DegronMD

Uniprot ID: Q14435

Source protein: Polypeptide N-acetylgalactosaminyltransferase 3

Source gene: GALNT3

Class: LIG_APCC_ABBA_1

Location: 158:163

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9679

ASA_SCORE: 63.3833

COIL: 0.744

CONS_SCORE: 0.6392

DSS_SCORE: 0.4866

HELIX: 0.0937

FCONS_SCORE: 1.0222

RIG_SCORE: 0.7071

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A154T	TCGA-21-1080	LUSC	TCGA	ISLHRD	LIG_APCC_ABBA_1	0.2222
p.A154T	DO26502	LUSC	ICGC	ISLHRD	LIG_APCC_ABBA_1	0.2222
p.D163H	TCGA-2F-A9KR	BLCA	TCGA	ISLHRD	LIG_APCC_ABBA_1	0.7688
p.D163H	DO51862	BLCA	ICGC	ISLHRD	LIG_APCC_ABBA_1	0.7688
p.N151I	TCGA-EE-A3JI	SKCM	TCGA	ISLHRD	LIG_APCC_ABBA_1	0.1389
p.N151I	DO47268	SKCM	ICGC	ISLHRD	LIG_APCC_ABBA_1	0.1389
p.R169Q	TCGA-G4-6586	COAD	TCGA	ISLHRD	LIG_APCC_ABBA_1	0.1667
p.R169Q	DO9698	COAD	ICGC	ISLHRD	LIG_APCC_ABBA_1	0.1667
p.H148N	DO229015	LICA	ICGC	ISLHRD	LIG_APCC_ABBA_1	0.0556
p.P166Q	DO229026	LICA	ICGC	ISLHRD	LIG_APCC_ABBA_1	0.25
p.P166T	DO229036	LICA	ICGC	ISLHRD	LIG_APCC_ABBA_1	0.25
p.C173R	DO219878	SKCA	ICGC	ISLHRD	LIG_APCC_ABBA_1	0.0556
p.R156H	SNU-407	large_intestine	COSMIC	ISLHRD	LIG_APCC_ABBA_1	0.2778
p.R156H	CHSA0011	bone	COSMIC	ISLHRD	LIG_APCC_ABBA_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q14435	Polypeptide N-acetylgalactosaminyltransferase 3	LIG_APCC_ABBA_1	158:163	ISLHRD	APC,CDC20,FZR1	0.9679	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons