DegronMD

Uniprot ID: Q14435

Source protein: Polypeptide N-acetylgalactosaminyltransferase 3

Source gene: GALNT3

Class: LIG_APCC_ABBAyCdc20_2

Location: 157:163

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9925

ASA_SCORE: 68.3286

COIL: 0.7317

CONS_SCORE: 0.6463

DSS_SCORE: 0.4726

HELIX: 0.1249

FCONS_SCORE: 1.0509

RIG_SCORE: 0.7111

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A154T	TCGA-21-1080	LUSC	TCGA	RISLHRD	LIG_APCC_ABBAyCdc20_2	0.25
p.A154T	DO26502	LUSC	ICGC	RISLHRD	LIG_APCC_ABBAyCdc20_2	0.25
p.D163H	TCGA-2F-A9KR	BLCA	TCGA	RISLHRD	LIG_APCC_ABBAyCdc20_2	0.7688
p.D163H	DO51862	BLCA	ICGC	RISLHRD	LIG_APCC_ABBAyCdc20_2	0.7688
p.N151I	TCGA-EE-A3JI	SKCM	TCGA	RISLHRD	LIG_APCC_ABBAyCdc20_2	0.1667
p.N151I	DO47268	SKCM	ICGC	RISLHRD	LIG_APCC_ABBAyCdc20_2	0.1667
p.R169Q	TCGA-G4-6586	COAD	TCGA	RISLHRD	LIG_APCC_ABBAyCdc20_2	0.1667
p.R169Q	DO9698	COAD	ICGC	RISLHRD	LIG_APCC_ABBAyCdc20_2	0.1667
p.H148N	DO229015	LICA	ICGC	RISLHRD	LIG_APCC_ABBAyCdc20_2	0.0833
p.P166Q	DO229026	LICA	ICGC	RISLHRD	LIG_APCC_ABBAyCdc20_2	0.25
p.P166T	DO229036	LICA	ICGC	RISLHRD	LIG_APCC_ABBAyCdc20_2	0.25
p.C173R	DO219878	SKCA	ICGC	RISLHRD	LIG_APCC_ABBAyCdc20_2	0.0556
p.R156H	SNU-407	large_intestine	COSMIC	RISLHRD	LIG_APCC_ABBAyCdc20_2	0.3056
p.R156H	CHSA0011	bone	COSMIC	RISLHRD	LIG_APCC_ABBAyCdc20_2	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q14435	Polypeptide N-acetylgalactosaminyltransferase 3	LIG_APCC_ABBAyCdc20_2	157:163	RISLHRD	APC,CDC20,FZR1	0.9925	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons