DegronMD - A6H8Z2(FAM221B)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E86D	TCGA-3M-AB46	STAD	TCGA	ISETPSET	DEG_SCF_FBW7_1	80:87	Mutation altering degron motif	0.5647
p.E86D	TCGA-3M-AB46	STAD	TCGA	PSETPTYE	DEG_SCF_FBW7_2	84:91	Mutation altering degron motif	0.5647
p.E86D	DO222326	STAD	ICGC	ISETPSET	DEG_SCF_FBW7_1	80:87	Mutation altering degron motif	0.5647
p.E86D	DO222326	STAD	ICGC	PSETPTYE	DEG_SCF_FBW7_2	84:91	Mutation altering degron motif	0.5647
p.T74I	TCGA-B5-A3FC	UCEC	TCGA	ISETPSET	DEG_SCF_FBW7_1	80:87	Mutation rewiring degron network	0.1667
p.T74I	TCGA-B5-A3FC	UCEC	TCGA	PSETPTYE	DEG_SCF_FBW7_2	84:91	Mutation rewiring degron network	0.0556
p.T74I	DO41871	UCEC	ICGC	ISETPSET	DEG_SCF_FBW7_1	80:87	Mutation rewiring degron network	0.1667
p.T74I	DO41871	UCEC	ICGC	PSETPTYE	DEG_SCF_FBW7_2	84:91	Mutation rewiring degron network	0.0556
p.L67S	TCGA-VQ-A8P2	STAD	TCGA	TSESPLVPSP	DEG_COP1_1	53:62	Mutation rewiring degron network	0.1944
p.L67S	DO51761	STAD	ICGC	TSESPLVPSP	DEG_COP1_1	53:62	Mutation rewiring degron network	0.1944
p.E82K	TCGA-ZF-AA4V	BLCA	TCGA	ISETPSET	DEG_SCF_FBW7_1	80:87	Mutation altering degron motif	0.591
p.E82K	DO219087	BLCA	ICGC	ISETPSET	DEG_SCF_FBW7_1	80:87	Mutation altering degron motif	0.591
p.P51T	DO229019	LICA	ICGC	TSESPLVPSP	DEG_COP1_1	53:62	Mutation rewiring degron network	0.2778
p.P57A	DO50725	ORCA	ICGC	TSESPLVPSP	DEG_COP1_1	53:62	Mutation altering degron motif	0.6392
p.P57A	DO34736	PACA	ICGC	TSESPLVPSP	DEG_COP1_1	53:62	Mutation altering degron motif	0.6392
p.P48L	SIDM00718	Non-Small Cell Lung Carcinoma	GDSC	TSESPLVPSP	DEG_COP1_1	53:62	Mutation rewiring degron network	0.1944
p.L94S	SIDM01018	Hodgkin's Lymphoma	GDSC	ISETPSET	DEG_SCF_FBW7_1	80:87	Mutation rewiring degron network	0.1389
p.L94S	SIDM01018	Hodgkin's Lymphoma	GDSC	PSETPTYE	DEG_SCF_FBW7_2	84:91	Mutation rewiring degron network	0.25
p.L94S	SIDM01779	Gastric Carcinoma	GDSC	ISETPSET	DEG_SCF_FBW7_1	80:87	Mutation rewiring degron network	0.1389
p.L94S	SIDM01779	Gastric Carcinoma	GDSC	PSETPTYE	DEG_SCF_FBW7_2	84:91	Mutation rewiring degron network	0.25
p.L94S	KM-H2	haematopoietic and lymphoid tissue	COSMIC	ISETPSET	DEG_SCF_FBW7_1	80:87	Mutation rewiring degron network	0.1389
p.L94S	KM-H2	haematopoietic and lymphoid tissue	COSMIC	PSETPTYE	DEG_SCF_FBW7_2	84:91	Mutation rewiring degron network	0.25

DegronMD: protein-targeted degradation, mutation and drug response to degrons

FAM221B

UniProt ID: A6H8Z2

Entrez ID: 392307

Protein name: Protein FAM221B

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for FAM221B in