW7_1	0.3056
p.R181Q	ACH-000993	Endometrial/Uterine Cancer	CCLE	IRTPRAS	DEG_SCF_FBW7_1	0.3056
p.R181Q	ACH-000996	Endometrial/Uterine Cancer	CCLE	IRTPRAS	DEG_SCF_FBW7_1	0.3056
p.R181Q	ACH-001991	Primary	CCLE	IRTPRAS	DEG_SCF_FBW7_1	0.3056
p.P174T	TCGA-AP-A1DK	UCEC	TCGA	IRTPRAS	DEG_SCF_FBW7_1	0.1111
p.P174T	DO42033	UCEC	ICGC	IRTPRAS	DEG_SCF_FBW7_1	0.1111
p.R192K	TCGA-DK-A6AW	BLCA	TCGA	IRTPRAS	DEG_SCF_FBW7_1	0.2222
p.R192K	DO48566	BLCA	ICGC	IRTPRAS	DEG_SCF_FBW7_1	0.2222
p.R183H	TCGA-FI-A2D5	UCEC	TCGA	IRTPRAS	DEG_SCF_FBW7_1	0.7133
p.R183H	DO9876	COAD	ICGC	IRTPRAS	DEG_SCF_FBW7_1	0.7133
p.R183H	DO41199	UCEC	ICGC	IRTPRAS	DEG_SCF_FBW7_1	0.7133
p.R183H	DO41331	UCEC	ICGC	IRTPRAS	DEG_SCF_FBW7_1	0.7133
p.R183H	SIDM00534	Colorectal Carcinoma	GDSC	IRTPRAS	DEG_SCF_FBW7_1	0.7133
p.R183H	ACH-000986	Colon/Colorectal Cancer	CCLE	IRTPRAS	DEG_SCF_FBW7_1	0.7133
p.R183H	HT-115	large_intestine	COSMIC	IRTPRAS	DEG_SCF_FBW7_1	0.7133
p.R186G	DO50445	ESAD	ICGC	IRTPRAS	DEG_SCF_FBW7_1	0.6457
p.D198Y	DO38635	STAD	ICGC	IRTPRAS	DEG_SCF_FBW7_1	0.0556
p.E190D	DO229204	THCA	ICGC	IRTPRAS	DEG_SCF_FBW7_1	0.2778
p.P185Q	ACH-000971	Colon/Colorectal Cancer	CCLE	IRTPRAS	DEG_SCF_FBW7_1	0.7035

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: IRTPRAS

Degron related mutations and impact score

Drug responses associated with C2CD5 mutations

All proteins holding degron of IRTPRAS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q86YS7	C2 domain-containing protein 5	DEG_SCF_FBW7_1	182:188	IRTPRAS	FBXW7	0.9307	More...