DegronMD

Uniprot ID: Q8WXI7

Source protein: Mucin-16

Source gene: MUC16

Class: DEG_SCF_FBW7_1

Location: 8773:8779

E3 ligase: FBXW7

DEGRON score: 0.893

ASA_SCORE: 90.3571

COIL: 0.8861

CONS_SCORE: 0

DSS_SCORE: 0.6152

HELIX: 0.0147

FCONS_SCORE: 0

RIG_SCORE: 0.7455

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E8784K	TCGA-06-5416	GBM	TCGA	ISTPLTT	DEG_SCF_FBW7_1	0.1944
p.E8784K	DO10880	GBM	ICGC	ISTPLTT	DEG_SCF_FBW7_1	0.1944
p.E8784K	DO220882	MELA	ICGC	ISTPLTT	DEG_SCF_FBW7_1	0.1944
p.I8770V	TCGA-44-6774	LUAD	TCGA	ISTPLTT	DEG_SCF_FBW7_1	0.25
p.I8770V	DO25000	LUAD	ICGC	ISTPLTT	DEG_SCF_FBW7_1	0.25
p.T8767S	TCGA-49-AARQ	LUAD	TCGA	ISTPLTT	DEG_SCF_FBW7_1	0.1667
p.T8767S	DO51189	LUAD	ICGC	ISTPLTT	DEG_SCF_FBW7_1	0.1667
p.T8779M	TCGA-55-8207	LUAD	TCGA	ISTPLTT	DEG_SCF_FBW7_1	0.8534
p.T8779M	DO233251	GACA	ICGC	ISTPLTT	DEG_SCF_FBW7_1	0.8534
p.T8779M	DO45351	LUAD	ICGC	ISTPLTT	DEG_SCF_FBW7_1	0.8534
p.I8765M	TCGA-56-8201	LUSC	TCGA	ISTPLTT	DEG_SCF_FBW7_1	0.1111
p.I8765M	DO223724	LUSC	ICGC	ISTPLTT	DEG_SCF_FBW7_1	0.1111
p.E8764K	TCGA-AX-A2HC	UCEC	TCGA	ISTPLTT	DEG_SCF_FBW7_1	0.0833
p.E8764K	TCGA-CA-6718	COAD	TCGA	ISTPLTT	DEG_SCF_FBW7_1	0.0833
p.E8764K	DO7801	COAD	ICGC	ISTPLTT	DEG_SCF_FBW7_1	0.0833
p.E8764K	DO41572	UCEC	ICGC	ISTPLTT	DEG_SCF_FBW7_1	0.0833
p.S8766F	TCGA-D3-A5GO	SKCM	TCGA	ISTPLTT	DEG_SCF_FBW7_1	0.1389
p.S8766F	TCGA-YD-A89C	SKCM	TCGA	ISTPLTT	DEG_SCF_FBW7_1	0.1389
p.S8766F	DO220909	MELA	ICGC	ISTPLTT	DEG_SCF_FBW7_1	0.1389
p.S8766F	DO229494	SKCA	ICGC	ISTPLTT	DEG_SCF_FBW7_1	0.1389
p.S8766F	DO47419	SKCM	ICGC	ISTPLTT	DEG_SCF_FBW7_1	0.1389
p.S8766F	DO219501	SKCM	ICGC	ISTPLTT	DEG_SCF_FBW7_1	0.1389
p.G8781R	TCGA-EE-A29M	SKCM	TCGA	ISTPLTT	DEG_SCF_FBW7_1	0.2778
p.G8781R	DO37404	SKCM	ICGC	ISTPLTT	DEG_SCF_FBW7_1	0.2778
p.G8781R	SIDM00755	Non-Small Cell Lung Carcinoma	GDSC	ISTPLTT	DEG_SCF_FBW7_1	0.2778
p.G8781R	ACH-000888	Lung Cancer	CCLE	ISTPLTT	DEG_SCF_FBW7_1	0.2778
p.G8781R	NCI-H1793	lung	COSMIC	ISTPLTT	DEG_SCF_FBW7_1	0.2778
p.S8774Y	TCGA-EO-A3B0	UCEC	TCGA	ISTPLTT	DEG_SCF_FBW7_1	0.6009
p.S8774Y	DO219773	UCEC	ICGC	ISTPLTT	DEG_SCF_FBW7_1	0.6009
p.R8772I	TCGA-F5-6814	READ	TCGA	ISTPLTT	DEG_SCF_FBW7_1	0.3056
p.R8772I	DO36556	READ	ICGC	ISTPLTT	DEG_SCF_FBW7_1	0.3056
p.P8789S	TCGA-FR-A7U9	SKCM	TCGA	ISTPLTT	DEG_SCF_FBW7_1	0.0556
p.P8789S	DO48546	SKCM	ICGC	ISTPLTT	DEG_SCF_FBW7_1	0.0556
p.I8773V	TCGA-IB-7651	PAAD	TCGA	ISTPLTT	DEG_SCF_FBW7_1	0.5965
p.I8773V	DO46657	PAAD	ICGC	ISTPLTT	DEG_SCF_FBW7_1	0.5965
p.P8776L	TCGA-OD-A75X	SKCM	TCGA	ISTPLTT	DEG_SCF_FBW7_1	0.7582
p.P8776L	TCGA-QC-A7B5	SARC	TCGA	ISTPLTT	DEG_SCF_FBW7_1	0.7582
p.P8776L	DO220239	SARC	ICGC	ISTPLTT	DEG_SCF_FBW7_1	0.7582
p.P8776L	DO48601	SKCM	ICGC	ISTPLTT	DEG_SCF_FBW7_1	0.7582
p.P8789R	DO227999	COCA	ICGC	ISTPLTT	DEG_SCF_FBW7_1	0.0556
p.P8789R	DO229003	COCA	ICGC	ISTPLTT	DEG_SCF_FBW7_1	0.0556
p.P8789R	DO230659	LAML	ICGC	ISTPLTT	DEG_SCF_FBW7_1	0.0556
p.P8789R	DO231140	LAML	ICGC	ISTPLTT	DEG_SCF_FBW7_1	0.0556
p.P8789R	DO230529	LUSC	ICGC	ISTPLTT	DEG_SCF_FBW7_1	0.0556
p.P8789R	SIDM01034	B-Lymphoblastic Leukemia	GDSC	ISTPLTT	DEG_SCF_FBW7_1	0.0556
p.P8789R	SIDM00570	Gastric Carcinoma	GDSC	ISTPLTT	DEG_SCF_FBW7_1	0.0556
p.P8789R	SIDM00215	Colorectal Carcinoma	GDSC	ISTPLTT	DEG_SCF_FBW7_1	0.0556
p.P8789R	SIDM00557	Neuroblastoma	GDSC	ISTPLTT	DEG_SCF_FBW7_1	0.0556
p.P8789R	SIDM00322	Esophageal Squamous Cell Carcinoma	GDSC	ISTPLTT	DEG_SCF_FBW7_1	0.0556
p.P8789R	SIDM00434	Plasma Cell Myeloma	GDSC	ISTPLTT	DEG_SCF_FBW7_1	0.0556
p.P8789R	SIDM00437	Acute Myeloid Leukemia	GDSC	ISTPLTT	DEG_SCF_FBW7_1	0.0556
p.P8789R	SIDM00578	Neuroblastoma	GDSC	ISTPLTT	DEG_SCF_FBW7_1	0.0556
p.P8789R	SIDM00617	Hepatocellular Carcinoma	GDSC	ISTPLTT	DEG_SCF_FBW7_1	0.0556
p.P8789R	SIDM00075	Non-Cancerous	GDSC	ISTPLTT	DEG_SCF_FBW7_1	0.0556
p.P8789R	SIDM00614	Hepatocellular Carcinoma	GDSC	ISTPLTT	DEG_SCF_FBW7_1	0.0556
p.P8789R	SIDM00495	B-Cell Non-Hodgkin's Lymphoma	GDSC	ISTPLTT	DEG_SCF_FBW7_1	0.0556
p.P8789R	SIDM00513	Non-Small Cell Lung Carcinoma	GDSC	ISTPLTT	DEG_SCF_FBW7_1	0.0556
p.P8789R	SIDM00352	Ovarian Carcinoma	GDSC	ISTPLTT	DEG_SCF_FBW7_1	0.0556
p.P8789R	SIDM00584	Osteosarcoma	GDSC	ISTPLTT	DEG_SCF_FBW7_1	0.0556
p.P8789R	SIDM01199	Hepatocellular Carcinoma	GDSC	ISTPLTT	DEG_SCF_FBW7_1	0.0556
p.P8789R	SIDM01219	Non-Small Cell Lung Carcinoma	GDSC	ISTPLTT	DEG_SCF_FBW7_1	0.0556
p.P8789R	SIDM00291	Melanoma	GDSC	ISTPLTT	DEG_SCF_FBW7_1	0.0556
p.P8789R	SIDM00315	Glioblastoma	GDSC	ISTPLTT	DEG_SCF_FBW7_1	0.0556
p.P8789R	SIDM01005	Acute Myeloid Leukemia	GDSC	ISTPLTT	DEG_SCF_FBW7_1	0.0556
p.P8789R	SIDM00569	Osteosarcoma	GDSC	ISTPLTT	DEG_SCF_FBW7_1	0.0556
p.P8789R	SIDM00193	Colorectal Carcinoma	GDSC	ISTPLTT	DEG_SCF_FBW7_1	0.0556
p.P8789R	SIDM01028	Esophageal Squamous Cell Carcinoma	GDSC	ISTPLTT	DEG_SCF_FBW7_1	0.0556
p.P8789R	SIDM00267	Biliary Tract Carcinoma	GDSC	ISTPLTT	DEG_SCF_FBW7_1	0.0556
p.P8789R	SIDM00590	Oral Cavity Carcinoma	GDSC	ISTPLTT	DEG_SCF_FBW7_1	0.0556
p.P8789R	SIDM00465	Ovarian Carcinoma	GDSC	ISTPLTT	DEG_SCF_FBW7_1	0.0556
p.P8789R	SIDM00581	Glioblastoma	GDSC	ISTPLTT	DEG_SCF_FBW7_1	0.0556
p.P8789R	SIDM00293	Small Cell Lung Carcinoma	GDSC	ISTPLTT	DEG_SCF_FBW7_1	0.0556
p.P8789R	SIDM00457	Plasma Cell Myeloma	GDSC	ISTPLTT	DEG_SCF_FBW7_1	0.0556
p.P8789R	SIDM00060	Ovarian Carcinoma	GDSC	ISTPLTT	DEG_SCF_FBW7_1	0.0556
p.P8789R	SIDM00364	B-Lymphoblastic Leukemia	GDSC	ISTPLTT	DEG_SCF_FBW7_1	0.0556
p.P8789R	SIDM00568	Gastric Carcinoma	GDSC	ISTPLTT	DEG_SCF_FBW7_1	0.0556
p.P8789R	SIDM01026	Esophageal Squamous Cell Carcinoma	GDSC	ISTPLTT	DEG_SCF_FBW7_1	0.0556
p.P8789R	SIDM00556	Neuroblastoma	GDSC	ISTPLTT	DEG_SCF_FBW7_1	0.0556
p.P8789R	SIDM00235	Kidney Carcinoma	GDSC	ISTPLTT	DEG_SCF_FBW7_1	0.0556
p.P8789R	SIDM00278	Esophageal Squamous Cell Carcinoma	GDSC	ISTPLTT	DEG_SCF_FBW7_1	0.0556
p.P8789R	SIDM00487	Colorectal Carcinoma	GDSC	ISTPLTT	DEG_SCF_FBW7_1	0.0556
p.P8789R	SIDM00294	Small Cell Lung Carcinoma	GDSC	ISTPLTT	DEG_SCF_FBW7_1	0.0556
p.P8789R	SIDM00564	Ovarian Carcinoma	GDSC	ISTPLTT	DEG_SCF_FBW7_1	0.0556
p.P8789R	SIDM00498	Colorectal Carcinoma	GDSC	ISTPLTT	DEG_SCF_FBW7_1	0.0556
p.P8789R	SIDM01024	Esophageal Squamous Cell Carcinoma	GDSC	ISTPLTT	DEG_SCF_FBW7_1	0.0556
p.P8789R	SIDM00567	Other Solid Cancers	GDSC	ISTPLTT	DEG_SCF_FBW7_1	0.0556
p.P8789R	SIDM00240	Cervical Carcinoma	GDSC	ISTPLTT	DEG_SCF_FBW7_1	0.0556
p.P8789R	SIDM00612	Glioma	GDSC	ISTPLTT	DEG_SCF_FBW7_1	0.0556
p.P8789R	SIDM00357	Small Cell Lung Carcinoma	GDSC	ISTPLTT	DEG_SCF_FBW7_1	0.0556
p.P8789R	SIDM01019	Acute Myeloid Leukemia	GDSC	ISTPLTT	DEG_SCF_FBW7_1	0.0556
p.P8789R	SIDM00325	Esophageal Squamous Cell Carcinoma	GDSC	ISTPLTT	DEG_SCF_FBW7_1	0.0556
p.P8789R	SIDM00347	Esophageal Squamous Cell Carcinoma	GDSC	ISTPLTT	DEG_SCF_FBW7_1	0.0556
p.P8789R	SIDM00245	Small Cell Lung Carcinoma	GDSC	ISTPLTT	DEG_SCF_FBW7_1	0.0556
p.P8789R	SIDM00283	B-Cell Non-Hodgkin's Lymphoma	GDSC	ISTPLTT	DEG_SCF_FBW7_1	0.0556
p.P8789R	SIDM00280	Gastric Carcinoma	GDSC	ISTPLTT	DEG_SCF_FBW7_1	0.0556
p.P8789R	SIDM00549	B-Lymphoblastic Leukemia	GDSC	ISTPLTT	DEG_SCF_FBW7_1	0.0556
p.P8789R	SIDM00271	Gastric Carcinoma	GDSC	ISTPLTT	DEG_SCF_FBW7_1	0.0556
p.P8789R	SIDM00469	Pancreatic Carcinoma	GDSC	ISTPLTT	DEG_SCF_FBW7_1	0.0556
p.P8789R	SIDM00560	Gastric Carcinoma	GDSC	ISTPLTT	DEG_SCF_FBW7_1	0.0556
p.P8789R	SIDM00326	Esophageal Squamous Cell Carcinoma	GDSC	ISTPLTT	DEG_SCF_FBW7_1	0.0556
p.P8789R	SIDM00380	Acute Myeloid Leukemia	GDSC	ISTPLTT	DEG_SCF_FBW7_1	0.0556
p.P8789R	SIDM01025	Esophageal Squamous Cell Carcinoma	GDSC	ISTPLTT	DEG_SCF_FBW7_1	0.0556
p.P8789R	SIDM00233	T-Lymphoblastic Leukemia	GDSC	ISTPLTT	DEG_SCF_FBW7_1	0.0556
p.P8789R	SIDM00302	Other Solid Cancers	GDSC	ISTPLTT	DEG_SCF_FBW7_1	0.0556
p.P8789R	SIDM01018	Hodgkin's Lymphoma	GDSC	ISTPLTT	DEG_SCF_FBW7_1	0.0556
p.P8789R	SIDM00412	B-Cell Non-Hodgkin's Lymphoma	GDSC	ISTPLTT	DEG_SCF_FBW7_1	0.0556
p.P8789R	SIDM00026	Other Solid Cancers	GDSC	ISTPLTT	DEG_SCF_FBW7_1	0.0556
p.P8789R	SIDM01728	Endometrial Carcinoma	GDSC	ISTPLTT	DEG_SCF_FBW7_1	0.0556
p.P8789R	SIDM01609	Endometrial Carcinoma	GDSC	ISTPLTT	DEG_SCF_FBW7_1	0.0556
p.P8789R	SIDM01608	Endometrial Carcinoma	GDSC	ISTPLTT	DEG_SCF_FBW7_1	0.0556
p.P8789R	SIDM01659	Kidney Carcinoma	GDSC	ISTPLTT	DEG_SCF_FBW7_1	0.0556
p.P8789R	SIDM01617	Endometrial Carcinoma	GDSC	ISTPLTT	DEG_SCF_FBW7_1	0.0556
p.P8789R	SIDM00168	Head and Neck Carcinoma	GDSC	ISTPLTT	DEG_SCF_FBW7_1	0.0556
p.P8789R	SIDM01412	Oral Cavity Carcinoma	GDSC	ISTPLTT	DEG_SCF_FBW7_1	0.0556
p.P8789R	SIDM00169	Head and Neck Carcinoma	GDSC	ISTPLTT	DEG_SCF_FBW7_1	0.0556
p.P8789R	SIDM01770	Gastric Carcinoma	GDSC	ISTPLTT	DEG_SCF_FBW7_1	0.0556
p.P8789R	SIDM01622	Breast Carcinoma	GDSC	ISTPLTT	DEG_SCF_FBW7_1	0.0556
p.P8789R	SIDM01377	Ovarian Carcinoma	GDSC	ISTPLTT	DEG_SCF_FBW7_1	0.0556
p.P8789R	SIDM01336	Glioblastoma	GDSC	ISTPLTT	DEG_SCF_FBW7_1	0.0556
p.P8789R	SIDM01432	Kidney Carcinoma	GDSC	ISTPLTT	DEG_SCF_FBW7_1	0.0556
p.P8789R	SIDM00784	Glioma	GDSC	ISTPLTT	DEG_SCF_FBW7_1	0.0556
p.P8789R	SIDM01575	Plasma Cell Myeloma	GDSC	ISTPLTT	DEG_SCF_FBW7_1	0.0556
p.P8789R	SIDM01658	Unknown	GDSC	ISTPLTT	DEG_SCF_FBW7_1	0.0556
p.P8789R	SIDM00500	Colorectal Carcinoma	GDSC	ISTPLTT	DEG_SCF_FBW7_1	0.0556
p.P8789R	SIDM00171	Colorectal Carcinoma	GDSC	ISTPLTT	DEG_SCF_FBW7_1	0.0556
p.P8789R	SIDM01774	Pancreatic Carcinoma	GDSC	ISTPLTT	DEG_SCF_FBW7_1	0.0556
p.P8789R	SIDM00016	Neuroblastoma	GDSC	ISTPLTT	DEG_SCF_FBW7_1	0.0556
p.P8789R	SIDM01434	Hepatocellular Carcinoma	GDSC	ISTPLTT	DEG_SCF_FBW7_1	0.0556
p.P8789R	SIDM01729	Endometrial Carcinoma	GDSC	ISTPLTT	DEG_SCF_FBW7_1	0.0556
p.P8789R	SIDM01619	Endometrial Carcinoma	GDSC	ISTPLTT	DEG_SCF_FBW7_1	0.0556
p.P8789R	SIDM01443	Gastric Carcinoma	GDSC	ISTPLTT	DEG_SCF_FBW7_1	0.0556
p.T8767M	DO52485	COCA	ICGC	ISTPLTT	DEG_SCF_FBW7_1	0.1667
p.T8767M	DO234336	ESAD	ICGC	ISTPLTT	DEG_SCF_FBW7_1	0.1667
p.T8767M	DO233210	GACA	ICGC	ISTPLTT	DEG_SCF_FBW7_1	0.1667
p.S8782A	DO233765	GACA	ICGC	ISTPLTT	DEG_SCF_FBW7_1	0.6944
p.T8779K	DO229029	LICA	ICGC	ISTPLTT	DEG_SCF_FBW7_1	0.8417
p.A8783E	DO229038	LICA	ICGC	ISTPLTT	DEG_SCF_FBW7_1	0.2222
p.M8785I	DO220878	MELA	ICGC	ISTPLTT	DEG_SCF_FBW7_1	0.1667
p.E8768K	DO222653	MELA	ICGC	ISTPLTT	DEG_SCF_FBW7_1	0.1944
p.G8781E	DO222731	MELA	ICGC	ISTPLTT	DEG_SCF_FBW7_1	0.2778

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: ISTPLTT

Degron related mutations and impact score

Drug responses associated with MUC16 mutations

All proteins holding degron of ISTPLTT

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8WXI7	Mucin-16	DEG_SCF_FBW7_1	8773:8779	ISTPLTT	FBXW7	0.893	More...