DegronMD

Uniprot ID: P42695

Source protein: Condensin-2 complex subunit D3

Source gene: NCAPD3

Class: DEG_SCF_FBW7_1

Location: 1413:1419

E3 ligase: FBXW7

DEGRON score: 0.998

ASA_SCORE: 99.3857

COIL: 0.9129

CONS_SCORE: 0.3091

DSS_SCORE: 0.4419

HELIX: 0.0387

FCONS_SCORE: 1.1341

RIG_SCORE: 0.7214

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E1406D	TCGA-21-1080	LUSC	TCGA	ISTPEKS	DEG_SCF_FBW7_1	0.1389
p.E1406D	DO26502	LUSC	ICGC	ISTPEKS	DEG_SCF_FBW7_1	0.1389
p.S1414G	TCGA-95-7039	LUAD	TCGA	ISTPEKS	DEG_SCF_FBW7_1	0.6993
p.S1414G	DO23907	LUAD	ICGC	ISTPEKS	DEG_SCF_FBW7_1	0.6993
p.E1404K	TCGA-AP-A0LM	UCEC	TCGA	ISTPEKS	DEG_SCF_FBW7_1	0.0833
p.E1404K	DO43306	UCEC	ICGC	ISTPEKS	DEG_SCF_FBW7_1	0.0833
p.E1404K	SIDM00213	Thyroid Gland Carcinoma	GDSC	ISTPEKS	DEG_SCF_FBW7_1	0.0833
p.E1404K	SIDM00228	Thyroid Gland Carcinoma	GDSC	ISTPEKS	DEG_SCF_FBW7_1	0.0833
p.T1424M	TCGA-BR-8361	STAD	TCGA	ISTPEKS	DEG_SCF_FBW7_1	0.6389
p.T1424M	TCGA-SX-A7SL	KIRP	TCGA	ISTPEKS	DEG_SCF_FBW7_1	0.6389
p.T1424M	DO49783	KIRP	ICGC	ISTPEKS	DEG_SCF_FBW7_1	0.6389
p.T1424M	DO48032	STAD	ICGC	ISTPEKS	DEG_SCF_FBW7_1	0.6389
p.E1417K	TCGA-D1-A17Q	UCEC	TCGA	ISTPEKS	DEG_SCF_FBW7_1	0.591
p.E1417K	DO41903	UCEC	ICGC	ISTPEKS	DEG_SCF_FBW7_1	0.591
p.S1419C	TCGA-UF-A71B	HNSC	TCGA	ISTPEKS	DEG_SCF_FBW7_1	0.8652
p.S1419C	DO52107	HNSC	ICGC	ISTPEKS	DEG_SCF_FBW7_1	0.8652
p.V1408M	DO230311	COCA	ICGC	ISTPEKS	DEG_SCF_FBW7_1	0.1944
p.V1408M	SIDM00103	Mesothelioma	GDSC	ISTPEKS	DEG_SCF_FBW7_1	0.1944
p.V1408M	ACH-002124	Lung Cancer	CCLE	ISTPEKS	DEG_SCF_FBW7_1	0.1944
p.V1408M	H2373	pleura	COSMIC	ISTPEKS	DEG_SCF_FBW7_1	0.1944
p.T1409N	DO228952	LICA	ICGC	ISTPEKS	DEG_SCF_FBW7_1	0.2222
p.T1424K	DO229026	LICA	ICGC	ISTPEKS	DEG_SCF_FBW7_1	0.6389
p.P1416T	DO229037	LICA	ICGC	ISTPEKS	DEG_SCF_FBW7_1	0.7031
p.P1416T	DO220886	MELA	ICGC	ISTPEKS	DEG_SCF_FBW7_1	0.7031
p.H1407Q	DO230550	LUSC	ICGC	ISTPEKS	DEG_SCF_FBW7_1	0.1667
p.R1411W	DO229221	THCA	ICGC	ISTPEKS	DEG_SCF_FBW7_1	0.2778
p.G1428A	SIDM00406	B-Cell Non-Hodgkin's Lymphoma	GDSC	ISTPEKS	DEG_SCF_FBW7_1	0.0833
p.G1428A	ACH-000660	Lymphoma	CCLE	ISTPEKS	DEG_SCF_FBW7_1	0.0833
p.G1428A	SU-DHL-5	haematopoietic_and_lymphoid_tissue	COSMIC	ISTPEKS	DEG_SCF_FBW7_1	0.0833

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: ISTPEKS

Degron related mutations and impact score

Drug responses associated with NCAPD3 mutations

All proteins holding degron of ISTPEKS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P42695	Condensin-2 complex subunit D3	DEG_SCF_FBW7_1	1413:1419	ISTPEKS	FBXW7	0.998	More...