DegronMD

Uniprot ID: A6H8Z2

Source protein: Protein FAM221B

Source gene: FAM221B

Class: DEG_SCF_FBW7_2

Location: 84:91

E3 ligase: FBXW7

DEGRON score: 0.7558

ASA_SCORE: 104.6875

COIL: 0.9445

CONS_SCORE: 0.2961

DSS_SCORE: 0.707

HELIX: 0.0281

FCONS_SCORE: 0.8949

RIG_SCORE: 0.6108

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E86D	TCGA-3M-AB46	STAD	TCGA	PSETPTYE	DEG_SCF_FBW7_2	0.5647
p.E86D	DO222326	STAD	ICGC	PSETPTYE	DEG_SCF_FBW7_2	0.5647
p.T74I	TCGA-B5-A3FC	UCEC	TCGA	PSETPTYE	DEG_SCF_FBW7_2	0.0556
p.T74I	DO41871	UCEC	ICGC	PSETPTYE	DEG_SCF_FBW7_2	0.0556
p.L94S	SIDM01018	Hodgkin's Lymphoma	GDSC	PSETPTYE	DEG_SCF_FBW7_2	0.25
p.L94S	SIDM01779	Gastric Carcinoma	GDSC	PSETPTYE	DEG_SCF_FBW7_2	0.25
p.L94S	KM-H2	haematopoietic_and_lymphoid_tissue	COSMIC	PSETPTYE	DEG_SCF_FBW7_2	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A6H8Z2	Protein FAM221B	DEG_SCF_FBW7_2	84:91	PSETPTYE	FBXW7	0.7558	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons