DegronMD

Uniprot ID: P11498

Source protein: Pyruvate carboxylase, mitochondrial

Source gene: PC

Class: LIG_APCC_ABBA_1

Location: 418:423

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8524

ASA_SCORE: 28.2333

COIL: 0.8257

CONS_SCORE: 0.4864

DSS_SCORE: 0.1188

HELIX: 0.038

FCONS_SCORE: 1.2733

RIG_SCORE: 0.7976

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S424P	TCGA-AP-A059	UCEC	TCGA	ISPHYD	LIG_APCC_ABBA_1	0.3056
p.D408Y	TCGA-D3-A8GB	SKCM	TCGA	ISPHYD	LIG_APCC_ABBA_1	0.0556
p.R413Q	DO47537	SKCM	ICGC	ISPHYD	LIG_APCC_ABBA_1	0.1944
p.G414C	DO40801	UCEC	ICGC	ISPHYD	LIG_APCC_ABBA_1	0.2222
p.A412T	SIDM01307	Colorectal Carcinoma	GDSC	ISPHYD	LIG_APCC_ABBA_1	0.1667
p.G433D	SIDM01609	Endometrial Carcinoma	GDSC	ISPHYD	LIG_APCC_ABBA_1	0.0556
p.G433D	ACH-000972	Endometrial/Uterine Cancer	CCLE	ISPHYD	LIG_APCC_ABBA_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P11498	Pyruvate carboxylase, mitochondrial	LIG_APCC_ABBA_1	418:423	ISPHYD	APC,CDC20,FZR1	0.8524	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons