DegronMD

Uniprot ID: Q9BZS1

Source protein: Forkhead box protein P3

Source gene: FOXP3

Class: DEG_SCF_FBW7_1

Location: 129:136

E3 ligase: FBXW7

DEGRON score: 0.9974

ASA_SCORE: 81.6625

COIL: 0.8948

CONS_SCORE: 0.6568

DSS_SCORE: 0.4079

HELIX: 0.0507

FCONS_SCORE: 0.9991

RIG_SCORE: 0.7115

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S125I	TCGA-06-1801	GBM	TCGA	ISLTPPTT	DEG_SCF_FBW7_1	0.2222
p.R146Q	TCGA-B5-A3FA	UCEC	TCGA	ISLTPPTT	DEG_SCF_FBW7_1	0.0556
p.R146W	TCGA-FR-A726	SKCM	TCGA	ISLTPPTT	DEG_SCF_FBW7_1	0.0556
p.A141E	DO229006	LICA	ICGC	ISLTPPTT	DEG_SCF_FBW7_1	0.1944
p.R143K	DO37436	SKCM	ICGC	ISLTPPTT	DEG_SCF_FBW7_1	0.1389
p.P142H	HT-29	large_intestine	COSMIC	ISLTPPTT	DEG_SCF_FBW7_1	0.6111
p.P127H	HT-29	large_intestine	COSMIC	ISLTPPTT	DEG_SCF_FBW7_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9BZS1	Forkhead box protein P3	DEG_SCF_FBW7_1	129:136	ISLTPPTT	FBXW7	0.9974	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons