DegronMD

Uniprot ID: A6NKC9

Source protein: SH2 domain-containing protein 7

Source gene: SH2D7

Class: DEG_SCF_FBW7_1

Location: 406:413

E3 ligase: FBXW7

DEGRON score: 0.9506

ASA_SCORE: 78.7125

COIL: 0.8946

CONS_SCORE: 0.3812

DSS_SCORE: 0.5313

HELIX: 0.0273

FCONS_SCORE: 0.9965

RIG_SCORE: 0.6432

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T409I	TCGA-YD-A89C	SKCM	TCGA	ISGTPELS	DEG_SCF_FBW7_1	0.7078
p.T409I	DO219501	SKCM	ICGC	ISGTPELS	DEG_SCF_FBW7_1	0.7078
p.S407L	TCGA-ZF-A9RC	BLCA	TCGA	ISGTPELS	DEG_SCF_FBW7_1	0.6556
p.S407L	DO219068	BLCA	ICGC	ISGTPELS	DEG_SCF_FBW7_1	0.6556
p.Q421K	DO233749	GACA	ICGC	ISGTPELS	DEG_SCF_FBW7_1	0.1111
p.I422T	SIDM00608	Plasma Cell Myeloma	GDSC	ISGTPELS	DEG_SCF_FBW7_1	0.0833
p.I422T	ACH-000714	Myeloma	CCLE	ISGTPELS	DEG_SCF_FBW7_1	0.0833
p.I422T	KMS-11	haematopoietic_and_lymphoid_tissue	COSMIC	ISGTPELS	DEG_SCF_FBW7_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A6NKC9	SH2 domain-containing protein 7	DEG_SCF_FBW7_1	406:413	ISGTPELS	FBXW7	0.9506	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons