DegronMD

Uniprot ID: A6NKC9

Source protein: SH2 domain-containing protein 7

Source gene: SH2D7

Class: LIG_APCC_ABBA_1

Location: 131:136

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9681

ASA_SCORE: 73.7667

COIL: 0.7507

CONS_SCORE: 0.3606

DSS_SCORE: 0.3541

HELIX: 0.1075

FCONS_SCORE: 0.9689

RIG_SCORE: 0.7977

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P133H	TCGA-38-4632	LUAD	TCGA	LEPFKE	LIG_APCC_ABBA_1	0.7694
p.P133H	DO23858	LUAD	ICGC	LEPFKE	LIG_APCC_ABBA_1	0.7694
p.Q127K	TCGA-D3-A1QB	SKCM	TCGA	LEPFKE	LIG_APCC_ABBA_1	0.2222
p.Q127K	DO47573	SKCM	ICGC	LEPFKE	LIG_APCC_ABBA_1	0.2222
p.M137I	TCGA-DU-6392	LGG	TCGA	LEPFKE	LIG_APCC_ABBA_1	0.3056
p.M137I	DO22237	LGG	ICGC	LEPFKE	LIG_APCC_ABBA_1	0.3056
p.E128K	TCGA-EE-A29Q	SKCM	TCGA	LEPFKE	LIG_APCC_ABBA_1	0.25
p.E128K	DO37866	SKCM	ICGC	LEPFKE	LIG_APCC_ABBA_1	0.25
p.L138M	TCGA-EO-A22U	UCEC	TCGA	LEPFKE	LIG_APCC_ABBA_1	0.2778
p.L138M	DO43755	UCEC	ICGC	LEPFKE	LIG_APCC_ABBA_1	0.2778
p.E128D	TCGA-FS-A1ZR	SKCM	TCGA	LEPFKE	LIG_APCC_ABBA_1	0.25
p.E128D	DO37651	SKCM	ICGC	LEPFKE	LIG_APCC_ABBA_1	0.25
p.M137T	DO229005	COCA	ICGC	LEPFKE	LIG_APCC_ABBA_1	0.3056
p.M137T	DO231007	LUSC	ICGC	LEPFKE	LIG_APCC_ABBA_1	0.3056
p.A129S	DO229041	LICA	ICGC	LEPFKE	LIG_APCC_ABBA_1	0.2778
p.A141T	SIDM00946	T-Lymphoblastic Leukemia	GDSC	LEPFKE	LIG_APCC_ABBA_1	0.1944
p.A141T	ACH-000981	Leukemia	CCLE	LEPFKE	LIG_APCC_ABBA_1	0.1944
p.A141T	DND-41	haematopoietic_and_lymphoid_tissue	COSMIC	LEPFKE	LIG_APCC_ABBA_1	0.1944
p.S135N	DND-41	haematopoietic_and_lymphoid_tissue	COSMIC	LEPFKE	LIG_APCC_ABBA_1	0.7069
p.T122K	NCI-H1573	lung	COSMIC	LEPFKE	LIG_APCC_ABBA_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A6NKC9	SH2 domain-containing protein 7	LIG_APCC_ABBA_1	131:136	LEPFKE	APC,CDC20,FZR1	0.9681	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons