DegronMD

Uniprot ID: Q96QE3

Source protein: ATPase family AAA domain-containing protein 5

Source gene: ATAD5

Class: DEG_SCF_FBW7_2

Location: 600:607

E3 ligase: FBXW7

DEGRON score: 0.7822

ASA_SCORE: 95.525

COIL: 0.9064

CONS_SCORE: 0.2855

DSS_SCORE: 0.6263

HELIX: 0.0533

FCONS_SCORE: 0.9318

RIG_SCORE: 0.6383

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S614C	TCGA-CR-7391	HNSC	TCGA	ISSTPTTE	DEG_SCF_FBW7_2	0.5833
p.S614C	DO15198	HNSC	ICGC	ISSTPTTE	DEG_SCF_FBW7_2	0.5833
p.R596I	DO229028	LICA	ICGC	ISSTPTTE	DEG_SCF_FBW7_2	0.2222
p.R596T	ACH-001673	Bile Duct Cancer	CCLE	ISSTPTTE	DEG_SCF_FBW7_2	0.2222
p.E607Q	ACH-001673	Bile Duct Cancer	CCLE	ISSTPTTE	DEG_SCF_FBW7_2	0.6744

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96QE3	ATPase family AAA domain-containing protein 5	DEG_SCF_FBW7_2	600:607	ISSTPTTE	FBXW7	0.7822	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons