DegronMD

Uniprot ID: Q02383

Source protein: Semenogelin-2

Source gene: SEMG2

Class: DEG_APCC_KENBOX_2

Location: 461:465

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8339

ASA_SCORE: 134.66

COIL: 0.7774

CONS_SCORE: 0.4243

DSS_SCORE: 0.7661

HELIX: 0.2054

FCONS_SCORE: 1

RIG_SCORE: 0.6258

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E463K	TCGA-CV-7568	HNSC	TCGA	HKENK	DEG_APCC_KENBOX_2	0.7022
p.E463K	TCGA-EE-A2GP	SKCM	TCGA	HKENK	DEG_APCC_KENBOX_2	0.7022
p.E463K	TCGA-EE-A2M6	SKCM	TCGA	HKENK	DEG_APCC_KENBOX_2	0.7022
p.E463K	TCGA-RP-A694	SKCM	TCGA	HKENK	DEG_APCC_KENBOX_2	0.7022
p.E463K	DO14160	HNSC	ICGC	HKENK	DEG_APCC_KENBOX_2	0.7022
p.E463K	DO222514	MELA	ICGC	HKENK	DEG_APCC_KENBOX_2	0.7022
p.E463K	DO229470	SKCA	ICGC	HKENK	DEG_APCC_KENBOX_2	0.7022
p.E463K	DO37422	SKCM	ICGC	HKENK	DEG_APCC_KENBOX_2	0.7022
p.E463K	DO37976	SKCM	ICGC	HKENK	DEG_APCC_KENBOX_2	0.7022
p.E463K	DO51269	SKCM	ICGC	HKENK	DEG_APCC_KENBOX_2	0.7022
p.E474K	TCGA-D3-A3C8	SKCM	TCGA	HKENK	DEG_APCC_KENBOX_2	0.0833
p.E474K	DO47636	SKCM	ICGC	HKENK	DEG_APCC_KENBOX_2	0.0833
p.E463V	TCGA-DD-AADI	LIHC	TCGA	HKENK	DEG_APCC_KENBOX_2	0.7693
p.E463V	DO52233	LIHC	ICGC	HKENK	DEG_APCC_KENBOX_2	0.7693
p.Q469R	TCGA-DI-A1BU	UCEC	TCGA	HKENK	DEG_APCC_KENBOX_2	0.2222
p.Q469R	DO42023	UCEC	ICGC	HKENK	DEG_APCC_KENBOX_2	0.2222
p.Q469K	TCGA-EE-A2GN	SKCM	TCGA	HKENK	DEG_APCC_KENBOX_2	0.2222
p.Q469K	DO37896	SKCM	ICGC	HKENK	DEG_APCC_KENBOX_2	0.2222
p.E475K	TCGA-EE-A2GU	SKCM	TCGA	HKENK	DEG_APCC_KENBOX_2	0.0556
p.E475K	DO37639	SKCM	ICGC	HKENK	DEG_APCC_KENBOX_2	0.0556
p.H459Y	TCGA-F4-6570	COAD	TCGA	HKENK	DEG_APCC_KENBOX_2	0.2778
p.H459Y	DO10443	COAD	ICGC	HKENK	DEG_APCC_KENBOX_2	0.2778
p.Q457E	TCGA-FD-A43N	BLCA	TCGA	HKENK	DEG_APCC_KENBOX_2	0.2222
p.Q457E	DO502	BLCA	ICGC	HKENK	DEG_APCC_KENBOX_2	0.2222
p.P453H	DO234275	ESAD	ICGC	HKENK	DEG_APCC_KENBOX_2	0.1111
p.P453H	DO234185	ESAD	ICGC	HKENK	DEG_APCC_KENBOX_2	0.1111
p.P453H	DO234198	ESAD	ICGC	HKENK	DEG_APCC_KENBOX_2	0.1111
p.P453H	DO229352	LAML	ICGC	HKENK	DEG_APCC_KENBOX_2	0.1111
p.P453H	DO224546	LUSC	ICGC	HKENK	DEG_APCC_KENBOX_2	0.1111
p.P453H	DO224563	LUSC	ICGC	HKENK	DEG_APCC_KENBOX_2	0.1111
p.P453H	H513	pleura	COSMIC	HKENK	DEG_APCC_KENBOX_2	0.1111
p.P453A	DO46478	OV	ICGC	HKENK	DEG_APCC_KENBOX_2	0.1111
p.P453S	DO218840	SKCA	ICGC	HKENK	DEG_APCC_KENBOX_2	0.1111
p.S471P	SIDM00754	Non-Small Cell Lung Carcinoma	GDSC	HKENK	DEG_APCC_KENBOX_2	0.1667
p.S471P	ACH-000379	Lung Cancer	CCLE	HKENK	DEG_APCC_KENBOX_2	0.1667
p.S471P	NCI-H1781	lung	COSMIC	HKENK	DEG_APCC_KENBOX_2	0.1667
p.S470F	SIDM00118	Colorectal Carcinoma	GDSC	HKENK	DEG_APCC_KENBOX_2	0.1944
p.S470F	ACH-001081	Colon/Colorectal Cancer	CCLE	HKENK	DEG_APCC_KENBOX_2	0.1944
p.S470F	HCC2998	large_intestine	COSMIC	HKENK	DEG_APCC_KENBOX_2	0.1944
p.M466V	SIDM01608	Endometrial Carcinoma	GDSC	HKENK	DEG_APCC_KENBOX_2	0.3056
p.M466V	ACH-000990	Endometrial/Uterine Cancer	CCLE	HKENK	DEG_APCC_KENBOX_2	0.3056

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: HKENK

Degron related mutations and impact score

Drug responses associated with SEMG2 mutations

All proteins holding degron of HKENK

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q02383	Semenogelin-2	DEG_APCC_KENBOX_2	341:345	HKENK	APC,CDC20,FZR1	0.9967	More...
Q02383	Semenogelin-2	DEG_APCC_KENBOX_2	401:405	HKENK	APC,CDC20,FZR1	0.9991	More...
Q02383	Semenogelin-2	DEG_APCC_KENBOX_2	461:465	HKENK	APC,CDC20,FZR1	0.8339	More...
Q96QE3	ATPase family AAA domain-containing protein 5	DEG_APCC_KENBOX_2	274:278	HKENK	APC,CDC20,FZR1	0.9122	More...