DegronMD

Uniprot ID: A6H8Z2

Source protein: Protein FAM221B

Source gene: FAM221B

Class: DEG_SCF_FBW7_1

Location: 80:87

E3 ligase: FBXW7

DEGRON score: 0.9965

ASA_SCORE: 99.175

COIL: 0.969

CONS_SCORE: 0.3753

DSS_SCORE: 0.7915

HELIX: 0.0125

FCONS_SCORE: 1.2202

RIG_SCORE: 0.5691

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E86D	TCGA-3M-AB46	STAD	TCGA	ISETPSET	DEG_SCF_FBW7_1	0.5647
p.E86D	DO222326	STAD	ICGC	ISETPSET	DEG_SCF_FBW7_1	0.5647
p.T74I	TCGA-B5-A3FC	UCEC	TCGA	ISETPSET	DEG_SCF_FBW7_1	0.1667
p.T74I	DO41871	UCEC	ICGC	ISETPSET	DEG_SCF_FBW7_1	0.1667
p.E82K	TCGA-ZF-AA4V	BLCA	TCGA	ISETPSET	DEG_SCF_FBW7_1	0.591
p.E82K	DO219087	BLCA	ICGC	ISETPSET	DEG_SCF_FBW7_1	0.591
p.L94S	SIDM01018	Hodgkin's Lymphoma	GDSC	ISETPSET	DEG_SCF_FBW7_1	0.1389
p.L94S	SIDM01779	Gastric Carcinoma	GDSC	ISETPSET	DEG_SCF_FBW7_1	0.1389
p.L94S	KM-H2	haematopoietic_and_lymphoid_tissue	COSMIC	ISETPSET	DEG_SCF_FBW7_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A6H8Z2	Protein FAM221B	DEG_SCF_FBW7_1	80:87	ISETPSET	FBXW7	0.9965	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons