DegronMD

Uniprot ID: Q96QE3

Source protein: ATPase family AAA domain-containing protein 5

Source gene: ATAD5

Class: DEG_SCF_FBW7_1

Location: 662:668

E3 ligase: FBXW7

DEGRON score: 0.9849

ASA_SCORE: 112.0286

COIL: 0.9489

CONS_SCORE: 0.286

DSS_SCORE: 0.5947

HELIX: 0.0144

FCONS_SCORE: 0.9317

RIG_SCORE: 0.6939

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K658T	TCGA-2G-AALF	TGCT	TCGA	ISTPKKS	DEG_SCF_FBW7_1	0.3333
p.E677K	TCGA-CR-6481	HNSC	TCGA	ISTPKKS	DEG_SCF_FBW7_1	0.0833
p.E677K	DO14990	HNSC	ICGC	ISTPKKS	DEG_SCF_FBW7_1	0.0833
p.P654H	TCGA-GF-A2C7	SKCM	TCGA	ISTPKKS	DEG_SCF_FBW7_1	0.1111
p.P654H	DO37407	SKCM	ICGC	ISTPKKS	DEG_SCF_FBW7_1	0.1111
p.E677Q	SIDM00688	B-Cell Non-Hodgkin's Lymphoma	GDSC	ISTPKKS	DEG_SCF_FBW7_1	0.0833
p.E677Q	ACH-002253	Lymphoma	CCLE	ISTPKKS	DEG_SCF_FBW7_1	0.0833
p.E677Q	JSC-1	haematopoietic_and_lymphoid_tissue	COSMIC	ISTPKKS	DEG_SCF_FBW7_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96QE3	ATPase family AAA domain-containing protein 5	DEG_SCF_FBW7_1	662:668	ISTPKKS	FBXW7	0.9849	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons