DegronMD

Uniprot ID: P18846

Source protein: Cyclic AMP-dependent transcription factor ATF-1

Source gene: ATF1

Class: DEG_APCC_DBOX_1

Location: 64:72

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9426

ASA_SCORE: 71.8556

COIL: 0.2989

CONS_SCORE: 0.5895

DSS_SCORE: 0.5363

HELIX: 0.6908

FCONS_SCORE: 1.0295

RIG_SCORE: 0.7582

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L71I	TCGA-13-1507	OV	TCGA	YRKILKDLS	DEG_APCC_DBOX_1	0.6063
p.L71I	DO27991	OV	ICGC	YRKILKDLS	DEG_APCC_DBOX_1	0.6063
p.D82V	TCGA-55-8620	LUAD	TCGA	YRKILKDLS	DEG_APCC_DBOX_1	0.0556
p.D82V	DO24547	LUAD	ICGC	YRKILKDLS	DEG_APCC_DBOX_1	0.0556
p.T76I	TCGA-DF-A2KU	UCEC	TCGA	YRKILKDLS	DEG_APCC_DBOX_1	0.2222
p.T76I	DO223286	UCEC	ICGC	YRKILKDLS	DEG_APCC_DBOX_1	0.2222
p.L68V	DO230313	COCA	ICGC	YRKILKDLS	DEG_APCC_DBOX_1	0.6765
p.L55M	DO14926	HNSC	ICGC	YRKILKDLS	DEG_APCC_DBOX_1	0.0833
p.V59L	DO228974	LICA	ICGC	YRKILKDLS	DEG_APCC_DBOX_1	0.1944
p.D70Y	DO50678	ORCA	ICGC	YRKILKDLS	DEG_APCC_DBOX_1	0.6214
p.L79F	DO27987	OV	ICGC	YRKILKDLS	DEG_APCC_DBOX_1	0.1389
p.R61H	DO51500	PACA	ICGC	YRKILKDLS	DEG_APCC_DBOX_1	0.25
p.R61H	SIDM02059	Colorectal Carcinoma	GDSC	YRKILKDLS	DEG_APCC_DBOX_1	0.25
p.P77H	DO37731	SKCM	ICGC	YRKILKDLS	DEG_APCC_DBOX_1	0.1944
p.Y64C	DO229253	THCA	ICGC	YRKILKDLS	DEG_APCC_DBOX_1	0.7087
p.R81T	DO43787	UCEC	ICGC	YRKILKDLS	DEG_APCC_DBOX_1	0.0833
p.I67F	SIDM00150	Colorectal Carcinoma	GDSC	YRKILKDLS	DEG_APCC_DBOX_1	0.6304
p.I67F	ACH-000969	Colon/Colorectal Cancer	CCLE	YRKILKDLS	DEG_APCC_DBOX_1	0.6304
p.P62L	SIDM01450	Gastric Carcinoma	GDSC	YRKILKDLS	DEG_APCC_DBOX_1	0.2778
p.P62L	ACH-000898	Gastric Cancer	CCLE	YRKILKDLS	DEG_APCC_DBOX_1	0.2778
p.R77W	SIDM01580	Melanoma	GDSC	YRKILKDLS	DEG_APCC_DBOX_1	0.1944
p.R77W	ACH-000240	Non-Cancerous	CCLE	YRKILKDLS	DEG_APCC_DBOX_1	0.1944
p.R60Q	ACH-001197	Lymphoma	CCLE	YRKILKDLS	DEG_APCC_DBOX_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P18846	Cyclic AMP-dependent transcription factor ATF-1	DEG_APCC_DBOX_1	64:72	YRKILKDLS	APC,CDC20,FZR1	0.9426	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons