DegronMD - Q9BT88(SYT11)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S138C	TCGA-29-1699	OV	TCGA	LTPGES	DEG_SCF_FBW7_1	139:144	Mutation rewiring degron network	0.3056
p.S138C	DO32347	OV	ICGC	LTPGES	DEG_SCF_FBW7_1	139:144	Mutation rewiring degron network	0.3056
p.E154D	TCGA-49-AARO	LUAD	TCGA	LTPGES	DEG_SCF_FBW7_1	139:144	Mutation rewiring degron network	0.0556
p.E154D	DO218924	LUAD	ICGC	LTPGES	DEG_SCF_FBW7_1	139:144	Mutation rewiring degron network	0.0556
p.E154D	SIDM02041	Colorectal Carcinoma	GDSC	LTPGES	DEG_SCF_FBW7_1	139:144	Mutation rewiring degron network	0.0556
p.T68N	TCGA-61-1915	OV	TCGA	ISIYPE	LIG_APCC_ABBA_1	62:67	Mutation rewiring degron network	0.3056
p.T68N	DO31100	OV	ICGC	ISIYPE	LIG_APCC_ABBA_1	62:67	Mutation rewiring degron network	0.3056
p.S144I	TCGA-62-A46O	LUAD	TCGA	LTPGES	DEG_SCF_FBW7_1	139:144	Mutation altering degron motif	0.7341
p.S144I	DO26240	LUAD	ICGC	LTPGES	DEG_SCF_FBW7_1	139:144	Mutation altering degron motif	0.7341
p.S148T	TCGA-66-2785	LUSC	TCGA	LTPGES	DEG_SCF_FBW7_1	139:144	Mutation rewiring degron network	0.2222
p.S148T	DO26520	LUSC	ICGC	LTPGES	DEG_SCF_FBW7_1	139:144	Mutation rewiring degron network	0.2222
p.S144G	TCGA-77-8136	LUSC	TCGA	LTPGES	DEG_SCF_FBW7_1	139:144	Mutation altering degron motif	0.6993
p.S144G	DO26593	LUSC	ICGC	LTPGES	DEG_SCF_FBW7_1	139:144	Mutation altering degron motif	0.6993
p.F55C	TCGA-AA-3984	COAD	TCGA	ISIYPE	LIG_APCC_ABBA_1	62:67	Mutation rewiring degron network	0.1389
p.F55C	DO9002	COAD	ICGC	ISIYPE	LIG_APCC_ABBA_1	62:67	Mutation rewiring degron network	0.1389
p.G142V	TCGA-AX-A063	UCEC	TCGA	LTPGES	DEG_SCF_FBW7_1	139:144	Mutation altering degron motif	0.6421
p.G142V	DO42201	UCEC	ICGC	LTPGES	DEG_SCF_FBW7_1	139:144	Mutation altering degron motif	0.6421
p.H57R	TCGA-B5-A3FA	UCEC	TCGA	ISIYPE	LIG_APCC_ABBA_1	62:67	Mutation rewiring degron network	0.1944
p.H57R	DO52402	UCEC	ICGC	ISIYPE	LIG_APCC_ABBA_1	62:67	Mutation rewiring degron network	0.1944
p.I64T	TCGA-CR-7370	HNSC	TCGA	ISIYPE	LIG_APCC_ABBA_1	62:67	Mutation altering degron motif	0.7078
p.I64T	DO14426	HNSC	ICGC	ISIYPE	LIG_APCC_ABBA_1	62:67	Mutation altering degron motif	0.7078
p.L69F	TCGA-D3-A8GK	SKCM	TCGA	ISIYPE	LIG_APCC_ABBA_1	62:67	Mutation rewiring degron network	0.2778
p.L69F	DO50286	SKCM	ICGC	ISIYPE	LIG_APCC_ABBA_1	62:67	Mutation rewiring degron network	0.2778
p.F55V	TCGA-EO-A22U	UCEC	TCGA	ISIYPE	LIG_APCC_ABBA_1	62:67	Mutation rewiring degron network	0.1389
p.F55V	DO43755	UCEC	ICGC	ISIYPE	LIG_APCC_ABBA_1	62:67	Mutation rewiring degron network	0.1389
p.S148F	TCGA-EW-A1J5	BRCA	TCGA	LTPGES	DEG_SCF_FBW7_1	139:144	Mutation rewiring degron network	0.2222
p.S148F	DO6144	BRCA	ICGC	LTPGES	DEG_SCF_FBW7_1	139:144	Mutation rewiring degron network	0.2222
p.E153Q	TCGA-G2-A2ES	BLCA	TCGA	LTPGES	DEG_SCF_FBW7_1	139:144	Mutation rewiring degron network	0.0833
p.E153Q	DO785	BLCA	ICGC	LTPGES	DEG_SCF_FBW7_1	139:144	Mutation rewiring degron network	0.0833
p.E131D	TCGA-HU-A4GH	STAD	TCGA	LTPGES	DEG_SCF_FBW7_1	139:144	Mutation rewiring degron network	0.1111
p.E131D	DO47743	STAD	ICGC	LTPGES	DEG_SCF_FBW7_1	139:144	Mutation rewiring degron network	0.1111
p.I76M	DO48459	BLCA	ICGC	ISIYPE	LIG_APCC_ABBA_1	62:67	Mutation rewiring degron network	0.0833
p.E153A	DO230315	COCA	ICGC	LTPGES	DEG_SCF_FBW7_1	139:144	Mutation rewiring degron network	0.0833
p.D76N	DO233869	GACA	ICGC	ISIYPE	LIG_APCC_ABBA_1	62:67	Mutation rewiring degron network	0.0833
p.T146I	DO50970	LICA	ICGC	LTPGES	DEG_SCF_FBW7_1	139:144	Mutation rewiring degron network	0.2778
p.T146I	DO218861	SKCA	ICGC	LTPGES	DEG_SCF_FBW7_1	139:144	Mutation rewiring degron network	0.2778
p.D76E	DO25396	LUAD	ICGC	ISIYPE	LIG_APCC_ABBA_1	62:67	Mutation rewiring degron network	0.0833
p.S69N	DO41253	UCEC	ICGC	ISIYPE	LIG_APCC_ABBA_1	62:67	Mutation rewiring degron network	0.2778
p.P66Q	SIDM00715	Non-Small Cell Lung Carcinoma	GDSC	ISIYPE	LIG_APCC_ABBA_1	62:67	Mutation altering degron motif	0.5924
p.P66Q	ACH-000521	Lung Cancer	CCLE	ISIYPE	LIG_APCC_ABBA_1	62:67	Mutation altering degron motif	0.5924
p.P66Q	NCI-H2030	lung	COSMIC	ISIYPE	LIG_APCC_ABBA_1	62:67	Mutation altering degron motif	0.5924
p.N71H	SIDM00861	Ovarian Carcinoma	GDSC	ISIYPE	LIG_APCC_ABBA_1	62:67	Mutation rewiring degron network	0.2222
p.E143K	SIDM00015	Esophageal Squamous Cell Carcinoma	GDSC	LTPGES	DEG_SCF_FBW7_1	139:144	Mutation altering degron motif	0.591
p.E143K	ACH-000777	Esophageal Cancer	CCLE	LTPGES	DEG_SCF_FBW7_1	139:144	Mutation altering degron motif	0.591

Kaplan plot for SYT11 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SYT11

UniProt ID: Q9BT88

Entrez ID: 23208

Protein name: Synaptotagmin-11 (Synaptotagmin XI) (SytXI)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SYT11 in