DegronMD

Uniprot ID: Q2TAP0

Source protein: Golgin subfamily A member 7B

Source gene: GOLGA7B

Class: LIG_APCC_ABBA_1

Location: 134:139

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.755

ASA_SCORE: 38.0833

COIL: 0.298

CONS_SCORE: 0.4996

DSS_SCORE: 0.4017

HELIX: 0.0075

FCONS_SCORE: 1.0458

RIG_SCORE: 0.8696

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E133Q	TCGA-IR-A3LK	CESC	TCGA	ISIYED	LIG_APCC_ABBA_1	0.3056
p.E133Q	DO44299	CESC	ICGC	ISIYED	LIG_APCC_ABBA_1	0.3056
p.R140Q	DO233619	GACA	ICGC	ISIYED	LIG_APCC_ABBA_1	0.3056
p.E138D	DO229019	LICA	ICGC	ISIYED	LIG_APCC_ABBA_1	0.5647
p.L128I	DO52667	MALY	ICGC	ISIYED	LIG_APCC_ABBA_1	0.1667
p.I136V	ACH-000962	Ovarian Cancer	CCLE	ISIYED	LIG_APCC_ABBA_1	0.5965
p.I136V	ACH-001145	Ovarian Cancer	CCLE	ISIYED	LIG_APCC_ABBA_1	0.5965
p.I136V	OC-314	ovary	COSMIC	ISIYED	LIG_APCC_ABBA_1	0.5965
p.G144D	ACH-000989	Colon/Colorectal Cancer	CCLE	ISIYED	LIG_APCC_ABBA_1	0.1944
p.I135V	OC-314	ovary	COSMIC	ISIYED	LIG_APCC_ABBA_1	0.7076

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q2TAP0	Golgin subfamily A member 7B	LIG_APCC_ABBA_1	134:139	ISIYED	APC,CDC20,FZR1	0.755	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons