DegronMD - P18846(ATF1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.L71I	TCGA-13-1507	OV	TCGA	YRKILKDLS	DEG_APCC_DBOX_1	64:72	Mutation altering degron motif	0.6063
p.L71I	DO27991	OV	ICGC	YRKILKDLS	DEG_APCC_DBOX_1	64:72	Mutation altering degron motif	0.6063
p.S86Y	TCGA-19-5956	GBM	TCGA	TSMSVPTP	DEG_COP1_1	93:100	Mutation rewiring degron network	0.1389
p.S86Y	DO13863	GBM	ICGC	TSMSVPTP	DEG_COP1_1	93:100	Mutation rewiring degron network	0.1389
p.G83A	TCGA-3H-AB3X	MESO	TCGA	TSMSVPTP	DEG_COP1_1	93:100	Mutation rewiring degron network	0.0556
p.D82V	TCGA-55-8620	LUAD	TCGA	YRKILKDLS	DEG_APCC_DBOX_1	64:72	Mutation rewiring degron network	0.0556
p.D82V	DO24547	LUAD	ICGC	YRKILKDLS	DEG_APCC_DBOX_1	64:72	Mutation rewiring degron network	0.0556
p.R182Q	TCGA-BF-AAP7	SKCM	TCGA	IRTTPSAT	DEG_SCF_FBW7_1	181:188	Mutation altering degron motif	0.6218
p.I110S	TCGA-CA-6717	COAD	TCGA	TSMSVPTP	DEG_COP1_1	93:100	Mutation rewiring degron network	0.0556
p.L190M	TCGA-CV-7415	HNSC	TCGA	IRTTPSAT	DEG_SCF_FBW7_1	181:188	Mutation rewiring degron network	0.2778
p.Y102C	TCGA-D8-A1XA	BRCA	TCGA	TSMSVPTP	DEG_COP1_1	93:100	Mutation rewiring degron network	0.2778
p.Y102C	DO4683	BRCA	ICGC	TSMSVPTP	DEG_COP1_1	93:100	Mutation rewiring degron network	0.2778
p.T76I	TCGA-DF-A2KU	UCEC	TCGA	YRKILKDLS	DEG_APCC_DBOX_1	64:72	Mutation rewiring degron network	0.2222
p.T76I	DO223286	UCEC	ICGC	YRKILKDLS	DEG_APCC_DBOX_1	64:72	Mutation rewiring degron network	0.2222
p.D175N	TCGA-ER-A193	SKCM	TCGA	IRTTPSAT	DEG_SCF_FBW7_1	181:188	Mutation rewiring degron network	0.1667
p.Q180H	TCGA-GM-A2DH	BRCA	TCGA	IRTTPSAT	DEG_SCF_FBW7_1	181:188	Mutation rewiring degron network	0.3056
p.A91D	TCGA-IB-7651	PAAD	TCGA	TSMSVPTP	DEG_COP1_1	93:100	Mutation rewiring degron network	0.2778
p.A91D	DO46657	PAAD	ICGC	TSMSVPTP	DEG_COP1_1	93:100	Mutation rewiring degron network	0.2778
p.L68V	DO230313	COCA	ICGC	YRKILKDLS	DEG_APCC_DBOX_1	64:72	Mutation altering degron motif	0.6765
p.L55M	DO14926	HNSC	ICGC	YRKILKDLS	DEG_APCC_DBOX_1	64:72	Mutation rewiring degron network	0.0833
p.E101G	DO15727	HNSC	ICGC	TSMSVPTP	DEG_COP1_1	93:100	Mutation rewiring degron network	0.3056
p.V59L	DO228974	LICA	ICGC	YRKILKDLS	DEG_APCC_DBOX_1	64:72	Mutation rewiring degron network	0.1944
p.S105I	DO229025	LICA	ICGC	TSMSVPTP	DEG_COP1_1	93:100	Mutation rewiring degron network	0.1944
p.V103L	DO229035	LICA	ICGC	TSMSVPTP	DEG_COP1_1	93:100	Mutation rewiring degron network	0.25
p.V103L	DO229038	LICA	ICGC	TSMSVPTP	DEG_COP1_1	93:100	Mutation rewiring degron network	0.25
p.M86I	DO230961	LUSC	ICGC	TSMSVPTP	DEG_COP1_1	93:100	Mutation rewiring degron network	0.1389
p.M86I	DO224594	LUSC	ICGC	TSMSVPTP	DEG_COP1_1	93:100	Mutation rewiring degron network	0.1389
p.C95R	DO228305	MALY	ICGC	TSMSVPTP	DEG_COP1_1	93:100	Mutation altering degron motif	0.8301
p.D70Y	DO50678	ORCA	ICGC	YRKILKDLS	DEG_APCC_DBOX_1	64:72	Mutation altering degron motif	0.6214
p.L79F	DO27987	OV	ICGC	YRKILKDLS	DEG_APCC_DBOX_1	64:72	Mutation rewiring degron network	0.1389
p.R93G	DO32507	OV	ICGC	TSMSVPTP	DEG_COP1_1	93:100	Mutation altering degron motif	0.7568
p.R61H	DO51500	PACA	ICGC	YRKILKDLS	DEG_APCC_DBOX_1	64:72	Mutation rewiring degron network	0.25
p.R61H	SIDM02059	Colorectal Carcinoma	GDSC	YRKILKDLS	DEG_APCC_DBOX_1	64:72	Mutation rewiring degron network	0.25
p.R96H	DO232761	PBCA	ICGC	TSMSVPTP	DEG_COP1_1	93:100	Mutation altering degron motif	0.8244
p.P77H	DO37731	SKCM	ICGC	YRKILKDLS	DEG_APCC_DBOX_1	64:72	Mutation rewiring degron network	0.1944
p.L85F	DO37427	SKCM	ICGC	TSMSVPTP	DEG_COP1_1	93:100	Mutation rewiring degron network	0.1111
p.Y64C	DO229253	THCA	ICGC	YRKILKDLS	DEG_APCC_DBOX_1	64:72	Mutation altering degron motif	0.7087
p.R81T	DO43787	UCEC	ICGC	YRKILKDLS	DEG_APCC_DBOX_1	64:72	Mutation rewiring degron network	0.0833
p.R182L	SIDM01062	Breast Carcinoma	GDSC	IRTTPSAT	DEG_SCF_FBW7_1	181:188	Mutation altering degron motif	0.7316
p.R182L	ACH-000643	Breast Cancer	CCLE	IRTTPSAT	DEG_SCF_FBW7_1	181:188	Mutation altering degron motif	0.7316
p.R182L	HDQ-P1	breast	COSMIC	IRTTPSAT	DEG_SCF_FBW7_1	181:188	Mutation altering degron motif	0.7316
p.G83R	SIDM00183	Small Cell Lung Carcinoma	GDSC	TSMSVPTP	DEG_COP1_1	93:100	Mutation rewiring degron network	0.0556
p.G83R	SIDM01648	Non-Cancerous	GDSC	TSMSVPTP	DEG_COP1_1	93:100	Mutation rewiring degron network	0.0556
p.R182G	SIDM00503	Gastric Carcinoma	GDSC	IRTTPSAT	DEG_SCF_FBW7_1	181:188	Mutation altering degron motif	0.6457
p.R182G	ACH-000633	Gastric Cancer	CCLE	IRTTPSAT	DEG_SCF_FBW7_1	181:188	Mutation altering degron motif	0.6457
p.R182G	FU97	stomach	COSMIC	IRTTPSAT	DEG_SCF_FBW7_1	181:188	Mutation altering degron motif	0.6457
p.I67F	SIDM00150	Colorectal Carcinoma	GDSC	YRKILKDLS	DEG_APCC_DBOX_1	64:72	Mutation altering degron motif	0.6304
p.I67F	ACH-000969	Colon/Colorectal Cancer	CCLE	YRKILKDLS	DEG_APCC_DBOX_1	64:72	Mutation altering degron motif	0.6304
p.P62L	SIDM01450	Gastric Carcinoma	GDSC	YRKILKDLS	DEG_APCC_DBOX_1	64:72	Mutation rewiring degron network	0.2778
p.P62L	ACH-000898	Gastric Cancer	CCLE	YRKILKDLS	DEG_APCC_DBOX_1	64:72	Mutation rewiring degron network	0.2778
p.R77W	SIDM01580	Melanoma	GDSC	YRKILKDLS	DEG_APCC_DBOX_1	64:72	Mutation rewiring degron network	0.1944
p.R77W	ACH-000240	Non-Cancerous	CCLE	YRKILKDLS	DEG_APCC_DBOX_1	64:72	Mutation rewiring degron network	0.1944
p.R60Q	ACH-001197	Lymphoma	CCLE	YRKILKDLS	DEG_APCC_DBOX_1	64:72	Mutation rewiring degron network	0.2222

Kaplan plot for ATF1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ATF1

UniProt ID: P18846

Entrez ID: 466

Protein name: Cyclic AMP-dependent transcription factor ATF-1 (cAMP-dependent transcription factor ATF-1) (Activating transcription factor 1) (Protein TREB36)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ATF1 in