DegronMD - P18846(ATF1)

FUNCTION: This protein binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Binds to the Tax-responsive element (TRE) of HTLV-I. Mediates PKA-induced stimulation of CRE-reporter genes. Represses the expression of FTH1 and other antioxidant detoxification genes. Triggers cell proliferation and transformation. {ECO:0000269|PubMed:18794154, ECO:0000269|PubMed:20980392}.

GO - Biological processes (BP): cAMP-mediated signaling [GO:0019933]; positive regulation of DNA replication [GO:0045740]; positive regulation of neuron projection development [GO:0010976]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]; respons... View more >>

GO - Molecular function (MF): DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; identical protein binding [GO:0042802]; protein-containing complex bindin... View more >>

GO - Cellular component (CC): ATF1-ATF4 transcription factor complex [GO:1990590]; ATF4-CREB1 transcription factor complex [GO:1990589]; chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA polymerase II transcription regulator complex [GO:0090575]; transcription regulator complex [GO:0005667]

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Degron hit	Class	E3 ligase	Source protein	Location	Detail
YRKILKDLS	DEG_APCC_DBOX_1	APC,CDC20,FZR1	Cyclic AMP-dependent transcription factor ATF-1	64:72	More..
TSMSVPTP	DEG_COP1_1	COP1	Cyclic AMP-dependent transcription factor ATF-1	93:100	More..
IRTTPSAT	DEG_SCF_FBW7_1	FBXW7	Cyclic AMP-dependent transcription factor ATF-1	181:188	More..

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.C95R	DO228305	MALY	ICGC	TSMSVPTP	DEG_COP1_1	93:100	Mutation altering degron motif	0.8301
p.R96H	DO232761	PBCA	ICGC	TSMSVPTP	DEG_COP1_1	93:100	Mutation altering degron motif	0.8244
p.R93G	DO32507	OV	ICGC	TSMSVPTP	DEG_COP1_1	93:100	Mutation altering degron motif	0.7568
p.R182L	SIDM01062	Breast Carcinoma	GDSC	IRTTPSAT	DEG_SCF_FBW7_1	181:188	Mutation altering degron motif	0.7316
p.R182L	ACH-000643	Breast Cancer	CCLE	IRTTPSAT	DEG_SCF_FBW7_1	181:188	Mutation altering degron motif	0.7316
p.R182L	HDQ-P1	breast	COSMIC	IRTTPSAT	DEG_SCF_FBW7_1	181:188	Mutation altering degron motif	0.7316
p.Y64C	DO229253	THCA	ICGC	YRKILKDLS	DEG_APCC_DBOX_1	64:72	Mutation altering degron motif	0.7087
p.L68V	DO230313	COCA	ICGC	YRKILKDLS	DEG_APCC_DBOX_1	64:72	Mutation altering degron motif	0.6765
p.R182G	SIDM00503	Gastric Carcinoma	GDSC	IRTTPSAT	DEG_SCF_FBW7_1	181:188	Mutation altering degron motif	0.6457
p.R182G	ACH-000633	Gastric Cancer	CCLE	IRTTPSAT	DEG_SCF_FBW7_1	181:188	Mutation altering degron motif	0.6457
p.R182G	FU97	stomach	COSMIC	IRTTPSAT	DEG_SCF_FBW7_1	181:188	Mutation altering degron motif	0.6457
p.I67F	SIDM00150	Colorectal Carcinoma	GDSC	YRKILKDLS	DEG_APCC_DBOX_1	64:72	Mutation altering degron motif	0.6304
p.I67F	ACH-000969	Colon/Colorectal Cancer	CCLE	YRKILKDLS	DEG_APCC_DBOX_1	64:72	Mutation altering degron motif	0.6304
p.R182Q	TCGA-BF-AAP7	SKCM	TCGA	IRTTPSAT	DEG_SCF_FBW7_1	181:188	Mutation altering degron motif	0.6218
p.D70Y	DO50678	ORCA	ICGC	YRKILKDLS	DEG_APCC_DBOX_1	64:72	Mutation altering degron motif	0.6214
p.L71I	TCGA-13-1507	OV	TCGA	YRKILKDLS	DEG_APCC_DBOX_1	64:72	Mutation altering degron motif	0.6063
p.L71I	DO27991	OV	ICGC	YRKILKDLS	DEG_APCC_DBOX_1	64:72	Mutation altering degron motif	0.6063
p.Q180H	TCGA-GM-A2DH	BRCA	TCGA	IRTTPSAT	DEG_SCF_FBW7_1	181:188	Mutation rewiring degron network	0.3056
p.E101G	DO15727	HNSC	ICGC	TSMSVPTP	DEG_COP1_1	93:100	Mutation rewiring degron network	0.3056
p.L190M	TCGA-CV-7415	HNSC	TCGA	IRTTPSAT	DEG_SCF_FBW7_1	181:188	Mutation rewiring degron network	0.2778

Showing 1 to 20 of 53 entries

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No resistance data available for this Degron.

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

ATF1

UniProt ID: P18846

Entrez ID: 466

Protein name: Cyclic AMP-dependent transcription factor ATF-1 (cAMP-dependent transcription factor ATF-1) (Activating transcription factor 1) (Protein TREB36)

External links: UniprotKB HGNC RefSeq COSMIC

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No resistance data available for this Degron.

Kaplan plot for ATF1 in