DegronMD

Uniprot ID: Q02383

Source protein: Semenogelin-2

Source gene: SEMG2

Class: DEG_APCC_KENBOX_2

Location: 401:405

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9991

ASA_SCORE: 130.46

COIL: 0.8038

CONS_SCORE: 0.9043

DSS_SCORE: 0.6389

HELIX: 0.1748

FCONS_SCORE: 1.3501

RIG_SCORE: 0.6724

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q395E	TCGA-39-5037	LUSC	TCGA	HKENK	DEG_APCC_KENBOX_2	0.1667
p.Q395E	DO27429	LUSC	ICGC	HKENK	DEG_APCC_KENBOX_2	0.1667
p.S411L	TCGA-B5-A0JY	UCEC	TCGA	HKENK	DEG_APCC_KENBOX_2	0.6111
p.S411L	DO48234	ESCA	ICGC	HKENK	DEG_APCC_KENBOX_2	0.6111
p.S411L	DO229467	SKCA	ICGC	HKENK	DEG_APCC_KENBOX_2	0.6111
p.S411L	DO67028	THCA	ICGC	HKENK	DEG_APCC_KENBOX_2	0.6111
p.S411L	DO43041	UCEC	ICGC	HKENK	DEG_APCC_KENBOX_2	0.6111
p.Q409K	TCGA-D3-A2J6	SKCM	TCGA	HKENK	DEG_APCC_KENBOX_2	0.2222
p.Q409K	TCGA-EE-A3AA	SKCM	TCGA	HKENK	DEG_APCC_KENBOX_2	0.2222
p.Q409K	DO37571	SKCM	ICGC	HKENK	DEG_APCC_KENBOX_2	0.2222
p.Q409K	DO37901	SKCM	ICGC	HKENK	DEG_APCC_KENBOX_2	0.2222
p.P393S	TCGA-D3-A8GJ	SKCM	TCGA	HKENK	DEG_APCC_KENBOX_2	0.1111
p.P393S	TCGA-D3-A8GM	SKCM	TCGA	HKENK	DEG_APCC_KENBOX_2	0.1111
p.P393S	TCGA-EB-A551	SKCM	TCGA	HKENK	DEG_APCC_KENBOX_2	0.1111
p.P393S	TCGA-W3-A825	SKCM	TCGA	HKENK	DEG_APCC_KENBOX_2	0.1111
p.P393S	DO220877	MELA	ICGC	HKENK	DEG_APCC_KENBOX_2	0.1111
p.P393S	DO229459	SKCA	ICGC	HKENK	DEG_APCC_KENBOX_2	0.1111
p.P393S	DO50285	SKCM	ICGC	HKENK	DEG_APCC_KENBOX_2	0.1111
p.P393S	DO50288	SKCM	ICGC	HKENK	DEG_APCC_KENBOX_2	0.1111
p.P393S	DO47453	SKCM	ICGC	HKENK	DEG_APCC_KENBOX_2	0.1111
p.P393S	DO51272	SKCM	ICGC	HKENK	DEG_APCC_KENBOX_2	0.1111
p.I406M	TCGA-D7-8572	STAD	TCGA	HKENK	DEG_APCC_KENBOX_2	0.3056
p.I406M	DO47735	STAD	ICGC	HKENK	DEG_APCC_KENBOX_2	0.3056
p.E403K	TCGA-EB-A3Y7	SKCM	TCGA	HKENK	DEG_APCC_KENBOX_2	0.7022
p.E403K	TCGA-EE-A3AH	SKCM	TCGA	HKENK	DEG_APCC_KENBOX_2	0.7022
p.E403K	DO222635	MELA	ICGC	HKENK	DEG_APCC_KENBOX_2	0.7022
p.E403K	DO37499	SKCM	ICGC	HKENK	DEG_APCC_KENBOX_2	0.7022
p.E403K	DO37443	SKCM	ICGC	HKENK	DEG_APCC_KENBOX_2	0.7022
p.E403K	SIDM01104	Melanoma	GDSC	HKENK	DEG_APCC_KENBOX_2	0.7022
p.E403K	ACH-000640	Skin Cancer	CCLE	HKENK	DEG_APCC_KENBOX_2	0.7022
p.E403K	SK-MEL-31	skin	COSMIC	HKENK	DEG_APCC_KENBOX_2	0.7022
p.T413A	DO228246	BRCA	ICGC	HKENK	DEG_APCC_KENBOX_2	0.5556
p.E414V	SIDM00955	Melanoma	GDSC	HKENK	DEG_APCC_KENBOX_2	0.0833
p.E414V	ACH-000812	Skin Cancer	CCLE	HKENK	DEG_APCC_KENBOX_2	0.0833
p.E414V	COLO-783	skin	COSMIC	HKENK	DEG_APCC_KENBOX_2	0.0833
p.R391K	SIDM00767	Small Cell Lung Carcinoma	GDSC	HKENK	DEG_APCC_KENBOX_2	0.0556
p.R391K	ACH-001136	Lung Cancer	CCLE	HKENK	DEG_APCC_KENBOX_2	0.0556
p.R391K	NCI-H187	lung	COSMIC	HKENK	DEG_APCC_KENBOX_2	0.0556
p.Y408C	SIDM00901	Endometrial Carcinoma	GDSC	HKENK	DEG_APCC_KENBOX_2	0.6944
p.Y408C	ACH-000940	Endometrial/Uterine Cancer	CCLE	HKENK	DEG_APCC_KENBOX_2	0.6944
p.Y408C	AN3-CA	endometrium	COSMIC	HKENK	DEG_APCC_KENBOX_2	0.6944

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: HKENK

Degron related mutations and impact score

Drug responses associated with SEMG2 mutations

All proteins holding degron of HKENK

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q02383	Semenogelin-2	DEG_APCC_KENBOX_2	341:345	HKENK	APC,CDC20,FZR1	0.9967	More...
Q02383	Semenogelin-2	DEG_APCC_KENBOX_2	401:405	HKENK	APC,CDC20,FZR1	0.9991	More...
Q02383	Semenogelin-2	DEG_APCC_KENBOX_2	461:465	HKENK	APC,CDC20,FZR1	0.8339	More...
Q96QE3	ATPase family AAA domain-containing protein 5	DEG_APCC_KENBOX_2	274:278	HKENK	APC,CDC20,FZR1	0.9122	More...