DegronMD

Uniprot ID: P42695

Source protein: Condensin-2 complex subunit D3

Source gene: NCAPD3

Class: DEG_SCF_FBW7_1

Location: 1315:1321

E3 ligase: FBXW7

DEGRON score: 0.9978

ASA_SCORE: 86.4857

COIL: 0.919

CONS_SCORE: 0.2683

DSS_SCORE: 0.4991

HELIX: 0.0561

FCONS_SCORE: 1.0727

RIG_SCORE: 0.6203

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q1314H	TCGA-53-7624	LUAD	TCGA	PCTPRAS	DEG_SCF_FBW7_1	0.3056
p.Q1314H	DO25058	LUAD	ICGC	PCTPRAS	DEG_SCF_FBW7_1	0.3056
p.M1308I	TCGA-BG-A18B	UCEC	TCGA	PCTPRAS	DEG_SCF_FBW7_1	0.1389
p.M1308I	DO41452	UCEC	ICGC	PCTPRAS	DEG_SCF_FBW7_1	0.1389
p.P1330H	TCGA-BG-A221	UCEC	TCGA	PCTPRAS	DEG_SCF_FBW7_1	0.0833
p.P1330H	DO42384	UCEC	ICGC	PCTPRAS	DEG_SCF_FBW7_1	0.0833
p.G1323V	TCGA-WQ-AB4B	LIHC	TCGA	PCTPRAS	DEG_SCF_FBW7_1	0.2778
p.G1323V	DO52327	LIHC	ICGC	PCTPRAS	DEG_SCF_FBW7_1	0.2778
p.P1318H	DO229027	LICA	ICGC	PCTPRAS	DEG_SCF_FBW7_1	0.7694
p.N1305T	DO229453	SKCA	ICGC	PCTPRAS	DEG_SCF_FBW7_1	0.0556
p.N1305T	DO218878	SKCA	ICGC	PCTPRAS	DEG_SCF_FBW7_1	0.0556
p.V1312M	SIDM00628	Breast Carcinoma	GDSC	PCTPRAS	DEG_SCF_FBW7_1	0.25
p.V1312M	SIDM01387	Small Cell Lung Carcinoma	GDSC	PCTPRAS	DEG_SCF_FBW7_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P42695	Condensin-2 complex subunit D3	DEG_SCF_FBW7_1	1315:1321	PCTPRAS	FBXW7	0.9978	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons