DegronMD

Uniprot ID: Q96QE3

Source protein: ATPase family AAA domain-containing protein 5

Source gene: ATAD5

Class: DEG_SCF_FBW7_1

Location: 588:594

E3 ligase: FBXW7

DEGRON score: 0.9974

ASA_SCORE: 101.8571

COIL: 0.9186

CONS_SCORE: 0.3434

DSS_SCORE: 0.5576

HELIX: 0.0521

FCONS_SCORE: 1.2147

RIG_SCORE: 0.6721

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S584I	TCGA-2G-AAM3	TGCT	TCGA	VSTPKST	DEG_SCF_FBW7_1	0.2222
p.K592T	TCGA-AA-3984	COAD	TCGA	VSTPKST	DEG_SCF_FBW7_1	0.6195
p.K592T	DO9002	COAD	ICGC	VSTPKST	DEG_SCF_FBW7_1	0.6195
p.S581Y	TCGA-AX-A1CE	UCEC	TCGA	VSTPKST	DEG_SCF_FBW7_1	0.1389
p.S581Y	DO42280	UCEC	ICGC	VSTPKST	DEG_SCF_FBW7_1	0.1389
p.S581C	TCGA-D3-A2JP	SKCM	TCGA	VSTPKST	DEG_SCF_FBW7_1	0.1389
p.S581C	DO47407	SKCM	ICGC	VSTPKST	DEG_SCF_FBW7_1	0.1389
p.E582K	TCGA-GC-A3I6	BLCA	TCGA	VSTPKST	DEG_SCF_FBW7_1	0.1667
p.E582K	DO844	BLCA	ICGC	VSTPKST	DEG_SCF_FBW7_1	0.1667
p.R596I	DO229028	LICA	ICGC	VSTPKST	DEG_SCF_FBW7_1	0.2778
p.L585F	SIDM00253	Neuroblastoma	GDSC	VSTPKST	DEG_SCF_FBW7_1	0.25
p.L585F	NB6	autonomic_ganglia	COSMIC	VSTPKST	DEG_SCF_FBW7_1	0.25
p.A583V	SIDM00569	Osteosarcoma	GDSC	VSTPKST	DEG_SCF_FBW7_1	0.1944
p.A583V	ACH-002178	Bone Cancer	CCLE	VSTPKST	DEG_SCF_FBW7_1	0.1944
p.A583V	NY	bone	COSMIC	VSTPKST	DEG_SCF_FBW7_1	0.1944
p.R596T	ACH-001673	Bile Duct Cancer	CCLE	VSTPKST	DEG_SCF_FBW7_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96QE3	ATPase family AAA domain-containing protein 5	DEG_SCF_FBW7_1	588:594	VSTPKST	FBXW7	0.9974	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons