DegronMD

Uniprot ID: P42695

Source protein: Condensin-2 complex subunit D3

Source gene: NCAPD3

Class: DEG_SCF_FBW7_1

Location: 1489:1496

E3 ligase: FBXW7

DEGRON score: 0.9507

ASA_SCORE: 127.6

COIL: 0.9598

CONS_SCORE: 0.2332

DSS_SCORE: 0.8611

HELIX: 0.0241

FCONS_SCORE: 0.9027

RIG_SCORE: 0.6975

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R1490P	TCGA-44-A4SU	LUAD	TCGA	LRKTPLKT	DEG_SCF_FBW7_1	0.6401
p.R1490P	DO24507	LUAD	ICGC	LRKTPLKT	DEG_SCF_FBW7_1	0.6401
p.R1490Q	TCGA-AX-A06F	UCEC	TCGA	LRKTPLKT	DEG_SCF_FBW7_1	0.6218
p.R1490Q	DO41752	UCEC	ICGC	LRKTPLKT	DEG_SCF_FBW7_1	0.6218
p.R1490Q	SIDM00210	Ovarian Carcinoma	GDSC	LRKTPLKT	DEG_SCF_FBW7_1	0.6218
p.K1491T	TCGA-QG-A5Z2	COAD	TCGA	LRKTPLKT	DEG_SCF_FBW7_1	0.6195
p.K1491T	DO44096	COAD	ICGC	LRKTPLKT	DEG_SCF_FBW7_1	0.6195
p.L1494P	DO229259	THCA	ICGC	LRKTPLKT	DEG_SCF_FBW7_1	0.6471
p.K1479Q	SIDM00698	Small Cell Lung Carcinoma	GDSC	LRKTPLKT	DEG_SCF_FBW7_1	0.1667
p.K1479Q	ACH-000506	Lung Cancer	CCLE	LRKTPLKT	DEG_SCF_FBW7_1	0.1667
p.K1479Q	NCI-H146	lung	COSMIC	LRKTPLKT	DEG_SCF_FBW7_1	0.1667
p.K1491E	SIDM00122	Breast Carcinoma	GDSC	LRKTPLKT	DEG_SCF_FBW7_1	0.591
p.K1491E	ACH-000288	Breast Cancer	CCLE	LRKTPLKT	DEG_SCF_FBW7_1	0.591
p.K1491E	BT-549	breast	COSMIC	LRKTPLKT	DEG_SCF_FBW7_1	0.591

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P42695	Condensin-2 complex subunit D3	DEG_SCF_FBW7_1	1489:1496	LRKTPLKT	FBXW7	0.9507	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons