DegronMD - P42695(NCAPD3)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E1406D	TCGA-21-1080	LUSC	TCGA	ISTPEKS	DEG_SCF_FBW7_1	1413:1419	Mutation rewiring degron network	0.1389
p.E1406D	DO26502	LUSC	ICGC	ISTPEKS	DEG_SCF_FBW7_1	1413:1419	Mutation rewiring degron network	0.1389
p.R1490P	TCGA-44-A4SU	LUAD	TCGA	LRKTPLKT	DEG_SCF_FBW7_1	1489:1496	Mutation altering degron motif	0.6401
p.R1490P	DO24507	LUAD	ICGC	LRKTPLKT	DEG_SCF_FBW7_1	1489:1496	Mutation altering degron motif	0.6401
p.Q1314H	TCGA-53-7624	LUAD	TCGA	PCTPRAS	DEG_SCF_FBW7_1	1315:1321	Mutation rewiring degron network	0.3056
p.Q1314H	DO25058	LUAD	ICGC	PCTPRAS	DEG_SCF_FBW7_1	1315:1321	Mutation rewiring degron network	0.3056
p.S1414G	TCGA-95-7039	LUAD	TCGA	ISTPEKS	DEG_SCF_FBW7_1	1413:1419	Mutation altering degron motif	0.6993
p.S1414G	DO23907	LUAD	ICGC	ISTPEKS	DEG_SCF_FBW7_1	1413:1419	Mutation altering degron motif	0.6993
p.E1404K	TCGA-AP-A0LM	UCEC	TCGA	ISTPEKS	DEG_SCF_FBW7_1	1413:1419	Mutation rewiring degron network	0.0833
p.E1404K	DO43306	UCEC	ICGC	ISTPEKS	DEG_SCF_FBW7_1	1413:1419	Mutation rewiring degron network	0.0833
p.E1404K	SIDM00213	Thyroid Gland Carcinoma	GDSC	ISTPEKS	DEG_SCF_FBW7_1	1413:1419	Mutation rewiring degron network	0.0833
p.E1404K	SIDM00228	Thyroid Gland Carcinoma	GDSC	ISTPEKS	DEG_SCF_FBW7_1	1413:1419	Mutation rewiring degron network	0.0833
p.R1490Q	TCGA-AX-A06F	UCEC	TCGA	LRKTPLKT	DEG_SCF_FBW7_1	1489:1496	Mutation altering degron motif	0.6218
p.R1490Q	DO41752	UCEC	ICGC	LRKTPLKT	DEG_SCF_FBW7_1	1489:1496	Mutation altering degron motif	0.6218
p.R1490Q	SIDM00210	Ovarian Carcinoma	GDSC	LRKTPLKT	DEG_SCF_FBW7_1	1489:1496	Mutation altering degron motif	0.6218
p.M1308I	TCGA-BG-A18B	UCEC	TCGA	PCTPRAS	DEG_SCF_FBW7_1	1315:1321	Mutation rewiring degron network	0.1389
p.M1308I	DO41452	UCEC	ICGC	PCTPRAS	DEG_SCF_FBW7_1	1315:1321	Mutation rewiring degron network	0.1389
p.P1330H	TCGA-BG-A221	UCEC	TCGA	PCTPRAS	DEG_SCF_FBW7_1	1315:1321	Mutation rewiring degron network	0.0833
p.P1330H	DO42384	UCEC	ICGC	PCTPRAS	DEG_SCF_FBW7_1	1315:1321	Mutation rewiring degron network	0.0833
p.T1424M	TCGA-BR-8361	STAD	TCGA	ISTPEKS	DEG_SCF_FBW7_1	1413:1419	Mutation blocking phosphorylation signal	0.6389
p.T1424M	TCGA-SX-A7SL	KIRP	TCGA	ISTPEKS	DEG_SCF_FBW7_1	1413:1419	Mutation blocking phosphorylation signal	0.6389
p.T1424M	DO49783	KIRP	ICGC	ISTPEKS	DEG_SCF_FBW7_1	1413:1419	Mutation blocking phosphorylation signal	0.6389
p.T1424M	DO48032	STAD	ICGC	ISTPEKS	DEG_SCF_FBW7_1	1413:1419	Mutation blocking phosphorylation signal	0.6389
p.E1417K	TCGA-D1-A17Q	UCEC	TCGA	ISTPEKS	DEG_SCF_FBW7_1	1413:1419	Mutation altering degron motif	0.591
p.E1417K	DO41903	UCEC	ICGC	ISTPEKS	DEG_SCF_FBW7_1	1413:1419	Mutation altering degron motif	0.591
p.K1491T	TCGA-QG-A5Z2	COAD	TCGA	LRKTPLKT	DEG_SCF_FBW7_1	1489:1496	Mutation altering degron motif	0.6195
p.K1491T	DO44096	COAD	ICGC	LRKTPLKT	DEG_SCF_FBW7_1	1489:1496	Mutation altering degron motif	0.6195
p.S1419C	TCGA-UF-A71B	HNSC	TCGA	ISTPEKS	DEG_SCF_FBW7_1	1413:1419	Mutation altering degron motif	0.8652
p.S1419C	DO52107	HNSC	ICGC	ISTPEKS	DEG_SCF_FBW7_1	1413:1419	Mutation altering degron motif	0.8652
p.G1323V	TCGA-WQ-AB4B	LIHC	TCGA	PCTPRAS	DEG_SCF_FBW7_1	1315:1321	Mutation rewiring degron network	0.2778
p.G1323V	DO52327	LIHC	ICGC	PCTPRAS	DEG_SCF_FBW7_1	1315:1321	Mutation rewiring degron network	0.2778
p.V1408M	DO230311	COCA	ICGC	ISTPEKS	DEG_SCF_FBW7_1	1413:1419	Mutation rewiring degron network	0.1944
p.V1408M	SIDM00103	Mesothelioma	GDSC	ISTPEKS	DEG_SCF_FBW7_1	1413:1419	Mutation rewiring degron network	0.1944
p.V1408M	ACH-002124	Lung Cancer	CCLE	ISTPEKS	DEG_SCF_FBW7_1	1413:1419	Mutation rewiring degron network	0.1944
p.V1408M	H2373	pleura	COSMIC	ISTPEKS	DEG_SCF_FBW7_1	1413:1419	Mutation rewiring degron network	0.1944
p.T1409N	DO228952	LICA	ICGC	ISTPEKS	DEG_SCF_FBW7_1	1413:1419	Mutation rewiring degron network	0.2222
p.P1318H	DO229027	LICA	ICGC	PCTPRAS	DEG_SCF_FBW7_1	1315:1321	Mutation altering degron motif	0.7694
p.T1424K	DO229026	LICA	ICGC	ISTPEKS	DEG_SCF_FBW7_1	1413:1419	Mutation blocking phosphorylation signal	0.6389
p.P1416T	DO229037	LICA	ICGC	ISTPEKS	DEG_SCF_FBW7_1	1413:1419	Mutation altering degron motif	0.7031
p.P1416T	DO220886	MELA	ICGC	ISTPEKS	DEG_SCF_FBW7_1	1413:1419	Mutation altering degron motif	0.7031
p.H1407Q	DO230550	LUSC	ICGC	ISTPEKS	DEG_SCF_FBW7_1	1413:1419	Mutation rewiring degron network	0.1667
p.N1305T	DO229453	SKCA	ICGC	PCTPRAS	DEG_SCF_FBW7_1	1315:1321	Mutation rewiring degron network	0.0556
p.N1305T	DO218878	SKCA	ICGC	PCTPRAS	DEG_SCF_FBW7_1	1315:1321	Mutation rewiring degron network	0.0556
p.L1494P	DO229259	THCA	ICGC	LRKTPLKT	DEG_SCF_FBW7_1	1489:1496	Mutation altering degron motif	0.6471
p.R1411W	DO229221	THCA	ICGC	ISTPEKS	DEG_SCF_FBW7_1	1413:1419	Mutation rewiring degron network	0.2778
p.G1428A	SIDM00406	B-Cell Non-Hodgkin's Lymphoma	GDSC	ISTPEKS	DEG_SCF_FBW7_1	1413:1419	Mutation rewiring degron network	0.0833
p.G1428A	ACH-000660	Lymphoma	CCLE	ISTPEKS	DEG_SCF_FBW7_1	1413:1419	Mutation rewiring degron network	0.0833
p.G1428A	SU-DHL-5	haematopoietic and lymphoid tissue	COSMIC	ISTPEKS	DEG_SCF_FBW7_1	1413:1419	Mutation rewiring degron network	0.0833
p.K1479Q	SIDM00698	Small Cell Lung Carcinoma	GDSC	LRKTPLKT	DEG_SCF_FBW7_1	1489:1496	Mutation substituting flanking lysine	0.1667
p.K1479Q	ACH-000506	Lung Cancer	CCLE	LRKTPLKT	DEG_SCF_FBW7_1	1489:1496	Mutation substituting flanking lysine	0.1667
p.K1479Q	NCI-H146	lung	COSMIC	LRKTPLKT	DEG_SCF_FBW7_1	1489:1496	Mutation substituting flanking lysine	0.1667
p.K1491E	SIDM00122	Breast Carcinoma	GDSC	LRKTPLKT	DEG_SCF_FBW7_1	1489:1496	Mutation altering degron motif	0.591
p.K1491E	ACH-000288	Breast Cancer	CCLE	LRKTPLKT	DEG_SCF_FBW7_1	1489:1496	Mutation altering degron motif	0.591
p.K1491E	BT-549	breast	COSMIC	LRKTPLKT	DEG_SCF_FBW7_1	1489:1496	Mutation altering degron motif	0.591
p.V1312M	SIDM00628	Breast Carcinoma	GDSC	PCTPRAS	DEG_SCF_FBW7_1	1315:1321	Mutation rewiring degron network	0.25
p.V1312M	SIDM01387	Small Cell Lung Carcinoma	GDSC	PCTPRAS	DEG_SCF_FBW7_1	1315:1321	Mutation rewiring degron network	0.25

DegronMD: protein-targeted degradation, mutation and drug response to degrons

NCAPD3

UniProt ID: P42695

Entrez ID: 23310

Protein name: Condensin-2 complex subunit D3 (Non-SMC condensin II complex subunit D3) (hCAP-D3)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for NCAPD3 in