DegronMD

Uniprot ID: Q96QE3

Source protein: ATPase family AAA domain-containing protein 5

Source gene: ATAD5

Class: DEG_APCC_KENBOX_2

Location: 274:278

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9122

ASA_SCORE: 116.94

COIL: 0.8122

CONS_SCORE: 0.2699

DSS_SCORE: 0.4167

HELIX: 0.174

FCONS_SCORE: 0.8265

RIG_SCORE: 0.7383

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V279M	DO888	BOCA	ICGC	HKENK	DEG_APCC_KENBOX_2	0.3056
p.Y267H	DO228396	MALY	ICGC	HKENK	DEG_APCC_KENBOX_2	0.1389
p.S288T	SIDM00615	Hepatocellular Carcinoma	GDSC	HKENK	DEG_APCC_KENBOX_2	0.0556
p.S288T	SIDM00129	Melanoma	GDSC	HKENK	DEG_APCC_KENBOX_2	0.0556
p.S288T	SIDM01062	Breast Carcinoma	GDSC	HKENK	DEG_APCC_KENBOX_2	0.0556
p.S288T	SIDM00652	Small Cell Lung Carcinoma	GDSC	HKENK	DEG_APCC_KENBOX_2	0.0556
p.S288T	SIDM00874	Breast Carcinoma	GDSC	HKENK	DEG_APCC_KENBOX_2	0.0556
p.S288T	SIDM00049	Colorectal Carcinoma	GDSC	HKENK	DEG_APCC_KENBOX_2	0.0556
p.S288T	SIDM00732	Glioblastoma	GDSC	HKENK	DEG_APCC_KENBOX_2	0.0556
p.S288T	SIDM01727	Chronic Myelogenous Leukemia	GDSC	HKENK	DEG_APCC_KENBOX_2	0.0556
p.S288T	SIDM00015	Esophageal Squamous Cell Carcinoma	GDSC	HKENK	DEG_APCC_KENBOX_2	0.0556
p.H274Q	ACH-002024	Colon/Colorectal Cancer	CCLE	HKENK	DEG_APCC_KENBOX_2	0.647

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q02383	Semenogelin-2	DEG_APCC_KENBOX_2	341:345	HKENK	APC,CDC20,FZR1	0.9967	More...
Q02383	Semenogelin-2	DEG_APCC_KENBOX_2	401:405	HKENK	APC,CDC20,FZR1	0.9991	More...
Q02383	Semenogelin-2	DEG_APCC_KENBOX_2	461:465	HKENK	APC,CDC20,FZR1	0.8339	More...
Q96QE3	ATPase family AAA domain-containing protein 5	DEG_APCC_KENBOX_2	274:278	HKENK	APC,CDC20,FZR1	0.9122	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons