DegronMD

Uniprot ID: Q9BT88

Source protein: Synaptotagmin-11

Source gene: SYT11

Class: LIG_APCC_ABBA_1

Location: 62:67

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8112

ASA_SCORE: 75.55

COIL: 0.689

CONS_SCORE: 0.5138

DSS_SCORE: 0.2508

HELIX: 0.1503

FCONS_SCORE: 0.8748

RIG_SCORE: 0.7946

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T68N	TCGA-61-1915	OV	TCGA	ISIYPE	LIG_APCC_ABBA_1	0.3056
p.T68N	DO31100	OV	ICGC	ISIYPE	LIG_APCC_ABBA_1	0.3056
p.F55C	TCGA-AA-3984	COAD	TCGA	ISIYPE	LIG_APCC_ABBA_1	0.1389
p.F55C	DO9002	COAD	ICGC	ISIYPE	LIG_APCC_ABBA_1	0.1389
p.H57R	TCGA-B5-A3FA	UCEC	TCGA	ISIYPE	LIG_APCC_ABBA_1	0.1944
p.H57R	DO52402	UCEC	ICGC	ISIYPE	LIG_APCC_ABBA_1	0.1944
p.I64T	TCGA-CR-7370	HNSC	TCGA	ISIYPE	LIG_APCC_ABBA_1	0.7078
p.I64T	DO14426	HNSC	ICGC	ISIYPE	LIG_APCC_ABBA_1	0.7078
p.L69F	TCGA-D3-A8GK	SKCM	TCGA	ISIYPE	LIG_APCC_ABBA_1	0.2778
p.L69F	DO50286	SKCM	ICGC	ISIYPE	LIG_APCC_ABBA_1	0.2778
p.F55V	TCGA-EO-A22U	UCEC	TCGA	ISIYPE	LIG_APCC_ABBA_1	0.1389
p.F55V	DO43755	UCEC	ICGC	ISIYPE	LIG_APCC_ABBA_1	0.1389
p.I76M	DO48459	BLCA	ICGC	ISIYPE	LIG_APCC_ABBA_1	0.0833
p.D76N	DO233869	GACA	ICGC	ISIYPE	LIG_APCC_ABBA_1	0.0833
p.D76E	DO25396	LUAD	ICGC	ISIYPE	LIG_APCC_ABBA_1	0.0833
p.S69N	DO41253	UCEC	ICGC	ISIYPE	LIG_APCC_ABBA_1	0.2778
p.P66Q	SIDM00715	Non-Small Cell Lung Carcinoma	GDSC	ISIYPE	LIG_APCC_ABBA_1	0.5924
p.P66Q	ACH-000521	Lung Cancer	CCLE	ISIYPE	LIG_APCC_ABBA_1	0.5924
p.P66Q	NCI-H2030	lung	COSMIC	ISIYPE	LIG_APCC_ABBA_1	0.5924
p.N71H	SIDM00861	Ovarian Carcinoma	GDSC	ISIYPE	LIG_APCC_ABBA_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9BT88	Synaptotagmin-11	LIG_APCC_ABBA_1	62:67	ISIYPE	APC,CDC20,FZR1	0.8112	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons