DegronMD

Uniprot ID: Q9BT88

Source protein: Synaptotagmin-11

Source gene: SYT11

Class: DEG_SCF_FBW7_1

Location: 139:144

E3 ligase: FBXW7

DEGRON score: 0.9988

ASA_SCORE: 80.4333

COIL: 0.934

CONS_SCORE: 0.6037

DSS_SCORE: 0.6969

HELIX: 0.0403

FCONS_SCORE: 1.2215

RIG_SCORE: 0.6021

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S138C	TCGA-29-1699	OV	TCGA	LTPGES	DEG_SCF_FBW7_1	0.3056
p.S138C	DO32347	OV	ICGC	LTPGES	DEG_SCF_FBW7_1	0.3056
p.E154D	TCGA-49-AARO	LUAD	TCGA	LTPGES	DEG_SCF_FBW7_1	0.0556
p.E154D	DO218924	LUAD	ICGC	LTPGES	DEG_SCF_FBW7_1	0.0556
p.E154D	SIDM02041	Colorectal Carcinoma	GDSC	LTPGES	DEG_SCF_FBW7_1	0.0556
p.S144I	TCGA-62-A46O	LUAD	TCGA	LTPGES	DEG_SCF_FBW7_1	0.7341
p.S144I	DO26240	LUAD	ICGC	LTPGES	DEG_SCF_FBW7_1	0.7341
p.S148T	TCGA-66-2785	LUSC	TCGA	LTPGES	DEG_SCF_FBW7_1	0.2222
p.S148T	DO26520	LUSC	ICGC	LTPGES	DEG_SCF_FBW7_1	0.2222
p.S144G	TCGA-77-8136	LUSC	TCGA	LTPGES	DEG_SCF_FBW7_1	0.6993
p.S144G	DO26593	LUSC	ICGC	LTPGES	DEG_SCF_FBW7_1	0.6993
p.G142V	TCGA-AX-A063	UCEC	TCGA	LTPGES	DEG_SCF_FBW7_1	0.6421
p.G142V	DO42201	UCEC	ICGC	LTPGES	DEG_SCF_FBW7_1	0.6421
p.S148F	TCGA-EW-A1J5	BRCA	TCGA	LTPGES	DEG_SCF_FBW7_1	0.2222
p.S148F	DO6144	BRCA	ICGC	LTPGES	DEG_SCF_FBW7_1	0.2222
p.E153Q	TCGA-G2-A2ES	BLCA	TCGA	LTPGES	DEG_SCF_FBW7_1	0.0833
p.E153Q	DO785	BLCA	ICGC	LTPGES	DEG_SCF_FBW7_1	0.0833
p.E131D	TCGA-HU-A4GH	STAD	TCGA	LTPGES	DEG_SCF_FBW7_1	0.1111
p.E131D	DO47743	STAD	ICGC	LTPGES	DEG_SCF_FBW7_1	0.1111
p.E153A	DO230315	COCA	ICGC	LTPGES	DEG_SCF_FBW7_1	0.0833
p.T146I	DO50970	LICA	ICGC	LTPGES	DEG_SCF_FBW7_1	0.2778
p.T146I	DO218861	SKCA	ICGC	LTPGES	DEG_SCF_FBW7_1	0.2778
p.E143K	SIDM00015	Esophageal Squamous Cell Carcinoma	GDSC	LTPGES	DEG_SCF_FBW7_1	0.591
p.E143K	ACH-000777	Esophageal Cancer	CCLE	LTPGES	DEG_SCF_FBW7_1	0.591

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9BT88	Synaptotagmin-11	DEG_SCF_FBW7_1	139:144	LTPGES	FBXW7	0.9988	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons