DegronMD - Q96QE3(ATAD5)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.K658T	TCGA-2G-AALF	TGCT	TCGA	ISTPKKS	DEG_SCF_FBW7_1	662:668	Mutation substituting flanking lysine	0.3333
p.S584I	TCGA-2G-AAM3	TGCT	TCGA	VSTPKST	DEG_SCF_FBW7_1	588:594	Mutation rewiring degron network	0.2222
p.D1587N	TCGA-55-A4DF	LUAD	TCGA	VSSSS	DEG_SPOP_SBC_1	1595:1599	Mutation rewiring degron network	0.1111
p.D1587N	DO45318	LUAD	ICGC	VSSSS	DEG_SPOP_SBC_1	1595:1599	Mutation rewiring degron network	0.1111
p.K592T	TCGA-AA-3984	COAD	TCGA	VSTPKST	DEG_SCF_FBW7_1	588:594	Mutation altering degron motif	0.6195
p.K592T	DO9002	COAD	ICGC	VSTPKST	DEG_SCF_FBW7_1	588:594	Mutation altering degron motif	0.6195
p.S581Y	TCGA-AX-A1CE	UCEC	TCGA	VSTPKST	DEG_SCF_FBW7_1	588:594	Mutation rewiring degron network	0.1389
p.S581Y	DO42280	UCEC	ICGC	VSTPKST	DEG_SCF_FBW7_1	588:594	Mutation rewiring degron network	0.1389
p.E677K	TCGA-CR-6481	HNSC	TCGA	ISTPKKS	DEG_SCF_FBW7_1	662:668	Mutation rewiring degron network	0.0833
p.E677K	DO14990	HNSC	ICGC	ISTPKKS	DEG_SCF_FBW7_1	662:668	Mutation rewiring degron network	0.0833
p.S614C	TCGA-CR-7391	HNSC	TCGA	ISSTPTTE	DEG_SCF_FBW7_2	600:607	Mutation blocking phosphorylation signal	0.5833
p.S614C	DO15198	HNSC	ICGC	ISSTPTTE	DEG_SCF_FBW7_2	600:607	Mutation blocking phosphorylation signal	0.5833
p.S581C	TCGA-D3-A2JP	SKCM	TCGA	VSTPKST	DEG_SCF_FBW7_1	588:594	Mutation rewiring degron network	0.1389
p.S581C	DO47407	SKCM	ICGC	VSTPKST	DEG_SCF_FBW7_1	588:594	Mutation rewiring degron network	0.1389
p.E1609K	TCGA-D5-6530	COAD	TCGA	VSSSS	DEG_SPOP_SBC_1	1595:1599	Mutation rewiring degron network	0.0556
p.E1609K	DO224768	BRCA	ICGC	VSSSS	DEG_SPOP_SBC_1	1595:1599	Mutation rewiring degron network	0.0556
p.E1609K	DO8312	COAD	ICGC	VSSSS	DEG_SPOP_SBC_1	1595:1599	Mutation rewiring degron network	0.0556
p.E582K	TCGA-GC-A3I6	BLCA	TCGA	VSTPKST	DEG_SCF_FBW7_1	588:594	Mutation rewiring degron network	0.1667
p.E582K	DO844	BLCA	ICGC	VSTPKST	DEG_SCF_FBW7_1	588:594	Mutation rewiring degron network	0.1667
p.P654H	TCGA-GF-A2C7	SKCM	TCGA	ISTPKKS	DEG_SCF_FBW7_1	662:668	Mutation rewiring degron network	0.1111
p.P654H	DO37407	SKCM	ICGC	ISTPKKS	DEG_SCF_FBW7_1	662:668	Mutation rewiring degron network	0.1111
p.S1596L	TCGA-TN-A7HL	HNSC	TCGA	VSSSS	DEG_SPOP_SBC_1	1595:1599	Mutation altering degron motif	0.6556
p.S1596L	DO219080	HNSC	ICGC	VSSSS	DEG_SPOP_SBC_1	1595:1599	Mutation altering degron motif	0.6556
p.V279M	DO888	BOCA	ICGC	HKENK	DEG_APCC_KENBOX_2	274:278	Mutation rewiring degron network	0.3056
p.G1607R	DO222817	BTCA	ICGC	VSSSS	DEG_SPOP_SBC_1	1595:1599	Mutation rewiring degron network	0.1111
p.K1605N	DO8898	COAD	ICGC	VSSSS	DEG_SPOP_SBC_1	1595:1599	Mutation substituting flanking lysine	0.2778
p.K1605N	DO231120	LUSC	ICGC	VSSSS	DEG_SPOP_SBC_1	1595:1599	Mutation substituting flanking lysine	0.2778
p.K1605E	DO228420	LICA	ICGC	VSSSS	DEG_SPOP_SBC_1	1595:1599	Mutation substituting flanking lysine	0.2778
p.R596I	DO229028	LICA	ICGC	VSTPKST	DEG_SCF_FBW7_1	588:594	Mutation rewiring degron network	0.2778
p.R596I	DO229028	LICA	ICGC	ISSTPTTE	DEG_SCF_FBW7_2	600:607	Mutation rewiring degron network	0.2222
p.S1591I	DO229028	LICA	ICGC	VSSSS	DEG_SPOP_SBC_1	1595:1599	Mutation rewiring degron network	0.2222
p.S1598Y	DO231120	LUSC	ICGC	VSSSS	DEG_SPOP_SBC_1	1595:1599	Mutation altering degron motif	0.712
p.Y267H	DO228396	MALY	ICGC	HKENK	DEG_APCC_KENBOX_2	274:278	Mutation rewiring degron network	0.1389
p.S288T	SIDM00615	Hepatocellular Carcinoma	GDSC	HKENK	DEG_APCC_KENBOX_2	274:278	Mutation rewiring degron network	0.0556
p.S288T	SIDM00129	Melanoma	GDSC	HKENK	DEG_APCC_KENBOX_2	274:278	Mutation rewiring degron network	0.0556
p.S288T	SIDM01062	Breast Carcinoma	GDSC	HKENK	DEG_APCC_KENBOX_2	274:278	Mutation rewiring degron network	0.0556
p.S288T	SIDM00652	Small Cell Lung Carcinoma	GDSC	HKENK	DEG_APCC_KENBOX_2	274:278	Mutation rewiring degron network	0.0556
p.S288T	SIDM00874	Breast Carcinoma	GDSC	HKENK	DEG_APCC_KENBOX_2	274:278	Mutation rewiring degron network	0.0556
p.S288T	SIDM00049	Colorectal Carcinoma	GDSC	HKENK	DEG_APCC_KENBOX_2	274:278	Mutation rewiring degron network	0.0556
p.S288T	SIDM00732	Glioblastoma	GDSC	HKENK	DEG_APCC_KENBOX_2	274:278	Mutation rewiring degron network	0.0556
p.S288T	SIDM01727	Chronic Myelogenous Leukemia	GDSC	HKENK	DEG_APCC_KENBOX_2	274:278	Mutation rewiring degron network	0.0556
p.S288T	SIDM00015	Esophageal Squamous Cell Carcinoma	GDSC	HKENK	DEG_APCC_KENBOX_2	274:278	Mutation rewiring degron network	0.0556
p.L585F	SIDM00253	Neuroblastoma	GDSC	VSTPKST	DEG_SCF_FBW7_1	588:594	Mutation rewiring degron network	0.25
p.L585F	NB6	autonomic ganglia	COSMIC	VSTPKST	DEG_SCF_FBW7_1	588:594	Mutation rewiring degron network	0.25
p.A583V	SIDM00569	Osteosarcoma	GDSC	VSTPKST	DEG_SCF_FBW7_1	588:594	Mutation rewiring degron network	0.1944
p.A583V	ACH-002178	Bone Cancer	CCLE	VSTPKST	DEG_SCF_FBW7_1	588:594	Mutation rewiring degron network	0.1944
p.A583V	NY	bone	COSMIC	VSTPKST	DEG_SCF_FBW7_1	588:594	Mutation rewiring degron network	0.1944
p.E677Q	SIDM00688	B-Cell Non-Hodgkin's Lymphoma	GDSC	ISTPKKS	DEG_SCF_FBW7_1	662:668	Mutation rewiring degron network	0.0833
p.E677Q	ACH-002253	Lymphoma	CCLE	ISTPKKS	DEG_SCF_FBW7_1	662:668	Mutation rewiring degron network	0.0833
p.E677Q	JSC-1	haematopoietic and lymphoid tissue	COSMIC	ISTPKKS	DEG_SCF_FBW7_1	662:668	Mutation rewiring degron network	0.0833
p.R596T	ACH-001673	Bile Duct Cancer	CCLE	VSTPKST	DEG_SCF_FBW7_1	588:594	Mutation rewiring degron network	0.2778
p.R596T	ACH-001673	Bile Duct Cancer	CCLE	ISSTPTTE	DEG_SCF_FBW7_2	600:607	Mutation rewiring degron network	0.2222
p.E607Q	ACH-001673	Bile Duct Cancer	CCLE	ISSTPTTE	DEG_SCF_FBW7_2	600:607	Mutation altering degron motif	0.6744
p.H274Q	ACH-002024	Colon/Colorectal Cancer	CCLE	HKENK	DEG_APCC_KENBOX_2	274:278	Mutation altering degron motif	0.647

Kaplan plot for ATAD5 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ATAD5

UniProt ID: Q96QE3

Entrez ID: 79915

Protein name: ATPase family AAA domain-containing protein 5 (Chromosome fragility-associated gene 1 protein)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ATAD5 in