DegronMD - Q14435(GALNT3)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A154T	TCGA-21-1080	LUSC	TCGA	ISLHRD	LIG_APCC_ABBA_1	158:163	Mutation rewiring degron network	0.2222
p.A154T	TCGA-21-1080	LUSC	TCGA	RISLHRD	LIG_APCC_ABBAyCdc20_2	157:163	Mutation rewiring degron network	0.25
p.A154T	DO26502	LUSC	ICGC	ISLHRD	LIG_APCC_ABBA_1	158:163	Mutation rewiring degron network	0.2222
p.A154T	DO26502	LUSC	ICGC	RISLHRD	LIG_APCC_ABBAyCdc20_2	157:163	Mutation rewiring degron network	0.25
p.D163H	TCGA-2F-A9KR	BLCA	TCGA	ISLHRD	LIG_APCC_ABBA_1	158:163	Mutation altering degron motif	0.7688
p.D163H	TCGA-2F-A9KR	BLCA	TCGA	RISLHRD	LIG_APCC_ABBAyCdc20_2	157:163	Mutation altering degron motif	0.7688
p.D163H	DO51862	BLCA	ICGC	ISLHRD	LIG_APCC_ABBA_1	158:163	Mutation altering degron motif	0.7688
p.D163H	DO51862	BLCA	ICGC	RISLHRD	LIG_APCC_ABBAyCdc20_2	157:163	Mutation altering degron motif	0.7688
p.N151I	TCGA-EE-A3JI	SKCM	TCGA	ISLHRD	LIG_APCC_ABBA_1	158:163	Mutation rewiring degron network	0.1389
p.N151I	TCGA-EE-A3JI	SKCM	TCGA	RISLHRD	LIG_APCC_ABBAyCdc20_2	157:163	Mutation rewiring degron network	0.1667
p.N151I	DO47268	SKCM	ICGC	ISLHRD	LIG_APCC_ABBA_1	158:163	Mutation rewiring degron network	0.1389
p.N151I	DO47268	SKCM	ICGC	RISLHRD	LIG_APCC_ABBAyCdc20_2	157:163	Mutation rewiring degron network	0.1667
p.R169Q	TCGA-G4-6586	COAD	TCGA	ISLHRD	LIG_APCC_ABBA_1	158:163	Mutation rewiring degron network	0.1667
p.R169Q	TCGA-G4-6586	COAD	TCGA	RISLHRD	LIG_APCC_ABBAyCdc20_2	157:163	Mutation rewiring degron network	0.1667
p.R169Q	DO9698	COAD	ICGC	ISLHRD	LIG_APCC_ABBA_1	158:163	Mutation rewiring degron network	0.1667
p.R169Q	DO9698	COAD	ICGC	RISLHRD	LIG_APCC_ABBAyCdc20_2	157:163	Mutation rewiring degron network	0.1667
p.H148N	DO229015	LICA	ICGC	ISLHRD	LIG_APCC_ABBA_1	158:163	Mutation rewiring degron network	0.0556
p.H148N	DO229015	LICA	ICGC	RISLHRD	LIG_APCC_ABBAyCdc20_2	157:163	Mutation rewiring degron network	0.0833
p.P166Q	DO229026	LICA	ICGC	ISLHRD	LIG_APCC_ABBA_1	158:163	Mutation rewiring degron network	0.25
p.P166Q	DO229026	LICA	ICGC	RISLHRD	LIG_APCC_ABBAyCdc20_2	157:163	Mutation rewiring degron network	0.25
p.P166T	DO229036	LICA	ICGC	ISLHRD	LIG_APCC_ABBA_1	158:163	Mutation rewiring degron network	0.25
p.P166T	DO229036	LICA	ICGC	RISLHRD	LIG_APCC_ABBAyCdc20_2	157:163	Mutation rewiring degron network	0.25
p.C173R	DO219878	SKCA	ICGC	ISLHRD	LIG_APCC_ABBA_1	158:163	Mutation rewiring degron network	0.0556
p.C173R	DO219878	SKCA	ICGC	RISLHRD	LIG_APCC_ABBAyCdc20_2	157:163	Mutation rewiring degron network	0.0556
p.R156H	SNU-407	large intestine	COSMIC	ISLHRD	LIG_APCC_ABBA_1	158:163	Mutation rewiring degron network	0.2778
p.R156H	SNU-407	large intestine	COSMIC	RISLHRD	LIG_APCC_ABBAyCdc20_2	157:163	Mutation rewiring degron network	0.3056
p.R156H	CHSA0011	bone	COSMIC	ISLHRD	LIG_APCC_ABBA_1	158:163	Mutation rewiring degron network	0.2778
p.R156H	CHSA0011	bone	COSMIC	RISLHRD	LIG_APCC_ABBAyCdc20_2	157:163	Mutation rewiring degron network	0.3056

Kaplan plot for GALNT3 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

GALNT3

UniProt ID: Q14435

Entrez ID: 2591

Protein name: Polypeptide N-acetylgalactosaminyltransferase 3 (EC 2.4.1.41) (Polypeptide GalNAc transferase 3) (GalNAc-T3) (pp-GaNTase 3) (Protein-UDP acetylgalactosaminyltransferase 3) (UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 3)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for GALNT3 in