DegronMD - Q96QE3(ATAD5)

FUNCTION: Involved in DNA damage response. Involved in a RAD9A-related damage checkpoint, a pathway that is important in determining whether DNA damage is compatible with cell survival or whether it requires cell elimination by apoptosis. Modulates the RAD9A interaction with BCL2 and thereby induces DNA damages-induced apoptosis. {ECO:0000269|PubMed:15983387}.

GO - Biological processes (BP): cell population proliferation [GO:0008283]; DNA clamp unloading [GO:0090618]; intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [GO:0042771]; isotype switching [GO:0045190]; negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by ... View more >>

GO - Molecular function (MF): ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; DNA binding [GO:0003677]; DNA clamp unloader activity [GO:0061860]

GO - Cellular component (CC): Elg1 RFC-like complex [GO:0031391]; nucleus [GO:0005634]

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S1598Y	DO231120	LUSC	ICGC	VSSSS	DEG_SPOP_SBC_1	1595:1599	Mutation altering degron motif	0.712
p.E607Q	ACH-001673	Bile Duct Cancer	CCLE	ISSTPTTE	DEG_SCF_FBW7_2	600:607	Mutation altering degron motif	0.6744
p.S1596L	TCGA-TN-A7HL	HNSC	TCGA	VSSSS	DEG_SPOP_SBC_1	1595:1599	Mutation altering degron motif	0.6556
p.S1596L	DO219080	HNSC	ICGC	VSSSS	DEG_SPOP_SBC_1	1595:1599	Mutation altering degron motif	0.6556
p.H274Q	ACH-002024	Colon/Colorectal Cancer	CCLE	HKENK	DEG_APCC_KENBOX_2	274:278	Mutation altering degron motif	0.647
p.K592T	TCGA-AA-3984	COAD	TCGA	VSTPKST	DEG_SCF_FBW7_1	588:594	Mutation altering degron motif	0.6195
p.K592T	DO9002	COAD	ICGC	VSTPKST	DEG_SCF_FBW7_1	588:594	Mutation altering degron motif	0.6195
p.S614C	TCGA-CR-7391	HNSC	TCGA	ISSTPTTE	DEG_SCF_FBW7_2	600:607	Mutation blocking phosphorylation signal	0.5833
p.S614C	DO15198	HNSC	ICGC	ISSTPTTE	DEG_SCF_FBW7_2	600:607	Mutation blocking phosphorylation signal	0.5833
p.K658T	TCGA-2G-AALF	TGCT	TCGA	ISTPKKS	DEG_SCF_FBW7_1	662:668	Mutation substituting flanking lysine	0.3333
p.V279M	DO888	BOCA	ICGC	HKENK	DEG_APCC_KENBOX_2	274:278	Mutation rewiring degron network	0.3056
p.K1605N	DO8898	COAD	ICGC	VSSSS	DEG_SPOP_SBC_1	1595:1599	Mutation substituting flanking lysine	0.2778
p.K1605N	DO231120	LUSC	ICGC	VSSSS	DEG_SPOP_SBC_1	1595:1599	Mutation substituting flanking lysine	0.2778
p.K1605E	DO228420	LICA	ICGC	VSSSS	DEG_SPOP_SBC_1	1595:1599	Mutation substituting flanking lysine	0.2778
p.R596I	DO229028	LICA	ICGC	VSTPKST	DEG_SCF_FBW7_1	588:594	Mutation rewiring degron network	0.2778
p.R596T	ACH-001673	Bile Duct Cancer	CCLE	VSTPKST	DEG_SCF_FBW7_1	588:594	Mutation rewiring degron network	0.2778
p.L585F	SIDM00253	Neuroblastoma	GDSC	VSTPKST	DEG_SCF_FBW7_1	588:594	Mutation rewiring degron network	0.25
p.L585F	NB6	autonomic ganglia	COSMIC	VSTPKST	DEG_SCF_FBW7_1	588:594	Mutation rewiring degron network	0.25
p.S584I	TCGA-2G-AAM3	TGCT	TCGA	VSTPKST	DEG_SCF_FBW7_1	588:594	Mutation rewiring degron network	0.2222
p.R596I	DO229028	LICA	ICGC	ISSTPTTE	DEG_SCF_FBW7_2	600:607	Mutation rewiring degron network	0.2222

Showing 1 to 20 of 54 entries

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Kaplan plot for ATAD5 in

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

ATAD5

UniProt ID: Q96QE3

Entrez ID: 79915

Protein name: ATPase family AAA domain-containing protein 5 (Chromosome fragility-associated gene 1 protein)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ATAD5 in