DegronMD - A6NKC9(SH2D7)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P133H	TCGA-38-4632	LUAD	TCGA	LEPFKE	LIG_APCC_ABBA_1	131:136	Mutation altering degron motif	0.7694
p.P133H	DO23858	LUAD	ICGC	LEPFKE	LIG_APCC_ABBA_1	131:136	Mutation altering degron motif	0.7694
p.Q127K	TCGA-D3-A1QB	SKCM	TCGA	LEPFKE	LIG_APCC_ABBA_1	131:136	Mutation rewiring degron network	0.2222
p.Q127K	DO47573	SKCM	ICGC	LEPFKE	LIG_APCC_ABBA_1	131:136	Mutation rewiring degron network	0.2222
p.M137I	TCGA-DU-6392	LGG	TCGA	LEPFKE	LIG_APCC_ABBA_1	131:136	Mutation rewiring degron network	0.3056
p.M137I	DO22237	LGG	ICGC	LEPFKE	LIG_APCC_ABBA_1	131:136	Mutation rewiring degron network	0.3056
p.E128K	TCGA-EE-A29Q	SKCM	TCGA	LEPFKE	LIG_APCC_ABBA_1	131:136	Mutation rewiring degron network	0.25
p.E128K	DO37866	SKCM	ICGC	LEPFKE	LIG_APCC_ABBA_1	131:136	Mutation rewiring degron network	0.25
p.L138M	TCGA-EO-A22U	UCEC	TCGA	LEPFKE	LIG_APCC_ABBA_1	131:136	Mutation rewiring degron network	0.2778
p.L138M	DO43755	UCEC	ICGC	LEPFKE	LIG_APCC_ABBA_1	131:136	Mutation rewiring degron network	0.2778
p.E128D	TCGA-FS-A1ZR	SKCM	TCGA	LEPFKE	LIG_APCC_ABBA_1	131:136	Mutation rewiring degron network	0.25
p.E128D	DO37651	SKCM	ICGC	LEPFKE	LIG_APCC_ABBA_1	131:136	Mutation rewiring degron network	0.25
p.T409I	TCGA-YD-A89C	SKCM	TCGA	ISGTPELS	DEG_SCF_FBW7_1	406:413	Mutation altering degron motif	0.7078
p.T409I	DO219501	SKCM	ICGC	ISGTPELS	DEG_SCF_FBW7_1	406:413	Mutation altering degron motif	0.7078
p.S407L	TCGA-ZF-A9RC	BLCA	TCGA	ISGTPELS	DEG_SCF_FBW7_1	406:413	Mutation altering degron motif	0.6556
p.S407L	DO219068	BLCA	ICGC	ISGTPELS	DEG_SCF_FBW7_1	406:413	Mutation altering degron motif	0.6556
p.M137T	DO229005	COCA	ICGC	LEPFKE	LIG_APCC_ABBA_1	131:136	Mutation rewiring degron network	0.3056
p.M137T	DO231007	LUSC	ICGC	LEPFKE	LIG_APCC_ABBA_1	131:136	Mutation rewiring degron network	0.3056
p.Q421K	DO233749	GACA	ICGC	ISGTPELS	DEG_SCF_FBW7_1	406:413	Mutation rewiring degron network	0.1111
p.A129S	DO229041	LICA	ICGC	LEPFKE	LIG_APCC_ABBA_1	131:136	Mutation rewiring degron network	0.2778
p.I422T	SIDM00608	Plasma Cell Myeloma	GDSC	ISGTPELS	DEG_SCF_FBW7_1	406:413	Mutation rewiring degron network	0.0833
p.I422T	ACH-000714	Myeloma	CCLE	ISGTPELS	DEG_SCF_FBW7_1	406:413	Mutation rewiring degron network	0.0833
p.I422T	KMS-11	haematopoietic and lymphoid tissue	COSMIC	ISGTPELS	DEG_SCF_FBW7_1	406:413	Mutation rewiring degron network	0.0833
p.A141T	SIDM00946	T-Lymphoblastic Leukemia	GDSC	LEPFKE	LIG_APCC_ABBA_1	131:136	Mutation rewiring degron network	0.1944
p.A141T	ACH-000981	Leukemia	CCLE	LEPFKE	LIG_APCC_ABBA_1	131:136	Mutation rewiring degron network	0.1944
p.A141T	DND-41	haematopoietic and lymphoid tissue	COSMIC	LEPFKE	LIG_APCC_ABBA_1	131:136	Mutation rewiring degron network	0.1944
p.S135N	DND-41	haematopoietic and lymphoid tissue	COSMIC	LEPFKE	LIG_APCC_ABBA_1	131:136	Mutation altering degron motif	0.7069
p.T122K	NCI-H1573	lung	COSMIC	LEPFKE	LIG_APCC_ABBA_1	131:136	Mutation rewiring degron network	0.0833

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SH2D7

UniProt ID: A6NKC9

Entrez ID: 646892

Protein name: SH2 domain-containing protein 7

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SH2D7 in