DegronMD

Uniprot ID: Q02383

Source protein: Semenogelin-2

Source gene: SEMG2

Class: DEG_APCC_KENBOX_2

Location: 341:345

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9967

ASA_SCORE: 138.34

COIL: 0.7874

CONS_SCORE: 0.9781

DSS_SCORE: 0.7095

HELIX: 0.1982

FCONS_SCORE: 1.0304

RIG_SCORE: 0.647

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G340D	TCGA-AD-6895	COAD	TCGA	HKENK	DEG_APCC_KENBOX_2	0.3056
p.G340D	TCGA-XK-AAIW	PRAD	TCGA	HKENK	DEG_APCC_KENBOX_2	0.3056
p.G340D	DO8938	COAD	ICGC	HKENK	DEG_APCC_KENBOX_2	0.3056
p.G340D	DO51407	PRAD	ICGC	HKENK	DEG_APCC_KENBOX_2	0.3056
p.I332T	TCGA-AX-A05Z	UCEC	TCGA	HKENK	DEG_APCC_KENBOX_2	0.0833
p.I332T	DO40884	UCEC	ICGC	HKENK	DEG_APCC_KENBOX_2	0.0833
p.H333Y	TCGA-D3-A8GI	SKCM	TCGA	HKENK	DEG_APCC_KENBOX_2	0.1111
p.H333Y	TCGA-W3-A828	SKCM	TCGA	HKENK	DEG_APCC_KENBOX_2	0.1111
p.H333Y	DO50284	SKCM	ICGC	HKENK	DEG_APCC_KENBOX_2	0.1111
p.H333Y	DO51273	SKCM	ICGC	HKENK	DEG_APCC_KENBOX_2	0.1111
p.K345T	TCGA-D9-A1JW	SKCM	TCGA	HKENK	DEG_APCC_KENBOX_2	0.6195
p.K345T	DO37786	SKCM	ICGC	HKENK	DEG_APCC_KENBOX_2	0.6195
p.E343K	TCGA-EE-A29E	SKCM	TCGA	HKENK	DEG_APCC_KENBOX_2	0.7022
p.E343K	DO222875	MELA	ICGC	HKENK	DEG_APCC_KENBOX_2	0.7022
p.E343K	DO37831	SKCM	ICGC	HKENK	DEG_APCC_KENBOX_2	0.7022
p.T331A	TCGA-EE-A3JB	SKCM	TCGA	HKENK	DEG_APCC_KENBOX_2	0.0556
p.T331A	DO51250	SKCM	ICGC	HKENK	DEG_APCC_KENBOX_2	0.0556
p.I346M	DO52640	BOCA	ICGC	HKENK	DEG_APCC_KENBOX_2	0.3056
p.I346M	DO229324	BTCA	ICGC	HKENK	DEG_APCC_KENBOX_2	0.3056
p.H339Y	ACH-000894	Lung Cancer	CCLE	HKENK	DEG_APCC_KENBOX_2	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q02383	Semenogelin-2	DEG_APCC_KENBOX_2	341:345	HKENK	APC,CDC20,FZR1	0.9967	More...
Q02383	Semenogelin-2	DEG_APCC_KENBOX_2	401:405	HKENK	APC,CDC20,FZR1	0.9991	More...
Q02383	Semenogelin-2	DEG_APCC_KENBOX_2	461:465	HKENK	APC,CDC20,FZR1	0.8339	More...
Q96QE3	ATPase family AAA domain-containing protein 5	DEG_APCC_KENBOX_2	274:278	HKENK	APC,CDC20,FZR1	0.9122	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons