DegronMD

Uniprot ID: A6H8Z2

Source protein: Protein FAM221B

Source gene: FAM221B

Class: DEG_COP1_1

Location: 53:62

E3 ligase: COP1

DEGRON score: 0.8203

ASA_SCORE: 96.67

COIL: 0.9644

CONS_SCORE: 0.2545

DSS_SCORE: 0.7868

HELIX: 0.0143

FCONS_SCORE: 0.8577

RIG_SCORE: 0.5685

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L67S	TCGA-VQ-A8P2	STAD	TCGA	TSESPLVPSP	DEG_COP1_1	0.1944
p.L67S	DO51761	STAD	ICGC	TSESPLVPSP	DEG_COP1_1	0.1944
p.P51T	DO229019	LICA	ICGC	TSESPLVPSP	DEG_COP1_1	0.2778
p.P57A	DO50725	ORCA	ICGC	TSESPLVPSP	DEG_COP1_1	0.6392
p.P57A	DO34736	PACA	ICGC	TSESPLVPSP	DEG_COP1_1	0.6392
p.P48L	SIDM00718	Non-Small Cell Lung Carcinoma	GDSC	TSESPLVPSP	DEG_COP1_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A6H8Z2	Protein FAM221B	DEG_COP1_1	53:62	TSESPLVPSP	COP1	0.8203	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons