DegronMD - Q02383(SEMG2)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.Q395E	TCGA-39-5037	LUSC	TCGA	HKENK	DEG_APCC_KENBOX_2	401:405	Mutation rewiring degron network	0.1667
p.Q395E	DO27429	LUSC	ICGC	HKENK	DEG_APCC_KENBOX_2	401:405	Mutation rewiring degron network	0.1667
p.G340D	TCGA-AD-6895	COAD	TCGA	HKENK	DEG_APCC_KENBOX_2	341:345	Mutation rewiring degron network	0.3056
p.G340D	TCGA-XK-AAIW	PRAD	TCGA	HKENK	DEG_APCC_KENBOX_2	341:345	Mutation rewiring degron network	0.3056
p.G340D	DO8938	COAD	ICGC	HKENK	DEG_APCC_KENBOX_2	341:345	Mutation rewiring degron network	0.3056
p.G340D	DO51407	PRAD	ICGC	HKENK	DEG_APCC_KENBOX_2	341:345	Mutation rewiring degron network	0.3056
p.I332T	TCGA-AX-A05Z	UCEC	TCGA	HKENK	DEG_APCC_KENBOX_2	341:345	Mutation rewiring degron network	0.0833
p.I332T	DO40884	UCEC	ICGC	HKENK	DEG_APCC_KENBOX_2	341:345	Mutation rewiring degron network	0.0833
p.S411L	TCGA-B5-A0JY	UCEC	TCGA	HKENK	DEG_APCC_KENBOX_2	401:405	Mutation blocking phosphorylation signal	0.6111
p.S411L	DO48234	ESCA	ICGC	HKENK	DEG_APCC_KENBOX_2	401:405	Mutation blocking phosphorylation signal	0.6111
p.S411L	DO229467	SKCA	ICGC	HKENK	DEG_APCC_KENBOX_2	401:405	Mutation blocking phosphorylation signal	0.6111
p.S411L	DO67028	THCA	ICGC	HKENK	DEG_APCC_KENBOX_2	401:405	Mutation blocking phosphorylation signal	0.6111
p.S411L	DO43041	UCEC	ICGC	HKENK	DEG_APCC_KENBOX_2	401:405	Mutation blocking phosphorylation signal	0.6111
p.E463K	TCGA-CV-7568	HNSC	TCGA	HKENK	DEG_APCC_KENBOX_2	461:465	Mutation altering degron motif	0.7022
p.E463K	TCGA-EE-A2GP	SKCM	TCGA	HKENK	DEG_APCC_KENBOX_2	461:465	Mutation altering degron motif	0.7022
p.E463K	TCGA-EE-A2M6	SKCM	TCGA	HKENK	DEG_APCC_KENBOX_2	461:465	Mutation altering degron motif	0.7022
p.E463K	TCGA-RP-A694	SKCM	TCGA	HKENK	DEG_APCC_KENBOX_2	461:465	Mutation altering degron motif	0.7022
p.E463K	DO14160	HNSC	ICGC	HKENK	DEG_APCC_KENBOX_2	461:465	Mutation altering degron motif	0.7022
p.E463K	DO222514	MELA	ICGC	HKENK	DEG_APCC_KENBOX_2	461:465	Mutation altering degron motif	0.7022
p.E463K	DO229470	SKCA	ICGC	HKENK	DEG_APCC_KENBOX_2	461:465	Mutation altering degron motif	0.7022
p.E463K	DO37422	SKCM	ICGC	HKENK	DEG_APCC_KENBOX_2	461:465	Mutation altering degron motif	0.7022
p.E463K	DO37976	SKCM	ICGC	HKENK	DEG_APCC_KENBOX_2	461:465	Mutation altering degron motif	0.7022
p.E463K	DO51269	SKCM	ICGC	HKENK	DEG_APCC_KENBOX_2	461:465	Mutation altering degron motif	0.7022
p.Q409K	TCGA-D3-A2J6	SKCM	TCGA	HKENK	DEG_APCC_KENBOX_2	401:405	Mutation rewiring degron network	0.2222
p.Q409K	TCGA-EE-A3AA	SKCM	TCGA	HKENK	DEG_APCC_KENBOX_2	401:405	Mutation rewiring degron network	0.2222
p.Q409K	DO37571	SKCM	ICGC	HKENK	DEG_APCC_KENBOX_2	401:405	Mutation rewiring degron network	0.2222
p.Q409K	DO37901	SKCM	ICGC	HKENK	DEG_APCC_KENBOX_2	401:405	Mutation rewiring degron network	0.2222
p.E474K	TCGA-D3-A3C8	SKCM	TCGA	HKENK	DEG_APCC_KENBOX_2	461:465	Mutation rewiring degron network	0.0833
p.E474K	DO47636	SKCM	ICGC	HKENK	DEG_APCC_KENBOX_2	461:465	Mutation rewiring degron network	0.0833
p.H333Y	TCGA-D3-A8GI	SKCM	TCGA	HKENK	DEG_APCC_KENBOX_2	341:345	Mutation rewiring degron network	0.1111
p.H333Y	TCGA-W3-A828	SKCM	TCGA	HKENK	DEG_APCC_KENBOX_2	341:345	Mutation rewiring degron network	0.1111
p.H333Y	DO50284	SKCM	ICGC	HKENK	DEG_APCC_KENBOX_2	341:345	Mutation rewiring degron network	0.1111
p.H333Y	DO51273	SKCM	ICGC	HKENK	DEG_APCC_KENBOX_2	341:345	Mutation rewiring degron network	0.1111
p.P393S	TCGA-D3-A8GJ	SKCM	TCGA	HKENK	DEG_APCC_KENBOX_2	401:405	Mutation rewiring degron network	0.1111
p.P393S	TCGA-D3-A8GM	SKCM	TCGA	HKENK	DEG_APCC_KENBOX_2	401:405	Mutation rewiring degron network	0.1111
p.P393S	TCGA-EB-A551	SKCM	TCGA	HKENK	DEG_APCC_KENBOX_2	401:405	Mutation rewiring degron network	0.1111
p.P393S	TCGA-W3-A825	SKCM	TCGA	HKENK	DEG_APCC_KENBOX_2	401:405	Mutation rewiring degron network	0.1111
p.P393S	DO220877	MELA	ICGC	HKENK	DEG_APCC_KENBOX_2	401:405	Mutation rewiring degron network	0.1111
p.P393S	DO229459	SKCA	ICGC	HKENK	DEG_APCC_KENBOX_2	401:405	Mutation rewiring degron network	0.1111
p.P393S	DO50285	SKCM	ICGC	HKENK	DEG_APCC_KENBOX_2	401:405	Mutation rewiring degron network	0.1111
p.P393S	DO50288	SKCM	ICGC	HKENK	DEG_APCC_KENBOX_2	401:405	Mutation rewiring degron network	0.1111
p.P393S	DO47453	SKCM	ICGC	HKENK	DEG_APCC_KENBOX_2	401:405	Mutation rewiring degron network	0.1111
p.P393S	DO51272	SKCM	ICGC	HKENK	DEG_APCC_KENBOX_2	401:405	Mutation rewiring degron network	0.1111
p.I406M	TCGA-D7-8572	STAD	TCGA	HKENK	DEG_APCC_KENBOX_2	401:405	Mutation rewiring degron network	0.3056
p.I406M	DO47735	STAD	ICGC	HKENK	DEG_APCC_KENBOX_2	401:405	Mutation rewiring degron network	0.3056
p.K345T	TCGA-D9-A1JW	SKCM	TCGA	HKENK	DEG_APCC_KENBOX_2	341:345	Mutation altering degron motif	0.6195
p.K345T	DO37786	SKCM	ICGC	HKENK	DEG_APCC_KENBOX_2	341:345	Mutation altering degron motif	0.6195
p.E463V	TCGA-DD-AADI	LIHC	TCGA	HKENK	DEG_APCC_KENBOX_2	461:465	Mutation altering degron motif	0.7693
p.E463V	DO52233	LIHC	ICGC	HKENK	DEG_APCC_KENBOX_2	461:465	Mutation altering degron motif	0.7693
p.Q469R	TCGA-DI-A1BU	UCEC	TCGA	HKENK	DEG_APCC_KENBOX_2	461:465	Mutation rewiring degron network	0.2222
p.Q469R	DO42023	UCEC	ICGC	HKENK	DEG_APCC_KENBOX_2	461:465	Mutation rewiring degron network	0.2222
p.E403K	TCGA-EB-A3Y7	SKCM	TCGA	HKENK	DEG_APCC_KENBOX_2	401:405	Mutation altering degron motif	0.7022
p.E403K	TCGA-EE-A3AH	SKCM	TCGA	HKENK	DEG_APCC_KENBOX_2	401:405	Mutation altering degron motif	0.7022
p.E403K	DO222635	MELA	ICGC	HKENK	DEG_APCC_KENBOX_2	401:405	Mutation altering degron motif	0.7022
p.E403K	DO37499	SKCM	ICGC	HKENK	DEG_APCC_KENBOX_2	401:405	Mutation altering degron motif	0.7022
p.E403K	DO37443	SKCM	ICGC	HKENK	DEG_APCC_KENBOX_2	401:405	Mutation altering degron motif	0.7022
p.E403K	SIDM01104	Melanoma	GDSC	HKENK	DEG_APCC_KENBOX_2	401:405	Mutation altering degron motif	0.7022
p.E403K	ACH-000640	Skin Cancer	CCLE	HKENK	DEG_APCC_KENBOX_2	401:405	Mutation altering degron motif	0.7022
p.E403K	SK-MEL-31	skin	COSMIC	HKENK	DEG_APCC_KENBOX_2	401:405	Mutation altering degron motif	0.7022
p.E343K	TCGA-EE-A29E	SKCM	TCGA	HKENK	DEG_APCC_KENBOX_2	341:345	Mutation altering degron motif	0.7022
p.E343K	DO222875	MELA	ICGC	HKENK	DEG_APCC_KENBOX_2	341:345	Mutation altering degron motif	0.7022
p.E343K	DO37831	SKCM	ICGC	HKENK	DEG_APCC_KENBOX_2	341:345	Mutation altering degron motif	0.7022
p.Q469K	TCGA-EE-A2GN	SKCM	TCGA	HKENK	DEG_APCC_KENBOX_2	461:465	Mutation rewiring degron network	0.2222
p.Q469K	DO37896	SKCM	ICGC	HKENK	DEG_APCC_KENBOX_2	461:465	Mutation rewiring degron network	0.2222
p.E475K	TCGA-EE-A2GU	SKCM	TCGA	HKENK	DEG_APCC_KENBOX_2	461:465	Mutation rewiring degron network	0.0556
p.E475K	DO37639	SKCM	ICGC	HKENK	DEG_APCC_KENBOX_2	461:465	Mutation rewiring degron network	0.0556
p.T331A	TCGA-EE-A3JB	SKCM	TCGA	HKENK	DEG_APCC_KENBOX_2	341:345	Mutation rewiring degron network	0.0556
p.T331A	DO51250	SKCM	ICGC	HKENK	DEG_APCC_KENBOX_2	341:345	Mutation rewiring degron network	0.0556
p.H459Y	TCGA-F4-6570	COAD	TCGA	HKENK	DEG_APCC_KENBOX_2	461:465	Mutation rewiring degron network	0.2778
p.H459Y	DO10443	COAD	ICGC	HKENK	DEG_APCC_KENBOX_2	461:465	Mutation rewiring degron network	0.2778
p.Q457E	TCGA-FD-A43N	BLCA	TCGA	HKENK	DEG_APCC_KENBOX_2	461:465	Mutation rewiring degron network	0.2222
p.Q457E	DO502	BLCA	ICGC	HKENK	DEG_APCC_KENBOX_2	461:465	Mutation rewiring degron network	0.2222
p.I346M	DO52640	BOCA	ICGC	HKENK	DEG_APCC_KENBOX_2	341:345	Mutation rewiring degron network	0.3056
p.I346M	DO229324	BTCA	ICGC	HKENK	DEG_APCC_KENBOX_2	341:345	Mutation rewiring degron network	0.3056
p.T413A	DO228246	BRCA	ICGC	HKENK	DEG_APCC_KENBOX_2	401:405	Mutation blocking phosphorylation signal	0.5556
p.P453H	DO234275	ESAD	ICGC	HKENK	DEG_APCC_KENBOX_2	461:465	Mutation rewiring degron network	0.1111
p.P453H	DO234185	ESAD	ICGC	HKENK	DEG_APCC_KENBOX_2	461:465	Mutation rewiring degron network	0.1111
p.P453H	DO234198	ESAD	ICGC	HKENK	DEG_APCC_KENBOX_2	461:465	Mutation rewiring degron network	0.1111
p.P453H	DO229352	LAML	ICGC	HKENK	DEG_APCC_KENBOX_2	461:465	Mutation rewiring degron network	0.1111
p.P453H	DO224546	LUSC	ICGC	HKENK	DEG_APCC_KENBOX_2	461:465	Mutation rewiring degron network	0.1111
p.P453H	DO224563	LUSC	ICGC	HKENK	DEG_APCC_KENBOX_2	461:465	Mutation rewiring degron network	0.1111
p.P453H	H513	pleura	COSMIC	HKENK	DEG_APCC_KENBOX_2	461:465	Mutation rewiring degron network	0.1111
p.P453A	DO46478	OV	ICGC	HKENK	DEG_APCC_KENBOX_2	461:465	Mutation rewiring degron network	0.1111
p.P453S	DO218840	SKCA	ICGC	HKENK	DEG_APCC_KENBOX_2	461:465	Mutation rewiring degron network	0.1111
p.E414V	SIDM00955	Melanoma	GDSC	HKENK	DEG_APCC_KENBOX_2	401:405	Mutation rewiring degron network	0.0833
p.E414V	ACH-000812	Skin Cancer	CCLE	HKENK	DEG_APCC_KENBOX_2	401:405	Mutation rewiring degron network	0.0833
p.E414V	COLO-783	skin	COSMIC	HKENK	DEG_APCC_KENBOX_2	401:405	Mutation rewiring degron network	0.0833
p.S471P	SIDM00754	Non-Small Cell Lung Carcinoma	GDSC	HKENK	DEG_APCC_KENBOX_2	461:465	Mutation rewiring degron network	0.1667
p.S471P	ACH-000379	Lung Cancer	CCLE	HKENK	DEG_APCC_KENBOX_2	461:465	Mutation rewiring degron network	0.1667
p.S471P	NCI-H1781	lung	COSMIC	HKENK	DEG_APCC_KENBOX_2	461:465	Mutation rewiring degron network	0.1667
p.R391K	SIDM00767	Small Cell Lung Carcinoma	GDSC	HKENK	DEG_APCC_KENBOX_2	401:405	Mutation rewiring degron network	0.0556
p.R391K	ACH-001136	Lung Cancer	CCLE	HKENK	DEG_APCC_KENBOX_2	401:405	Mutation rewiring degron network	0.0556
p.R391K	NCI-H187	lung	COSMIC	HKENK	DEG_APCC_KENBOX_2	401:405	Mutation rewiring degron network	0.0556
p.S470F	SIDM00118	Colorectal Carcinoma	GDSC	HKENK	DEG_APCC_KENBOX_2	461:465	Mutation rewiring degron network	0.1944
p.S470F	ACH-001081	Colon/Colorectal Cancer	CCLE	HKENK	DEG_APCC_KENBOX_2	461:465	Mutation rewiring degron network	0.1944
p.S470F	HCC2998	large intestine	COSMIC	HKENK	DEG_APCC_KENBOX_2	461:465	Mutation rewiring degron network	0.1944
p.Y408C	SIDM00901	Endometrial Carcinoma	GDSC	HKENK	DEG_APCC_KENBOX_2	401:405	Mutation blocking phosphorylation signal	0.6944
p.Y408C	ACH-000940	Endometrial/Uterine Cancer	CCLE	HKENK	DEG_APCC_KENBOX_2	401:405	Mutation blocking phosphorylation signal	0.6944
p.Y408C	AN3-CA	endometrium	COSMIC	HKENK	DEG_APCC_KENBOX_2	401:405	Mutation blocking phosphorylation signal	0.6944
p.M466V	SIDM01608	Endometrial Carcinoma	GDSC	HKENK	DEG_APCC_KENBOX_2	461:465	Mutation rewiring degron network	0.3056
p.M466V	ACH-000990	Endometrial/Uterine Cancer	CCLE	HKENK	DEG_APCC_KENBOX_2	461:465	Mutation rewiring degron network	0.3056
p.H339Y	ACH-000894	Lung Cancer	CCLE	HKENK	DEG_APCC_KENBOX_2	341:345	Mutation rewiring degron network	0.2778

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SEMG2

UniProt ID: Q02383

Entrez ID: 6407

Protein name: Semenogelin-2 (Semenogelin II) (SGII)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SEMG2 in