DegronMD

Uniprot ID: P18846

Source protein: Cyclic AMP-dependent transcription factor ATF-1

Source gene: ATF1

Class: DEG_COP1_1

Location: 93:100

E3 ligase: COP1

DEGRON score: 0.995

ASA_SCORE: 80.7625

COIL: 0.9136

CONS_SCORE: 0.5725

DSS_SCORE: 0.4139

HELIX: 0.0199

FCONS_SCORE: 1.1011

RIG_SCORE: 0.7313

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S86Y	TCGA-19-5956	GBM	TCGA	TSMSVPTP	DEG_COP1_1	0.1389
p.S86Y	DO13863	GBM	ICGC	TSMSVPTP	DEG_COP1_1	0.1389
p.G83A	TCGA-3H-AB3X	MESO	TCGA	TSMSVPTP	DEG_COP1_1	0.0556
p.I110S	TCGA-CA-6717	COAD	TCGA	TSMSVPTP	DEG_COP1_1	0.0556
p.Y102C	TCGA-D8-A1XA	BRCA	TCGA	TSMSVPTP	DEG_COP1_1	0.2778
p.Y102C	DO4683	BRCA	ICGC	TSMSVPTP	DEG_COP1_1	0.2778
p.A91D	TCGA-IB-7651	PAAD	TCGA	TSMSVPTP	DEG_COP1_1	0.2778
p.A91D	DO46657	PAAD	ICGC	TSMSVPTP	DEG_COP1_1	0.2778
p.E101G	DO15727	HNSC	ICGC	TSMSVPTP	DEG_COP1_1	0.3056
p.S105I	DO229025	LICA	ICGC	TSMSVPTP	DEG_COP1_1	0.1944
p.V103L	DO229035	LICA	ICGC	TSMSVPTP	DEG_COP1_1	0.25
p.V103L	DO229038	LICA	ICGC	TSMSVPTP	DEG_COP1_1	0.25
p.M86I	DO230961	LUSC	ICGC	TSMSVPTP	DEG_COP1_1	0.1389
p.M86I	DO224594	LUSC	ICGC	TSMSVPTP	DEG_COP1_1	0.1389
p.C95R	DO228305	MALY	ICGC	TSMSVPTP	DEG_COP1_1	0.8301
p.R93G	DO32507	OV	ICGC	TSMSVPTP	DEG_COP1_1	0.7568
p.R96H	DO232761	PBCA	ICGC	TSMSVPTP	DEG_COP1_1	0.8244
p.L85F	DO37427	SKCM	ICGC	TSMSVPTP	DEG_COP1_1	0.1111
p.G83R	SIDM00183	Small Cell Lung Carcinoma	GDSC	TSMSVPTP	DEG_COP1_1	0.0556
p.G83R	SIDM01648	Non-Cancerous	GDSC	TSMSVPTP	DEG_COP1_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P18846	Cyclic AMP-dependent transcription factor ATF-1	DEG_COP1_1	93:100	TSMSVPTP	COP1	0.995	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons