DegronMD

Uniprot ID: P18846

Source protein: Cyclic AMP-dependent transcription factor ATF-1

Source gene: ATF1

Class: DEG_SCF_FBW7_1

Location: 181:188

E3 ligase: FBXW7

DEGRON score: 0.9953

ASA_SCORE: 86.7625

COIL: 0.8046

CONS_SCORE: 0.544

DSS_SCORE: 0.4779

HELIX: 0.0371

FCONS_SCORE: 0.9822

RIG_SCORE: 0.7397

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R182Q	TCGA-BF-AAP7	SKCM	TCGA	IRTTPSAT	DEG_SCF_FBW7_1	0.6218
p.L190M	TCGA-CV-7415	HNSC	TCGA	IRTTPSAT	DEG_SCF_FBW7_1	0.2778
p.D175N	TCGA-ER-A193	SKCM	TCGA	IRTTPSAT	DEG_SCF_FBW7_1	0.1667
p.Q180H	TCGA-GM-A2DH	BRCA	TCGA	IRTTPSAT	DEG_SCF_FBW7_1	0.3056
p.R182L	SIDM01062	Breast Carcinoma	GDSC	IRTTPSAT	DEG_SCF_FBW7_1	0.7316
p.R182L	ACH-000643	Breast Cancer	CCLE	IRTTPSAT	DEG_SCF_FBW7_1	0.7316
p.R182L	HDQ-P1	breast	COSMIC	IRTTPSAT	DEG_SCF_FBW7_1	0.7316
p.R182G	SIDM00503	Gastric Carcinoma	GDSC	IRTTPSAT	DEG_SCF_FBW7_1	0.6457
p.R182G	ACH-000633	Gastric Cancer	CCLE	IRTTPSAT	DEG_SCF_FBW7_1	0.6457
p.R182G	FU97	stomach	COSMIC	IRTTPSAT	DEG_SCF_FBW7_1	0.6457

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P18846	Cyclic AMP-dependent transcription factor ATF-1	DEG_SCF_FBW7_1	181:188	IRTTPSAT	FBXW7	0.9953	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons